Guardians vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks, Sept. 21

Let’s check the latest MLB picks, stats, injury reports, and MLB odds for Guardians vs White Sox. We’ve plenty of MLB predictions for you to consider.

Guardians at the Gate

It’s not often that a 3-3 game after nine innings ends 10-7, but such was the case in Tuesday night’s opener of this three-game Chitown series.

It was Cleveland Guardians scoring twice in the top of the 10th, matched by the White Sox. It was Cleveland scoring five times in the top of the 11th, which was three more than the White Sox.

Seven Kwan went 4-of-6 to lead the offense.

The sportsbooks see the desperation in Chicago made Cleveland a tepid underdog Wednesday.

Righthander Triston McKenzie (10-11, 3.08 ERA) makes his 28th start/29th appearance of the season. McKenzie hasn’t taken a loss in his last three, having not allowed more than three runs once in his last eight.

Chisox Burning Daylight

Chicago White Sox pitcher Vince Velasquez said, “We’re taking the right steps to do some damage against Cleveland at home.”

That was before Tuesday.

Chicago will have veteran righty Lance Lynn on the mound Wednesday, 7-5 with a 3.99 ERA. Lynn’s last game was an 8-2 victory over the Guardians last week.

Guardians vs White Sox Head-to-Head

Cleveland is leading, 10-7, clinching the season series between the teams. Keep this in mind when betting online.

Guardians vs White Sox Game Information

• Game: Guardians (81-67) vs White Sox (76-72)
• Location: Guaranteed Rate Field, Chicago, IL
• Day/Time: Wednesday, Sept, 21st, 8:10 p.m. ET
• Guardians vs White Sox Live stream: MLB.tv

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Guardians vs White Sox Betting Lines

Guardians vs White Sox Prediction

Chicago cannot afford to lose this game, so perhaps that motivation is sufficient.

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