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Guardians vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks, Sept. 22

Red-Hot Cleveland Bidding for Sweep

Guardians in Control of AL Central

The Cleveland Guardians go for a fourth straight win when they take on the host Chicago White Sox in the finale of a three-game series on Thursday night. Cleveland has won the first two games of the series to open their lead in the American League Central standings over the second-place White Sox to six games.

Chicago has lost two in a row and is 5½ games behind the Seattle Mariners for the final Wild Card spot in the American League. These division rivals are very familiar with each other, so this should be another hard-fought contest. To help with your betting online, check out our in-depth preview of the series finale.

Guardians vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks, Sept. 22
Guardians vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks, Sept. 22

Let’s check the latest MLB picks, stats, injury reports, and MLB odds for Guardians vs White Sox. We’ve plenty of MLB predictions for you to consider.

Guardians Lighting Up Scoreboard

The Cleveland Guardians have become one of the more prolific teams at the plate, scoring 29 runs over their current three-game winning streak. Cleveland put up eight runs on Wednesday night, led by rookie outfielder Steven Kwan, who had three hits, including a home run.

We got guys hitting home runs, doubles, big RBIs,” Kwan said after Wednesday’s win. “Luckily I’m hitting well now.”

Kwan was 3-for-5 with two runs scored and has gone 14-for-26 over his last five games. Kwan is batting .298, adding 22 doubles, six triples, five home runs, 43 RBIs and 80 runs scored.

Second baseman Andrew Gimenez was 2-for-4 with two RBIs and a run scored on Wednesday. He’s batting .299 with 25 doubles, three triples, 16 home runs, 65 RBIs and 62 runs scored.

Right-hander Shane Bieber will get the start for the series finale. Bieber is 11-8 with a 2.83 ERA in 28 starts, striking out 184 in 181⅓ innings. He has been hot in September, going 3-1 with a 1.84 ERA in four starts, striking out 31 and walking three over 29⅓ innings.

White Sox Fading

With just a couple of weeks left of the 2022 regular season, a playoff berth is still within the reach of the Chicago White Sox, but they need to get hot and make up some ground in a hurry. Chicago doesn’t have an easy schedule the rest of the way and needs to get as many wins as possible.

Trying to get things started on Thursday will be veteran right-hander Johnny Cueto. The 36-year-old is 7-8 with a 3.09 ERA in 21 starts and 22 overall appearances, striking out 88 in 139⅔ innings. He’s coming off an ugly outing against the Oakland Athletics on Sunday, lasting just 4⅔ innings and allowing seven runs (five earned) on eight hits while striking out three and walking one.

Third baseman Yoan Moncada had a solo home run in Wednesday’s loss. Moncada is batting .215 with 14 doubles, a triple, 11 home runs, 48 RBIs and 38 runs scored in 93 games.

Guardians vs White Sox Head-To-Head

The Cleveland Guardians have already clinched the season series, leading the Chicago White Sox 11-7 heading into the final matchup. Cleveland is 5-3 at Guaranteed Rate Field this season.

The White Sox took the season series 10-9 last season, though the teams split 10 contests played in Chicago. The MLB lines for the series finale are giving the edge to the visitors, as the Guardians are favored to earn another victory.

Guardians vs White Sox Game Information

  • Game: Guardians (82-67) vs White Sox (76-73)
  • Location: Guaranteed Rate Field, Chicago
  • Day/Time: Thursday, Sept. 22, 8:10 p.m. ET
  • Guardians vs White Sox Live stream:  MLB.tv

Guardians vs White Sox Betting Lines

Team Run Line Moneyline Total Team Total
Cleveland Guardians
S. Bieber -R
-1½ +125 -140 7 -120o 3½ -135o
3½ +105u
Chicago White Sox
J. Cueto -R
+1½ -145 +125 7 Evu 3½ +120o
3½ -150u

Guardians vs White Sox Prediction

The Cleveland Guardians are playing extremely well as they drive toward a division title, and that’s going to continue on Thursday. The Chicago White Sox just don’t have enough offense to compete right now and the Guardians will finish the series sweep with a victory.

When making your MLB picks, take Cleveland to win on the road.

Guardians vs White Sox Edge

Guardians vs White Sox Results

Guardians vs White Sox Game Injuries

Guardians vs White Sox Game Summary

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