Mariners vs Athletics Prediction, Game Preview, Live Stream, Odds & Picks Sept. 20
Mariners Bring Playoff Drive to Oakland
Seattle’s ‘Last’ in Wild-Card Race
The Seattle Mariners travel to oppose the Oakland Athletics in the first of a three-game Bay Area series Tuesday night. Seattle snapped a three-game losing skid with a win over the Los Angeles Angels Monday, and now leads the Baltimore Orioles by five games eyeing the final AL wild-card spot. Oakland’s lost three-of-four, in last place in the AL West. Check out our in-depth preview of Tuesday’s game to help you decide how you want to make your bet online.
Let’s check the latest MLB picks, stats, injury reports, and MLB odds for Mariners vs Athletics. We’ve plenty of MLB predictions for you to consider.

Mariners End Skid With Monday Win
The Seattle Mariners had their troubles with the sad sack Los Angeles Angels, having dropped the first three games of their four-game series. Monday was a different story, with Seattle dominant in a 9-1 victory behind the hot bat of Carlos Santana’s two homers.
“My wife told me, ‘Like, I think if you don’t get a home run you don’t love your mom.’ I said, ‘OK, I love my mom,'” Santana said after Monday’s win, which came on his mother’s birthday. “That’s a lot of love right there.”
Santana also drove in five runs in the contest, and has seven home runs in the last nine games. The 36-year-old is batting just .186 since coming to the Mariners in a mid-season trade (Kansas City), but has six doubles, 15 homers, 36 RBIs and 29 runs scored in 64 games with Seattle.
Righthander Luis Castillo gets the start for Tuesday’s contest, his eighth with Seattle since coming to the team in a deadline deal (Cincinnati). Castillo is 3-1 with a 2.37 ERA with the Mariners, striking out 60 in 49⅓ innings. He’s coming off a win over the San Diego Padres last Wednesday (six scoreless innings, four hits, nine strikeouts, one walk).
Athletics Can’t Score
The Oakland Athletics have had one of the worst scoring teams in baseball this season, and that continued against the Houston Astros. Oakland managed just four runs in losing three-of- four, and were shut out Friday.
First baseman Dermis Garcia drove in the only two Oakland runs in Sunday’s loss with a double. Garcia is batting .254 with five doubles, four home runs, 17 RBIs and nine runs scored in 25 games in his rookie season
Lefthander JP Sears gets the start for the series opener. Sears is 5-2 with a 3.90 ERA in nine (14 appearances) with Oakland and the New York Yankees this season, striking out 36 in 55⅓ innings. Sears struggled in his last two, going a total of six innings while surrendering 11 earned runs on 15 hits, including three home runs.
Mariners vs Athletics Head-To-Head
The Seattle Mariners have gone 8-5 against the Oakland Athletics this season. Seattle is going for their second straight season series win after taking 15-of-19 games in 2021.
Playing at Oakland Coliseum has not been a problem, either. Seattle is 12-3 at the venue since the beginning of the 2021 campaign. A look at the MLB lines for Tuesday’s series expects that success to continue, with the Mariners favored to come away with the victory.
Mariners vs Athletics Game Information
- Game: Mariners (81-65) vs Athletics (53-94)
- Location: Oakland Coliseum, Oakland, CA
- Day/Time: Tuesday, 9:40 p.m. ET
- Mariners vs Athletics Live stream: MLB.tv
Mariners vs Athletics Betting Lines
Team |
Run Line
|
Moneyline | Total | Team Total |
Seattle Mariners
L. Castillo -R |
-1½ -120 | -210 | 7Evo | 4½+115o
4½-145u |
Oakland Athletics
J. Sears -L |
+1½ Ev | +180 | 7-120u | 2½-110o
2½-120u |
Mariners vs Athletics Prediction
The Seattle Mariners are getting into playoff mode, drawing an Oakland Athletics team with little offense and a struggling pitcher. The Mariners should cruise in this one.
When making your MLB picks, take Seattle to win on the road.