Marlins vs Cardinals Predictions, Game Preview, Live Stream, Odds & Picks, June 29
St. Louis Bidding for Sweep of Series
Cardinals Battling for NL Central Lead
The St. Louis Cardinals are on the verge of sweeping the Miami Marlins at Busch Stadium, which would help them tremendously as they are fighting neck and neck with the Milwaukee Brewers for first place in the National League Central.
The Marlins will put up a fight, sending Sandy Alcantara to the mound in Wednesday’s series finale. The Cardinals will need to stay hot and scratch across every run they can to give themselves a chance.

Check the latest MLB picks, stats, injury reports and MLB odds for Marlins vs Cardinals. There are plenty of MLB predictions.
Marlins Trying to Avoid Sweep
On Wednesday night, the Miami Marlins will be looking to avoid being swept by the Cardinals in St. Louis. The Marlins are in fourth place in the National League East. Although they are not completely out of the race, they would need to start getting back on track quickly.
Their offense has started to produce, but the quality of pitching that carried them early in the season has faded. If the Marlins can reclaim some of the magic and get more performances like the ones Alcantara is turning out, they could easily start to crawl out of the hole they have dug for themselves.
The Marlins have surrendered 14 runs over the first two games of the series. With his 1.95 ERA, Alcantara has the capability of keeping the Cardinals off the scoreboard. Can the Marlins shift the momentum away from the Cardinals?
Cardinals Want Sweep
The St. Louis Cardinals are a half-game behind the Brewers in their NL Central race.
The Cardinals should be able to keep pace with the Brewers, who have been streaky all season long.
In this series with the Marlins, the bats have been performing well, as has the pitching staff. St. Louis has outscored the Marlins 14-3 over two games and will look to continue that in the series finale.
But the offense will have their toughest matchup of the series as they face the Miami’s top pitcher. Alcantara is a front-runner for the Cy Young Award. He’ll be opposed by the young Andre Pallante, who has really pitched better than his 2-3 record might indicate.
The rookie pitcher is sporting a 2.03 ERA and has made four starts with 22 appearances overall. He is not a strong strikeout pitcher, but the Cardinals are known for their great defense to back Pallante’s ground ball tendencies.
Marlins vs Cardinals Head-to-Head
Wednesday’s game will wrap up the season series between the Marlins and the Cardinals. The Cardinals have a dominant grip on the series with a 4-1 lead.
The winning team has also covered the runline in every game in this season series in 2022.
Marlins vs Cardinals Game Information
- Game: Marlins (33-40) vs Cardinals (43-34)
- Location: Busch Stadium, St. Louis, MO
- Day/Time: Wednesday, 7:45 p.m. ET
- Marlins vs Cardinals Live Stream: MLB.TV
Marlins vs Cardinals Betting Lines
Team | Handicap | Moneyline | Total | Team Total |
Miami Marlins
S. Alcantara -R |
-1½ +145 | -118 | 7½ -125o | 3½ -135o
3½ +105u |
St. Louis Cardinals
A. Pallante -R |
+1½ -165 | +108 | 7½ +105u | 3½ -105o
3½ -125u |
Marlins vs Cardinals Prediction
The sportsbooks have the Marlins as -118 favorites in this matchup, mostly due to the pitching matchup, which puts Alcantara against Cardinals rookie Pallante.
But the rookie has pitched well all season long, and the Cardinals have one of the better offenses in the MLB. Taking the Cardinals at +108 might be a worthwhile bet on the underdog.
The MLB lines show the Marlins’ odds of covering the runline at +145. This could be good, but the Marlins have struggled to cover the runline, and the Cardinals are playing better baseball.
When you bet online, take the moneyline win by the Cardinals at +108.