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MLB Spread Picks: Take Dodgers Over Cardinals ATS

The 2024 MLB season begins in full force on Thursday, though the Los Angeles Dodgers will be playing their third game of the campaign when they host the St. Louis Cardinals for the opener of a four-game weekend series at Dodger Stadium. Los Angeles split a two-game series with the San Diego Padres in Seoul, South Korea, last week.

The Dodgers have been in the news a lot since signing free agent Shohei Ohtani, cementing their spot among the MLB betting favorites to win the World Series. Meanwhile, the Cardinals are coming off a very disappointing 2023 campaign and are hoping to start the road back to the postseason with a win in Los Angeles. St. Louis will have Miles Mikolas (9-13, 4.78 ERA in 2023) on the mound for its season opener while Tyler Glasnow (0-0, 3.60 ERA) gets the start for Los Angeles

MLB Spread Picks: Take Dodgers Over Cardinals ATS
MLB Spread Picks: Take Dodgers Over Cardinals ATS


Cardinals vs Dodgers Game Information

  • Game: Cardinals (0-0) vs Dodgers (1-1)
  • Date/Time: Thursday, March 28, 4:10 p.m. ET
  • Location: Dodger Stadium, Los Angeles, Calif.
  • Cardinals vs Dodgers Live Stream: MLB.tv


These two teams played seven games in 2023, with the Dodgers coming out on top in four of those, including a three-game sweep of a home series in April. The MLB odds for this game favor the host team at -230 on the moneyline while St. Louis is listed at +190. If you’re betting on the run line of 1½, you can get the favored Dodgers at -125 while the Cardinals are at +105. The over/under has been set at 8½ runs.


Cardinals vs Dodgers Odds and Spreads


  • St. Louis is 0-4 in its last four Thursday games.
  • Los Angeles is 1-4 in its last five games following an off day.
  • The under is 5-0 in Mikolas’ last five starts.
  • The over is 6-0 in the Dodgers’ last six Thursday games.
  • The Cardinals are 4-0 in Mikolas’ last four starts vs the National League West.
  • The over was 4-3 in these teams’ seven meetings last season.
  • The home team was 6-1 straight-up in these teams’ seven games in 2023.
  • The under is 4-0-1 in the Dodgers’ last five games against the National League Central.


Cardinals vs Dodgers Runline Pick: Dodgers -1½ Runs (-125)

The Dodgers have a couple of games under their belts, are playing at home and feature one of the most dangerous lineups in baseball, so it’s natural that the MLB spread picks should include them. Ohtani will have a big spotlight on him in his first home game with his new team, but the Dodgers’ offense was led last week by outfielder Mookie Betts, who had six hits, including a double and a home run, seven RBI and two runs scored in the two games in South Korea.

St. Louis has a pair of big-name hitters in third baseman Nolan Arenado and first baseman Paul Goldschmidt, but the Cardinals just won’t be able to match up with the Dodgers in this one. Mikolas will have to be at his very best to keep Los Angeles off the board, which doesn’t seem very likely.



Cardinals vs Dodgers Over/Under Pick: Over 8½ Runs (-120)

Five of these teams’ seven games against each other last season had nine or more runs scored combined. Now Los Angeles has added one of the best power hitters in the game in Ohtani (44 home runs, 95 RBIs in 2023) to its lineup, which is going to be trouble for the Cardinals.

St. Louis should be able to get some runs against Glasnow, who started against the Padres last week, allowing two earned runs in five innings in his first appearance with the Dodgers since coming from Tampa Bay in the offseason. The 30-year-old is going to be good for Los Angeles and helps improve its MLB playoff odds, but his first home game with his new team may not bring his best performance.



Cardinals vs Dodgers Team Prop Pick: Dodgers Over 5½ Runs (+110)

Mikolas begins his sixth season with the Cardinals coming off his highest ERA with St. Louis at 4.78. The 35-year-old can be great when he has his best stuff, but that has come less and less frequently since he had an 18-4 season in his first season with St. Louis in 2018. He’s gone 32-43 in the four seasons since.

The MLB spread picks are favoring the Dodgers for a reason in this one, and that’s the lineup of Betts, Ohtani, Freddie Freeman, Max Muncy and more that can light up a scoreboard. We expect that to happen in this one as Los Angeles cruises to an easy win.



Cardinals vs Dodgers Prediction

Dodgers 7, Cardinals 3



Questions Of The Day


Who won the season series between these teams in 2023?

The Dodgers won four of their seven meetings with the Cardinals in 2023, including all three games played at Dodger Stadium.

Is this the season opener for both teams?

Los Angeles actually opened its 2024 season with two games against the San Diego Padres in Seoul, South Korea, last week.

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