Nationals vs Dodgers Picks, Prediction, and MLB Prop Bets, Saturday 6/21: LA (-1.5) Too Much for Washington, 6

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• The Dodgers (-1.5) will show why they are tops in the MLB futures odds market.
• Back Japanese superstar Shohei Ohtani (+150) to hit a home run

The Dodgers and Nationals go at it again, with the MLB betting lines favoring host Los Angeles. The superstar team is the chalk for obvious reasons, and it’s hard to bet against it. Even if the Dodgers’ defense has not been that great, they’ve continued to win on the strength of an explosive offense. Washington can’t keep up, even if Jake Irvin pitches a clinic.

Tonight’s Photo of the Game presented by Daiso. pic.twitter.com/4zsQLZNvJc

— Los Angeles Dodgers (@Dodgers) June 19, 2025

Nationals vs Dodgers Prediction Today, June 21, 2025

• Nationals vs Dodgers Total Pick

Bet the over here, as 65% of the Dodgers’ home games (26-14-1) have per MLB betting trends. The hosts put up over six runs at Dodger Stadium, which leads the majors. Irvin has pitched well against L.A., but the bullpen will cough up runs with a collective ERA of 5.77 and 1.56 WHIP.

Bet on Nationals vs Dodgers Over 9.5 (-110)

• Nationals vs Dodgers Run Line Pick

We can lay nearly -300 on the Dodgers to win or parlay it. But for a straight-up pick, go with the run line. The Dodgers have the best home offense while Washington has a -70 run differential. L.A. is only 5-13 in its last 18 games against the run line since blowing out the Yankees 18-2. However, these MLB games have been against quality competition. Washington is not that.

Bet On Los Angeles Dodgers -1.5 (-130)

Nationals vs Dodgers Prop Picks and Best Bets

• Shohei Ohtani 1+ Home Runs (+150)

Shohei Ohtani is due to hit some dingers, especially at Dodger Stadium, where he’s batted with a 322/411/666 split (1.077 OPS). Irvin pitches well here. The Nats’ bullpen, despite giving up runs, tends to be good at limiting homers. But it’s Ohtani, and he’s got one of the best MLB player prop bets at plus odds.

Bet on Shohei Ohtani Home Run (+150)

Shohei Ohtani setting an example for the ENTIRE MLB last night… things got heated with the Dodgers and Padres, they were throwing at each other & emptying benches… Ohtani took it like a man and said this is part of the game guys… my hat’s off to him
pic.twitter.com/Gw2M7ENYLm

— John Frascella (Football) (@NFLFrascella) June 20, 2025

• Team With Most Hits – Los Angeles Dodgers (-182)

This is another gimme. The Dodgers top the majors in hits per game (9.3) while the Nats give up the fourth-most hits (8.8). Washington has also been cold, averaging only 7.1 hits this month and being held to seven or fewer in six of its last nine games. Los Angeles has also outhit Washington in nine of their last 10 meetings, per MLB news.

Bet on Dodgers for Most Hits (-182)

• Runs Scored in First Inning (YRFI) (-136)

Expect the Dodgers to get started fast here. Their 0.76 runs scored per 1st inning trails only Cincinnati, while they average nearly one run per home game, which tops the majors. Irvin can also take time to heat up. Batters average .277 with an .821 OPS and .474 SLG when he’s in his first 25 pitches. Bet YRFI.

Bet on YRFI (-136)

Bet These Nationals vs Dodgers Player Prop Picks Here

Nationals vs Dodgers How To Watch

• Game: Washington Nationals (31-44) vs Los Angeles Dodgers (46-30)
• Date/Time: Saturday, June 21, 10:10 p.m. ET
• Location: Dodger Stadium, Los Angeles, CA
• Nationals vs Dodgers Live Stream: MLB.tv

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets