Orioles vs Nationals Prediction, Picks and MLB Prop Bets, Thursday, 4/24

The Washington Nationals are looking to make MLB news today by sweeping a series from the Baltimore Orioles for the first time since 2021. The Nationals turn to MacKenzie Gore, one of three pitchers with at least 45 strikeouts this season, to seal the deal in Thursday’s series finale.

Baltimore is at -102 with the Nationals priced at -108 on the moneyline. Washington does offer some value at +176 on the -1.5 runline.

Luis Garcia, Jr. broke a 3-3 tie with a go-ahead sac fly in the bottom the 8th then @KyleFinnegan22 made it 9-for-9 in save tries as the @Nationals beat the @Orioles 4-3 to clinch a series win. @jwood_29 blasted 2nd career leadoff HR, a 431 foot shot with a career best 116.3… pic.twitter.com/BaLOgz5vxx

— Charlie Slowes (@CharlieSlowes) April 24, 2025

MLB futures bets have Baltimore tied for fourth among American League teams with +2200 odds of winning the World Series. Washington is well back at +25000 in the championship odds.

Orioles vs Nationals Prediction Today, April 24, 2025

My prediction

• Baltimore Orioles RL +1.5 (-205)

This has been a tough start for a Baltimore team expected to be one of the best squads in the American League. The Orioles are trying to avoid their first four-game losing streak of the season with lefty Cade Povich going after his first win of the season. He should be well-rested as he lasted less than four innings in his last outing. Keep that in mind when looking at the run spread betting options.

The Nationals are batting just .226 with a .347 slugging percentage against left-handed pitchers this season. Go with the Orioles cover when making MLB picks.

Bet on Orioles +1.5 (-205)

• Orioles vs Nationals Over 8.5 (-120)

The first two games in the series finished under the sports betting odds total as the teams are a combined 4-for-36 with runners in scoring position.

There have been at least 10 runs scored in four of Gore’s five starts this season. That is one of the reasons to go with the game going over 8.5 runs when making MLB predictions.

Bet on Orioles vs Nationals Over 8.5 (-120)

Orioles vs Nationals Prop Picks and Best Bets

• MacKenzie Gore Over 7.5 Strikeouts (+108)

Gore matched his season-high with 13 strikeouts in six innings in his last start. This will be Gore’s first start against the Orioles since 2023 when he allowed three hits and three runs and seven strikeouts in six innings.

MacKenzie Gore’s 7th K thru 4. pic.twitter.com/UtaWujYrCw

— Rob Friedman (@PitchingNinja) April 7, 2025

Take a look at the +108 odds for Gore to go over 7.5 strikeouts when making best MLB player prop picks today.

Bet on MacKenzie Gore to go over 7.5 strikeouts (+108)

• Cedric Mullins to Have 2+ Total Bases (+125)

Baltimore is batting just .168 as a team against lefties this season. Just imagine what that number would be without veteran outfielder Cedric Mullins, as he is 7-for-18 with three extra-base hits when facing a southpaw.

Mullins is coming off his sixth multi-hit game of the season, with six hits (three for extra bases) over the last five games.

Bet on Cedric Mullins to have 2+ Total Bases (+125)

• Orioles vs Nationals YRFI (-115)

Cade Povich has allowed three runs in the first inning in his first five starts of the season and he will be facing a Washington team that hit two home runs in the first inning on Wednesday. Gore has surrendered just one run with eight strikeouts in the opening frame in his five starts.

Baltimore and Washington rank in the top 10 in first-inning runs and in the top five in home runs surrendered in the first inning so far this season. That’s good enough for me to roll with the odds of having at least one run in the first inning when making MLB picks.

Bet on Score on First Inning – YES (-115)

Orioles vs Nationals How To Watch

• Game: Orioles (9-14) vs Nationals (11-13)
• Date/Time: Thursday, April 24, 6:45 p.m. ET
• Location: Nationals Park, Washington, DC
• Orioles vs Nationals Live Stream: MLB.tv

Click here for Orioles vs Nationals betting trends.

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Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.