Orioles vs Red Sox Prediction, MLB Prop Bets and Parlay Picks for Friday, 5/23: Bet Boston (-1.5) in Game 2

BetUS Locker Room Staff

· May 23 - 4 minutes read

Baltimore Orioles

Boston Red Sox

+1½ -170

Run Line

-1½ +148

+122

Moneyline

-135

O 9½ -120

Total

U 9½ Ev

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Orioles vs Red Sox Prediction, MLB Prop Bets and Parlay Picks for Friday, 5/23 — Cedric Mullins #31 of the Baltimore Orioles | Mitchell Layton/Getty Images/AFP

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Take the Red Sox (-1.5) to cover against the last-place Orioles in Game 2.
Bet Baltimore star Cedric Mullins for 2+ hits.

Orioles vs Red Sox Prediction and Best Bets Today, May 23

My prediction

Red Sox -1.5 Runs (+148)

After a Nor’Easter swept through Boston on Thursday, the Orioles and Red Sox are finally ready to do business today with a doubleheader. We’re focusing on the nightcap, when it figures to still be wet and cold. Not only is Baltimore 17-31 against the run line, but they’re facing an uncertain pitching situation. Trevor Rogers is the likely starter, per MLB news.

Begin your MLB parlay bets today by simply taking the Red Sox to cover at home.

Bet on Red Sox -1.5 Runs (+148)

Orioles vs Red Sox Over 9.5 Runs (-120)

Even with some clammy conditions on hand, the pitching matchup of Rogers and Boston’s Lucas Giolito could lead to some runs. The Orioles are quietly hitting .270 with 20 extra-base hits over their last six games and the Red Sox are seventh in the majors in runs scored. The MLB lines reflect this scenario with a rather high over/under mark to hit, but we think it’s within range.

Bet on Orioles vs Red Sox Over 9.5 Runs (-120)

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My Best Prop Bets

Cedric Mullins to Record 2+ Hits (+280)

Orioles hitters not named Cedric are hitting 9-for-54 (.167) against Giolito. Mullins, meanwhile, is a stunning 8-for-13 (.615) with four extra-base hits. Clearly, he’s a great guy to target with one of our best MLB player props today, and he’s coming in hot anyway. Mullins is 6-for-15 with two homers over his last four games.

If you’re feeling a bit shy just wager on one hit for the Baltimore center fielder. We’re feeling lucky with our MLB prop picks.

Bet on Cedric Mullins to Record 2+ Hits (+280)

Cedric Mullins ties it up in Milwaukee! pic.twitter.com/zANto2uHVP

— MLB (@MLB) May 20, 2025

Lucas Giolito Over 5.5 Strikeouts (+108)

Giolito has had an every-other-start thing going on so far, trading solid outings for clunkers through his first four outings. Not that it necessarily will continue that way, but he’s lined up for a good start in this one and will be facing the team with the third-highest strikeout rate in baseball. As we wrap up our MLB expert picks and parlays, we like this right-hander to pile up some Ks.

Bet on Lucas Giolito over 5.5 Strikeouts (+108)