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Padres Solid Pick to Beat Giants Again

The hitters hope that the sequel tops the original as the Giants and Padres were 6-for-20 with runners in scoring position in Thursday’s series opener. A four-run seventh inning lifted the Padres to the 6-4 win. The MLB latest lines list San Diego as the favorite at home against the Giants on Friday.

San Diego has won six of the last seven games against the Giants after Thursday’s 6-4 win. The previous five matchups had gone over the MLB ATS picks before Thursday’s series opener went over the 7½-run total. The Padres are also 6-1 in the last seven home games against the Giants.

Padres Solid Pick to Beat Giants Again
Padres Solid Pick to Beat Giants Again

The MLB betting lines list the Padres at +150 to cover the run line.

When looking at MLB futures odds, San Diego and San Francisco are both priced at +4000 in the odds of winning the World Series.


Giants vs Padres Game Information

  • Game: Giants (0-1) vs Padres (2-1)
  • Date/Time: Friday, March 29, 10:10 p.m. ET
  • Location: Petco Park, San Diego, CA
  • Giants vs Padres Live Stream: MLB.tv


San Francisco turns to 22-year-old starting pitcher Kyle Harrison. He allowed four home runs in 5⅔ innings in his only start against the Padres a season ago. Joe Musgrove will make his second start of the season after allowing seven hits and five runs in 2⅔ innings against the Dodgers.




San Diego is 6-1 in its last seven games as the home favorite with the Padres covering against the run line in five of those games. The Giants are 1-10 over the last 11 games as a road underdog.

San Diego is priced at -145 to win the game outright while the Giants are +130 in our sportsbook odds.

The Giants and Padres meet on Friday, March 29, at Petco Park in San Diego. You can watch the game on Apple TV+ at 10:10 p.m. ET.


Giants vs Padres Odds and Spreads


  • This will be the first game this season when the Padres are favored.
  • The total has gone under in nine of the last 10 games for the Giants.
  • Eleven of San Diego’s last 14 games went under the total.
  • Nine of San Francisco’s last 11 games against NL West teams went under the total.
  • Just two of San Francisco’s last 11 games against National League teams finished over the total.
  • Six of the last eight games that the Padres played against National League West teams went under the total.
  • Eight of San Diego’s last 11 games versus National League teams went under the total.


Giants vs Padres Over/Under Pick: Over 7½ (-120)

Things heated up in the series opener with six runs in the seventh inning as both bullpens had issues. The leadoff runner reached base four times each for the Giants and the Padres on Thursday. That is something to consider for MLB over/under predictions.



Giants vs Padres ATS Pick: Padres -1½ (+145)

With San Diego turning to veteran pitcher Joe Musgrove and San Francisco countering with a 22-year-old with seven career MLB appearances, the smart money will be on the host Padres to win the second of the four-game series between the National League West Division rivals.

San Francisco is just 2-15 in its last 17 road games while the Padres are 6-2 in their last eight games at home.

Relief pitcher Luke Jackson is questionable for the Giants while the Padres will be without reliever Glenn Otto.



Giants vs Padres Player Prop Pick: Fernando Tatis Jr. 2+ Runs and RBIs (+169)

Fernando Tatis Jr. had a single in the series opener. Look for him to do more damage in Game 2 as he looks for his first extra-base hit of the season. Take a look at the odds for Tatis to have at least two combined runs and RBIs for your player prop bets.

Tatis had five doubles and three home runs against the Giants in 2023 and he is due to deliver once again.



Giants vs Padres Prediction

Padres 5, Giants 3



Questions Of The Day

Which team has a better ATS record coming into the matchup between the Giants and the Padres?

San Diego was 81-80 against the run line last season compared to a 72-89 mark for the Giants.

What is a good player prop option for the San Francisco Giants?

Michael Conforto had three runs and three hits in the series opener so take a look at the -159 odds for Conforto to have at least one hit and the +229 odds for the outfielder to come through with two hits.


The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

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