Padres to Extend Winning Streak vs Diamondbacks
The San Diego Padres will try to keep their win streak going when they visit the Arizona Diamondbacks for a three-game series beginning Friday. The Padres will begin a road trip after winning their last series at home over Cincinnati, and they’ll look to start it strong and create some more separation with Arizona in the National League West standings. San Diego is tied for second in the division, just a game ahead of Arizona, but as a solid MLB pick for the opener.

Padres vs Diamondbacks Game Information
- Game: Padres (16-18) vs Diamondbacks (14-18)
- Location: Chase Field, Phoenix, AZ
- Day/Time: Friday, May 3, 9:40 p.m. ET
- Padres vs Diamondbacks Live Stream: MLB.tv
Padres vs Diamondbacks Moneyline Odds and Run Line
Padres vs Diamondbacks Betting Trends
- The Diamondbacks are 1-9 in series openers this season.
- The Padres are 8-6 on the road.
- The Padres have been chosen as underdogs in 13 games this year and have walked away with the win five times (38.5%) in those games.
- San Diego has a win-loss record of 5-6 when favored by -106 or worse by bookmakers this year.
- San Diego are 13-6 SU in their last 19 games on the road.
Cease and Desist
San Diego will try for its third straight win in its opener with Arizona, and it has a good shot with starter Dylan Cease on the mound.
Cease has gotten off to a good start this season for the Padres, going 3-2 with a 2.78 ERA and 0.87 WHIP. Although he is coming off his worst performance of the season, giving up five earned runs and a homer in six innings to the Phillies at home, Cease has been a stronger pitcher on the road.
In three games away from home, Cease is 2-0 with a 1.89 ERA and .115 opponent batting average. In his last two games on the road, both wins, he gave up two earned runs while throwing 15 strikeouts in 13 innings. Cease will aim to bounce back on the road and get the Padres off to a strong start with his recent play away from home.
Diamondbacks Failing to Get Key Hits
Cease should also be able to get off to a strong start due to the issues Arizona has had with scoring lately.
The Diamondbacks are eighth in the MLB with a .249 batting average and fourth with 151 RBIs, but they have struggled a bit more in their last two series. Arizona is coming off a shutout loss against the Dodgers after finishing with a .219 batting average in the game and it has averaged 2.2 runs a game in its last two series.
The biggest problem for the Diamondbacks is they do have trouble scoring runners. Arizona finished with a .107 batting average with runners in scoring position to leave 28 on base in its three-game series with the Dodgers. The Diamondbacks will need to figure out how to score in their series with San Diego to help them get back in the win column.
Road Team Prevails in Series Opener
MLB odds has the Padres-Diamondbacks as a near-tossup for the series opener, and though Arizona has home field, the Padres are the better choice in the opener.
After a five-game slide, San Diego has started to turn things around, winning its last two while its offense has started to pick up. The Padres have averaged 4.2 runs in their last five games, and with an inexperienced starter in Slade Cecconi for Arizona, they should be able to build off of that Friday.
San Diego’s Cease has also been pitching well this season, especially on the road, and he should be able to continue that against a D-Backs offense that can’t seem to score. With the Padres starting to put things together, they’re the better play on the road.
Padres vs Diamondbacks Prediction:
San Diego opens the series with a win (-105)
Questions Of The Day
How many games are in the series?
San Diego and Arizona will play a three-game series.
What is the total for the game?
The over/under is set at nine runs.
The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.