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Padres vs Blue Jays Prediction, MLB Prop Bets and Parlay Picks for Wednesday, May 21
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- Take Toronto -1.5 runs (+140) against ice-cold San Diego.
- Make a bet on Daulton Varsho to score 1+ Runs+RBIs (-130).
Padres vs Blue Jays Prediction and Best Bets Today, May 21
My prediction
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Run Line Pick: Blue Jays -1.5 Runs (+140)
There’s slumps, there’s big slumps and then there’s whatever is going on with the Padres, who have scored a total of three runs over their last four games. They have just five walks against 30 strikeouts in that span and it’s simply hard to bet in favor of them until there’s a turnaround. The MLB spreads reflect that by giving the edge to Toronto, which is 15-11-0 against the run line at home. We’re basing the best MLB parlay bets today on the Jays covering again.
Bet on Blue Jays -1.5 Runs (+140)
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Over/Under Pick: Padres vs Blue Jays Under 8.5 Runs (Ev)
Using some of the same logic offered above, we like a low-scoring affair. Heck, the Blue Jays had only three hits themselves in Tuesday’s 3-0 win over the Padres, two of them home runs to account for all the offense. The Randy Vasquez-Kevin Gausman matchup is a pretty good one and these trends should continue. The teams combine to land on the under nearly 56% of the time.
Vladimir Guerrero Jr. goes up the ladder and turns on one 💪 pic.twitter.com/ayjYiAzuvP
— MLB (@MLB) May 20, 2025
Get More MLB Game Picks, Expert Analysis and Best Bets
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My Best Prop Bets
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Daulton Varsho to Record 1+ Runs+RBIs (-130)
While searching for the best MLB player props today, we found that Varsho has five of his six homers at home this year and he’s 2-for-2 with a dinger and a double in his career against Vasquez. That’s about all you need to include this among your MLB player prop picks for Wednesday night.
Bet on Daulton Varsho to Record 1+ Runs+RBIs (-130)
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Luis Arraez 2+ Hits (+174)
Add the Varsho pick to this one to build up your MLB same game parlay picks and hope that history is on your side. As it relates to Arraez, that history vs Gausman is pretty dramatic; he’s 7-for-9 with a double against the veteran Jays hurler, an astounding measure of success that should lead you to paydirt.
Bet on Luis Arraez 2+ Hits (+174)
Padres vs Blue Jays Same Game Parlay Picks Today, May 21
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Padres vs Blue Jays How to Watch
- Game: San Diego Padres (27-19) vs Toronto Blue Jays (23-24)
- Date/Time: Wednesday, May 21, 7:05 p.m. ET
- Location: Rogers Centre, Toronto, ON
- Padres vs Blue Jays Live Stream: MLB.tv
Get the latest Padres vs Blue Jays betting trends here.
Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.
Padres vs Blue Jays MLB FAQs
What has the head-to-head looked like?
This is the eighth all-time series between the teams. There’s never been a sweep, with one or the other taking two of three each time. Toronto has won four of the last five games.
What other betting trends could impact this game?
Our MLB game predictions are also built upon the fact that Toronto is 13-9 against the run line after a win.
