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Padres vs Giants Game Preview, Live Stream, Odds, Picks & Predictions

Defending NL West Champions Eyeing Repeat

Talent-Laden Padres Dealing with Injuries

The San Diego Padres and San Francisco Giants are set to meet up on Monday in the first of 19 regular-season matchups between teams expected to be in the thick of the National League playoff race.

Alex Wood, who went 10-4 in his first season with the Giants, is set to make his season debut. Nick Martinez will be making his Padres debut and is set to pitch in the major leagues for the first time since taking the loss against Houston on Sept. 27, 2017, with the Texas Rangers so it is understandable why the MLB picks favor the Giants in the series opener.

APRIL 10: Dominic Leone #52 of the San Francisco Giants pitches against the Miami Marlins in the top of the ninth inning at Oracle Park on April 10, 2022 in San Francisco, California.
THEARON W. HENDERSON / GETTY IMAGES NORTH

Yu Darvish and Alex Cobb are the probable starting pitchers in Tuesday’s game while Sean Manaea and Logan Webb are set to square off in Wednesday’s series finale.

The Los Angeles Dodgers are the favorites to win the NL West title at -250 followed by the Padres (+325) and the Giants (+550).

Let’s check the latest MLB picks, stats, injury reports, and MLB odds for Padres vs Giants. We’ve plenty of MLB predictions.

Profar off to Red-Hot Start for Padres

The San Diego Padres are without MVP candidate Fernando Tatis Jr., but veteran outfielder Jurickson Profar is doing his best to fill the sizable void left by Tatis’ wrist injury.

Profar, who only hit .227 a season ago and has batted over .250 just twice in his first eight seasons, is hitting .400 with two homers and six RBIs. The Padres opened the season by taking three of four from Arizona.

Profar opened the scoring in Sunday’s 10-5 win with a grand slam as the Padres jumped out to a 10-0 lead to take the season-opening series.

Profar is hitting seventh in the order but that could change if he continues at his current pace.

While some of the established San Diego players didn’t exactly light up Arizona pitching, Profar and Austin Nola join Eric Hosmer as the Padres starters hitting at least .400.

The Las Vegas odds total has gone under in five of San Diego’s last seven games.

Giants Look to Get Hitters Going

The opening three-game series against Miami wasn’t exactly an offensive showcase for the San Francisco Giants.

None of the 11 players with at least five at-bats are hitting better than .275 going into the series with the Padres.

Darin Ruf, coming off a career-high 16 home run season, is the top hitter among the regulars with a .273 average.

The Giants did hit three homers against the Marlins but had a .172 team batting average. The good news is that Webb and Carlos Rodon gave up two earned runs and struck out 15 in 11 innings as San Francisco won two out of three from Miami.

Five of the eight relievers didn’t allow an earned run, with Jarlin Garcia and Jose Alvarez picking up wins in relief.

The Giants got a boost from Heliot Ramos, who had two hits and scored a run in his major league debut while Austin Slater’s RBI double in the 10th inning gave San Francisco a 6-5 win in the season opener.

The MLB betting online total has gone under in four of the Giants’ last six games.

Padres vs Giants Head-to-Head

San Francisco has won four of the last six meetings with San Diego, although the Giants have dropped three of the last five games against the Padres at home.

Something to consider for those who bet online: Three of the last six games between the teams have been one-run games while San Diego and San Francisco have combined for at least 11 runs in six of the last eight matchups.

Padres vs Giants Game Information

  • Game: Padres (3-1) vs Giants (2-1)
  • Location: Oracle Park, San Francisco, California
  • Day/Time: Monday, April 11th, 9:45 p.m. ET (teams also play on Tuesday and Wednesday)
  • Padres vs Giants Live Stream:MLB.tv

Padres vs Giants Betting Lines

Padres vs Giants Prediction

San Francisco starter Wood looks to pick up how he ended the 2021 season when he didn’t allow a run in three of his last four outings. Wood hasn’t pitched against the Padres since 2018 when he made four appearances – two as a starter and two in relief.

With much higher-profile pitching matchups on Tuesday and Wednesday, Monday’s opener could be the one when the offenses take center stage.  There’s a good chance of the game going over the MLB lines total of 8½.

With Blake Snell and Mike Clevinger both unable to go, Martinez gets the chance to show what he can do as San Diego’s starting pitcher. The Giants are in better shape from an injury standpoint, but veteran corner infielder Evan Longoria is out.

Pick: Over 8½ runs

Pick: San Francisco Giants -145

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