Red Sox vs Guardians Prediction, Picks and MLB Prop Bets, Friday 4/25

The Cleveland Guardians have been hard to beat at home this season with just two losses in nine games at Progressive Field. Can a Boston Red Sox team that is just 6-7 on the road make MLB news by changing that in Friday’s series opener?

For those who bet on MLB, the MLB betting line has Cleveland at +188 on the -1.5 run line compared to -220 odds for the Red Sox to cover as 1.5-run underdogs.

The MLB futures bets have the Red Sox holding steady at +1800 in the odds of winning the World Series. Cleveland’s championship odds have moved from +3300 to +5000 since the start of the season.

Red Sox vs Guardians Prediction Today, April 25, 2025

My prediction

• Moneyline Pick: Boston Red Sox ML (-105)
  

Boston probable starter Tanner Houck has an unseemly 7.66 earned run average. However, more than half of the runs he has given up came in a nightmarish outing against Tampa Bay. In his other three starts in April, he has allowed six runs in 16.2 innings. The 2024 All-Star allowed eight hits and two runs with 13 strikeouts in 15 innings in two starts against Cleveland last season. That figures into the MLB expert analysis for this matchup.

Bet on Red Sox ML (-105)

• Over/Under Pick: Red Sox Over 9 Runs (-105)

There have been 29 runs scored in the last two games started by Houck. Even though the Guardians have struggled at times to score at home, there were 18 runs scored the last two times that the Red Sox played in Cleveland. That is one of the reasons to go with the game going over 9 runs when making MLB predictions.

Bet on Red Sox vs Guardians Over 9 Runs (-105)

Red Sox vs Guardians Prop Picks and Best Bets

• Alex Bregman 2+ Total Bases (+112)

Alex Bregman has made MLB news with three consecutive multi-hit games with three extra-base hits and five RBIs in that stretch.

Alex Bregman sends this one WAY over The Green Monster! 💪 pic.twitter.com/HvQOHoccJS

— MLB (@MLB) April 24, 2025

Three of his four hits against Cleveland during the 2024 season went for extra bases.

Take a look at the +112 odds for Bregman to have 2+ total bases from hits when making MLB player prop picks today.

Bet on Alex Bregman to have 2+ Extra Bases (+112)

• Kyle Manzardo to Have 1+ Runs + RBIs (-107)

Five of Kyle Manzardo’s last six hits have been either doubles or home runs. He has four runs and seven RBIs during that stretch.

The Carlos Baerga Show is LIVE! #Guardians win series vs the Yankees, The Red Sox and Twins are coming to town & joined by Guardians first baseman, Kyle Manzardo! #GuardsBall https://t.co/McKJPBRFGW

— Carlos Baerga Show (@BaergaShow) April 24, 2025

Even though he is just 3-for-22 at home this season, two of those hits have been home runs.

Bet on Kyle Manzardo to have 1+ Runs + RBIs (-107)

• Red Sox vs Guardians NRFI (-120)

Ben Lively has not allowed a run in the first inning in his first five starts. However, Houck has given up nine hits and five runs in the opening frame this season.

Boston is batting .231 in the first inning this season. Cleveland is only slightly better at .241. That’s good enough for me to roll with the odds of not having any runs in the first inning when making MLB picks.

Bet on Score on First Inning – NO (-120)

Red Sox vs Guardians How to Watch

• Game: Red Sox (14-13) vs Guardians (14-10)
• Date/Time: Friday, April 25, 7:10 p.m. ET
• Location: Progressive Field, Cleveland, OH
• Red Sox vs Guardians Live Stream: MLB.tv

Click here for Red Sox vs Guardians betting trends.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.