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Tigers vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks Sept. 23

Slumping Chicago Tries to Turn it Around Against Detroit

Chicago on Three-Game Losing Streak

The Chicago White Sox look to avoid a fourth straight loss when they take on the visiting Detroit Tigers in the opener of a three-game weekend series on Friday night. Chicago was swept by the Cleveland Guardians this week, increasing their deficit behind the first-place Guardians in the AL Central race to seven games. Detroit had a two-game winning streak snapped with a loss to the Baltimore Orioles on Wednesday and is in last place in the AL Central standings. These division rivals have squared off a lot this season, so to prepare your bet online on this one, check out our in-depth preview of the contest.

Let’s check the latest MLB picks, stats, injury reports, and MLB odds for the Tigers vs White Sox. We’ve plenty of MLB predictions for you to consider.

Tigers vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks Sept. 23
Tigers vs White Sox Prediction, Game Preview, Live Stream, Odds & Picks Sept. 23

Tigers Providing Some Late Competition

As the Detroit Tigers try to avoid a 100-loss season, they’ve been putting up a fight against playoff contenders, taking two of three on the road this week against the Baltimore Orioles. Detroit wants a better showing against the Chicago White Sox than last weekend’s series, when they lost two of three, though two of the games went to extra innings.

Left-hander Eduardo Rodriguez will try to get things started right for Detroit when he makes his 15th start of the season on Friday. Rodriguez is 3-5 with a 4.35 ERA this season, striking out 59 in 72⅓ innings. He went 6⅓ innings against the White Sox on Saturday, allowing two runs on two hits while striking out seven and walking two.

Designated hitter Kerry Carpenter accounted for the Tigers’ only run in Wednesday’s loss to Baltimore with a solo home run, going 2-for-3 in the contest. The rookie is batting .275 with four doubles, a triple, six home runs, 10 RBIs, and 15 runs scored in 28 games.

White Sox Facing Must-Win Situations Going Forward

The margin for error for the Chicago White Sox is down to the minimum after getting swept by the first-place Cleveland Guardians this week. They can not afford more losses if they hope to make it back to the postseason this year.

“(The season) doesn’t come down to three games, but we knew what we had to do this series and we weren’t able to do it. It’s frustrating,” Chicago outfielder Gavin Sheets said after Thursday’s loss to Cleveland. “It’s not just this series; we had to play better all season.”

Sheets was 1-for-3 with a home run in the setback. He’s batting .244 with 18 doubles, 14 home runs, 50 RBIs, and 31 runs scored in 2022.

Designated hitter Eloy Jimenez was 1-for-4 with an RBI on Thursday, striking out twice. Jimenez is batting .309 with 11 doubles, 14 home runs, 51 RBIs, and 36 runs scored in 75 games.

Chicago will have right-hander Lucas Giolito on the mound for the series opener. Giolito is 10-9 with a 5.07 ERA in 27 starts, recording 158 strikeouts in 143⅔ innings. He struggled a bit in his last start, facing the Detroit Tigers on Sept. 16th, lasting 4⅔ innings and allowing a run on four hits while striking out five and walking three.

Tigers vs White Sox Head-To-Head

The Chicago White Sox have dominated the season series against the Detroit Tigers in 2022, taking 12 of the first 16 meetings. That’s reminiscent of the last couple of seasons, as Chicago won the season series 12-7 last year after going 9-1 against Detroit in 2020.

Playing at home has been a good thing for the White Sox against Detroit, as they are 25-7 at Guaranteed Rate Field against the Tigers since the start of the 2019 campaign. The MLB lines for Friday’s contest give Chicago the edge to keep that trend going with a win in the series opener.

Tigers vs White Sox Game Information

  • Game: Tigers (57-92) vs White Sox (76-74)
  • Location: Guaranteed Rate Field, Chicago
  • Day/Time: Friday, Sept. 23rd, 8:10 p.m. ET
  • Tigers vs White Sox Live stream:

Tigers vs White Sox Betting Lines

Team Handicap Moneyline Total Team Total
Detroit Tigers

E. Rodriguez -L

+1½ -150 +150 7-120o 3½+120o


Chicago White Sox

L. Giolito -R

+1½ -150 +150 7-120o 4½+120o


Tigers vs White Sox Prediction

The Chicago White Sox are feeling the pressure to come through with some wins, and they’ll be thankful to be facing the last-place Detroit Tigers this weekend. Look for the White Sox to come out with a big effort and win in Friday’s opener.

When making your MLB picks, take Chicago to get the win at home.

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