Picks, Prediction for Twins vs Astros on Wednesday, May 31
The Houston Astros hit a pair of home runs and chased Minnesota Twins star Joe Ryan in the series opener to remain three games out of first place in the American League West Division. The MLB picks favor Houston to take the final game of the three-game series.
Minnesota has the worst record of the six division leaders and joins the Milwaukee Brewers as the only division leader with a losing record on the road. Houston opened the season 3-6 and is 10 games over .500.

Houston is first and Minnesota second in the majors in team ERA. Keep that in mind when it comes time to make MLB predictions.
When looking at MLB news, relief pitcher Emilio Pagan is questionable for Minnesota while shortstop Jorge Polanco could return in early June.
Outfielder Michael Brantley continues to be sidelined for Houston.
Enjoy this quick look at the matchup before checking out our MLB lines.
Remember Me?
Carlos Correa had a better batting average on the road than at home during the first two seasons during his seven-year run with the Houston Astros. Those struggles in Houston have continued since joining the Minnesota Twins.
Correa is 1-for-9 with four strikeouts in the first two games of the series. In five games at Minute Maid Park as a member of the visiting team, Correa is 2-for-20 with eight strikeouts.
Correa does have at least one hit in six of his last seven games to bump his batting average from .201 to .211.
The MLB odds total has gone under in seven of the Twins’ last 10 games.
Dialing Long Distance
Alex Bregman hadn’t hit a home run in 10 games until taking an 0-2 pitch from Ryan deep in the third inning to open up the scoring for his seventh home run of the season.
Breggy Bomb salsa on Taco Tuesday. pic.twitter.com/ds8zjwFE7e
— Houston Astros (@astros) May 31, 2023
Bregman was on pace for 18 home runs going into the game, and for a player with seasons of 41, 31 and 23 home runs, his power supply has been running a bit low in the early stages of this season. Bregman is batting .450 with four runs and six RBIs during his six-game hitting streak.
Bregman is hitting .263 against Minnesota this season after batting .429 with four extra-base hits against the Twins in 2022.
When making your bet online, consider the fact that nine of Houston’s last 13 games against American League teams went under the total.
Starting Pitchers
Louie Varland (2-1, 4.24 ERA) vs Hunter Brown (5-1, 3.12)
Varland has allowed five home runs in his last three starts as he has surrendered 17 hits and eight runs over 17⅓ innings in those outings. This will be his first appearance against the Astros.
Brown is 2-0 with a 2.89 ERA in his last two starts. After not giving up a home run in his first six starts, he has allowed four over the last four games. Brown held Minnesota to two hits and one unearned run with seven strikeouts in seven innings on April 9, which is something to keep in mind for live betting options.
Twins vs Astros Head-to Head
Minnesota has won three of the last five meetings against Houston. The Twins are 2-5 in the last seven games in Houston.
Just one of the last 13 games between the Twins and Astros have been decided by one run.
The home team had won six of the last eight meetings.
Back-to-back games in the series haven’t gone over the MLB spreads total since 2019.
Twins vs Astros Game Information
- Game: Twins (28-27) vs Astros (32-22)
- Location: Minute Maid Park, Houston, TX
- Day/Time: Wednesday, May 31, 8:10 p.m. ET
- Twins vs Astros Live stream: MLB.tv
Twins vs Astros Betting Lines
Over/Under Pick
The Astros are 20th and the Twins 25th in the majors in batting average during the month of Ma. With that in mind, going with the game to finish under the eight-run total could be the way to proceed.
The Twins have scored seven runs in Varland’s last two starts with Houston scoring eight times in the last two games started by Brown.
Pick: Under 8 (Ev)
Moneyline Pick
Houston is starting to play with the swagger that comes with being the defending World Series champion. Brown has a 2.86 ERA in his four home starts and with a mostly healthy batting lineup, that is enough to give the Astros a chance to win.
Pick: Astros -175
Spread Pick
Each of the last seven times that Minnesota played in Houston, the game was decided by at least two runs. With that in mind, riding with Houston to cover would be the best way to proceed.
Plenty of money is coming in on Houston in the series finale even if the Astros are just 12-15 against the spread at home this season.
Pick: Astros -1½ (+115)