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Home » MLB Betting » MLB Picks » White Sox vs Guardians Predictions, Game Preview, Live Stream, Odds & Picks, April 20th

White Sox vs Guardians Predictions, Game Preview, Live Stream, Odds & Picks, April 20th

Teams to Double Up After Postponements

Ryan Knuppel by Ryan Knuppel
Apr 20, 2022, 10:39am ET
in MLB Picks
White Sox vs Guardians Predictions, Game Preview, Live Stream, Odds & Picks

White Sox vs Guardians Predictions, Game Preview, Live Stream, Odds & Picks

AL Central Foes Eager to Finally Play

After sitting around in Cleveland for the last two days and not being able to play due to weather postponements, the Chicago White Sox and Cleveland Guardians will battle twice on Wednesday.

Both teams will be eager to get back on the field and will be looking to make a statement in this shortened series.

Let’s dive into the MLB picks, stats, stories, and MLB odds for the White Sox vs. Guardians doubleheader.

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Let’s check the latest MLB Picks, stats, injury reports, and MLB Odds for White Sox vs Guardians. We’ve plenty of MLB Predictions.

White Sox Ready to Dominate

After two days of inclement weather, the Chicago White Sox will be looking to dominate the Guardians in a twin bill on Wednesday. The White Sox will look to have their offense firing on all cylinders.

If the offense is producing early on Wednesday, this could really help the White Sox in Game 2 and for the series finale on Thursday. The White Sox are in first place in the American League Central and can put some early distance between themselves and the Guardians.

Dallas Keuchel starts in Game 1 for Chicago while Game 2 will feature Jimmy Lambert, who will be making only the fifth start in his young career. He is looking to improve on a very average first start of the season that saw him last only three innings.

Guardians Need Surge

After a two-day weather break to mull things over and get a mental reset, the Cleveland Guardians are looking for a surge of power to get their ship back on track. A sweep of a doubleheader against the AL Central powerhouse White Sox could really boost their morale and get them headed in the right direction.

Shane Bieber will take the mound in Game 1, and this could really help the Guardians overall. He has had great success against the White Sox both last year and in his career. Look for that to continue.

In Game 2, the Guardians will send young gun Triston McKenzie to the mound. McKenzie has pitched both as a starter and out of the bullpen and is a great swing guy for just these types of situations.

He will look to extend a bit further than normal, having not pitched in seven days. Look for him to go five to six innings if he is feeling it out of the gate.

White Sox vs Guardians Head-to-Head

In 2021, the White Sox took the season series by a slim 10-9 margin over the Guardians. With this being an AL Central matchup, the White Sox need to step up their game against division rivals this MLB season.

MLB lines will be very different with this matchup as doubleheaders are always tough to predict for sportsbooks.

White Sox vs Guardians Game Information

  • Game: Chicago White Sox (6-3) vs Cleveland Guardians (4-5)
  • Location: Progressive Field, Cleveland, OH
  • Day/Time: Wednesday, April 20th 2:10 p.m. ET (Game 1); 5:40 p.m. ET (Game 2)
  • White Sox vs Guardians Live stream: MLB.tv
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White Sox vs Guardians Betting Lines


White Sox vs Guardians Prediction

With Bieber opposing Keuchel in the opener, look for the game to be a low-scoring pitcher’s duel. Both starters will be looking to go deep into the game to help conserve the bullpen for Game 2.

Ultimately, Bieber will outlast Keuchel and shut down the White Sox offense, as he has done for most of his career.

In Game 2, two young pitchers will be pitted against one another, and more than likely, the bullpens will come into play more here than they will in Game 1. Look for the offenses to hit their stride in Game 2 after being stifled in Game 1.

When you bet online for Wednesday’s games, take the Guardians to win Game 1 and the White Sox to slug out a win in Game 2.

Pick: Chicago White Sox +107 (Game 2)

BET THIS PICK: Chicago White Sox +107 (Game 2)
Tags: Chicago White SoxCleveland GuardiansMLB Picks
Ryan Knuppel

Ryan Knuppel

Ryan Knuppel has been writing about sports & sports betting topics online for over 15 years. He was a college basketball All-American in the early 2000's and has always had a deep understanding for sports. Ryan was the 2011 Buffalo Wild Wings National "Pickem" Winner which earned him a trip to play flag football with Jerry Rice and Deion Sanders. He was also a 2015 FanDuel.com Playboy Mansion NBA Championships Qualifier in daily fantasy sports. But his true claim to fame is the fact that he has played basketball with and against THE Michael Jordan numerous times in his life. Ryan is excited to be writing and covering sports here and would love to hear from you on social media.

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