Yankees vs Guardians Same Game Parlay Picks for April 21: Aaron Judge a Top Player Prop Pick

After meeting in the 2024 American League Championship Series six months ago, the stakes aren’t quite as high as when the New York Yankees and the Cleveland Guardians meet for the first time this season.

The MLB lines have -116 odds for New York to improve to 7-4 on the road while Cleveland comes in at +106 on the Moneyline, according to MLB odds today.

There are some MLB prop bets to consider when two of the top teams in the American League begin a three-game series.

Top 3 Yankees vs Guardians Parlay Picks

• New York Yankees ML (-116)

The Yankees are 8-4 outright against the Guardians during the regular season since the start of the 2023 season. With three of those wins coming by one run, taking the Yankees at -116 on the moneyline is a solid option when considering MLB same day parlay odds.

Bet on Yankees To Win Outright (-116)

• Aaron Judge to have 2+ Runs + RBIs (+100)

The home runs haven’t been coming for Aaron Judge. However, the reigning American League Most Valuable Player has 15 hits in his last nine games.

Score ✅
Salute ✅ pic.twitter.com/6UjiMiPAqC

— New York Yankees (@Yankees) April 20, 2025

The last time the Yankees played a regular-season series in Cleveland, Judge was 5 for 11 with four home runs, five runs, and seven RBIs. He is always a tempting option when making MLB prop picks today.

Bet on Aaron Judge to have 2+ Runs + RBIs (+100)

• Steven Kwan 1+ Total Bases (-278)

Kwan is 4-for-10 in his career against probable Yankees starter Clarke Schmidt. He is also hitting .349 over his last 10 games. Keep that in mind when it comes to MLB picks.

Steven Kwan and Kyle Manzardo hit two-run homers and Manzardo added a sacrifice fly in the 10th to rally the Cleveland Guardians to a 5-4 victory over the Pittsburgh Pirates for a three-game sweep.

RECAP: https://t.co/UHiSv1MIGc pic.twitter.com/65rBNHBpEx

— KDKA (@KDKA) April 21, 2025

Kwan at -278 to have 1+ total bases could be one of the best MLB parlay picks today to consider against the Yankees.

Bet on Steven Kwan to have 1+ total bases (-278)

Yankees vs Guardians How to Watch

• Game: Yankees (14-8) vs Guardians (12-9)
• Date/Time: Monday, April 21, 6:10 p.m. ET
• Location: Progressive Field, Cleveland, OH
• Yankees vs Guardians Live Stream: MLB.tv

Click here for Yankees vs Guardian stats.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.

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