Yankees vs Orioles Prediction, Picks and MLB Prop Bets, Monday, 4/28

The New York Yankees rebounded from losing a recent series to the Cleveland Guardians by taking the final two games from the Toronto Blue Jays. The Yankees will face another American League East team when they travel to Baltimore for the opener in a three-game series.

The road team won seven of the 13 games between the Yankees and the Orioles last season. The Yankees were favored in three of the seven games in Baltimore.

MLB odds today have New York at +125 on the -1.5 run line compared to -145 odds for the Orioles to cover.

MLB futures odds have the Yankees (+900) with the shortest odds of winning the World Series among American League teams. Baltimore’s championship odds have moved from +1600 to +3000 since the start of the season.

There are some MLB prop bets worth considering.

Yankees vs Orioles Prediction Today, April 28, 2025

My prediction

• New York Yankees ML (-126)

Baltimore lost its only other game this season when listed by BetUS Sportsbook as the home underdog. The Orioles are 4-7 on the run line at home.

Even though the Yankees are a much better team at home so far this season, it is hard to pick against the team with the second-best winning percentage in the American League.

Bet on Yankees ML (-126)

• Yankees vs Orioles Over 9 Runs (-125)

The Yankees lead the American League with 155 runs scored. No AL team has surrendered more runs than the Orioles. Isn’t that enough to roll with the series opener going over 9.5 runs when making MLB expert picks?

Bet on Yankees vs Orioles Over 9 (-125)

Yankees vs Orioles Prop Picks and Best Bets

• Anthony Volpe 2+ Total Bases (+123)

Facing the Toronto Blue Jays might have been just what the doctor ordered for struggling Yankees shortstop Anthony Volpe. He had two hits in each of the games in Sunday’s doubleheader and was 5-10 with three extra-base hits in the three games.

Anthony Volpe adds on for the @Yankees! pic.twitter.com/cvsVA0fzDL

— MLB (@MLB) April 27, 2025

Volpe made MLB news last season when four of his 10 hits when facing the Orioles were doubles.

Take a look at the +123 odds for Volpe to have 2+ total bases from hits when making MLB player prop picks today.

Bet on Anthony Volpe to have 2+ Total Bases (+123)

• Gunnar Henderson to Have 1+ Runs+RBIs (-129)

Gunnar Henderson scored 11 runs and drove in seven others against the Yankees last season and was 5-for-13 in the weekend series against the Tigers.

Gunnar Henderson slugs his first homer of the season 💪 pic.twitter.com/RBaAcawlso

— MLB (@MLB) April 17, 2025

When looking at MLB prop picks, consider the -129 odds for Henderson to come through with at least one run or one RBI.

Bet on Gunnar Henderson to have 1+ Runs+RBIs (-129)

• Yankees vs Orioles YRFI (-134)

The Orioles have failed to score in the first inning in their last seven games. The Yankees have at least one run in the opening inning in three of their last five games.

Will Warren of the Yankees didn’t allow a run in the first inning in his first five games. However, Tomoyuki Sugano has surrendered eight hits and six runs in the first inning in his five starts. Keep that in mind when making MLB picks.

Bet on Score on First Inning – YES (-134)

Yankees vs Orioles How To Watch

• Game: Yankees (17-11) vs Orioles (10-17)
• Date/Time: Monday, April 28, 6:35 p.m. ET
• Location: Oriole Park at Camden Yards, Baltimore, MD
• Yankees vs Orioles Live Stream: MLB.tv

Click here for Yankees vs Orioles betting trends.

Get More MLB Game Picks, Expert Analysis and Best Bets

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Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.