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76ers vs Knicks Game 2 Prediction, Odds and Picks Monday, April 22

The New York Knicks look to build on a rousing playoff win when they resume their first-round playoff series with the Philadelphia 76ers on Monday. New York took Game 1 of the series on Saturday, pulling out a 111-104 win for their sixth straight victory going back to the regular season. The second-seeded Knicks are being made an NBA expert prediction for a run to the Eastern Conference finals by many.

But standing in the way is Philadelphia, which played well but inconsistently. Part of that was center Joel Embiid, who was good on the court but spent some time out with an injury scare. The 76ers were much better with their big center on the floor, so they need him to stay healthy for the rest of the series.

76ers vs Knicks Game 2 Prediction, Odds and Picks Monday, April 22
76ers vs Knicks Game 2 Prediction, Odds and Picks Monday, April 22

This will be a hard-fought series, and Philadelphia would love to tie the series before going home for Games 3 and 4. Check out our NBA betting preview of this contest to help you determine how to make your wagers.

Here’s a look at some NBA Lines and NBA Game Odds to consider!

76ers vs Knicks Game Information

  • Game: 76ers (0-1) vs Knicks (1-0)
  • Start Time: 7:30 p.m. ET
  • Day Game: Monday, April 22
  • Location: Madison Square Garden, New York, NY
  • 76ers vs Knicks Live Stream: NBA Game Pass


The Knicks won the regular-season series between these squads, taking three out of the four meetings. This is the first time the teams have faced each other in the playoffs since the 1989 postseason, with New York sweeping a first-round series in three games.

The NBA odds favor the Knicks to take Game 2, with New York giving five points to Philadelphia. If you bet the moneyline, you can get the Knicks at -200 and the 76ers at +170. The over/under for Game 2 has been set at 209 points..

Game 2 is on Monday, April 22, at 7:30 p.m. ET from Madison Square Garden in New York. You can catch the action live on TNT and MAX.

76ers vs Knicks Head-to-Head



76ers vs Knicks Odds and Spreads




  • Philadelphia is 10-2 ATS in its last 12 games.
  • New York is 7-3 ATS in its last 10 games played on a Monday.
  • The total has gone under in four of the Knicks’ last five games against the 76ers.
  • Philadelphia is 5-1 ATS in its last six games on the road.
  • New York is 4-11 straight-up in its last 15 games when playing at home against Philadelphia.
  • The total has gone over in the Knicks’ last six games.
  • The 76ers are 24-18 ATS on the road this season.
  • The over is 16-26 in the Knicks’ 42 games at home in 2023-24.


76ers vs Knicks Over/Under Pick: Over 209 (-110)

The most amazing thing about the Knicks’ win on Saturday was that it happened despite All-Star guard Jalen Brunson having an off game. He did finish with 22 points, seven rebounds, and seven assists, so he wasn’t completely off, but his shooting was. Brunson was 8-of-26 from the floor, including 1-of-6 from 3-point range, numbers that should improve in Game 2.

Both teams will be more into the series as familiarity sets in. Look for a more even-flowing game, which means more scoring. Make the over a best bet NBA on your wagering for Monday.


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76ers vs Knicks ATS Pick: 76ers +5

Trying to pick a winner in Game 2 isn’t easy, but we like Philadelphia to keep things close, whether it goes down 0-2. The more Embiid plays and gets used to his surgically-repaired knee, the better he and the 76ers will be. The 7-footer was able to go 37 minutes despite a scare in the second quarter that kept him out for the rest of the first half, finishing with 29 points, eight rebounds and six assists.

Guard Tyrese Maxey was good in Game 1 for Philadelphia, scoring a game-high 33 points and getting to the basket almost at ease. Maxey and Embiid must lead the scoring attack for Philadelphia. Our NBA expert prediction is that both will have big games on Monday to keep things close if not get the 76ers the win.



76ers vs Knicks Prop Pick: Kyle Lowry Over 2½ Assists (-112)

Some of the best NBA betting doesn’t come on the superstars but on the role players that quietly put up numbers that can get you wins. An example of that is a prop bet on 76ers guard Kyle Lowry to dish out at least three assists in Game 2. Lowry had two assists in Game 1, but he’s averaging 4.2 per game and had eight in the regular-season finale against Brooklyn. Look for the veteran to come up with a better effort distributing the ball in Game 2.



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76ers vs Knicks Score Prediction

Knicks 112, 76ers 109



Questions of the Day

Who won the regular-season series between the 76ers and Knicks?

The Knicks took three of four regular-season meetings with the 76ers in 2023-24.

When was the last time the 76ers and Knicks played in the postseason?

The last time these teams faced each other in the playoffs was 1989, with New York earning a three-game sweep in the first round.

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