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Cavaliers vs Timberwolves Prediction, Odds and NBA Picks Friday, March 22

We have NBA expert picks for the Cleveland Cavaliers-Minnesota Timberwolves game on Friday night.

The Cavaliers are without Donovan Mitchell and the Timberwolves miss Karl-Anthony Towns, so it’s all hands on deck to make up for their loss.

Cavaliers vs Timberwolves Prediction,Odds and Picks Friday, March 22
Cavaliers vs Timberwolves Prediction,Odds and Picks Friday, March 22


Cavaliers vs Timberwolves Game Information

  • Game: Cavaliers (43-26) vs Timberwolves (47-22)
  • Start Time: Friday, March 22
  • Day Game: 8 p.m. ET
  • Location: Target Center, Minneapolis
  • Cavaliers vs Timberwolves Live Stream: NBA Game Pass


The Timberwolves have mixed form since losing Towns, but they are -7 favorites to beat the Cavaliers on Friday night at Target Center. The total is 208.


Cavaliers vs Timberwolves Head-to-Head


Cavaliers vs Timberwolves Odds and Spreads



  • The Cavaliers are 23-18-1 ATS with one day off.
  • The Cavaliers are 17-15-1 ATS on the road.
  • The under is 9-6 when the Cavaliers are road underdogs.
  • The under is 16-9 when the Cavaliers come off a loss.
  • The Timberwolves are 13-8 ATS following a loss.
  • The Timberwolves are 11-15-2 ATS as the home favorite.
  • The over is 13-11 in the Timberwolves’ non-conference games.
  • The under is 14-5-1 when the Timberwolves have the rest advantage.


Cavaliers vs Timberwolves Over/Under Pick: Over 208

Bettors get a value total at 208, and we’re including it in our NBA picks for Friday’s game.

We’re going against many of the betting trends as the Cavaliers and Timberwolves are due a big scoring game. The Timberwolves have scored in the 110s for four straight contests.

A similar performance should see the total go over the mark, and sport betting markets are being generous.



Cavaliers vs Timberwolves ATS Pick: Timberwolves -7

Our sportsbook has the Timberwolves at -7, and we’re comfortable picking the home team to cover.

They might come off a loss, but it was 115-112 to the Denver Nuggets, who are one of the better teams in the NBA.

We don’t rate the Cavaliers in the same manner, and they have mixed form since Mitchell went down with an injury.

Our NBA picks against the spread have Minnesota getting back to its best.



Cavaliers vs Timberwolves Player Prop Pick: Anthony Edwards Over 29½ Points

Having Anthony Edwards in your NBA prop picks is a recipe for success, and he has been money this year.

The Timberwolves best scorer comes off totals of 37, 31, 32 and 30 points, and we think he hits that mark again.



The Cavaliers defense isn’t easy to get past, but Edwards is one of the best natural scorers in the NBA, so he doesn’t need screens to get open.

He should get plenty of chances to put points on the board, and there’s seemingly no slowing him down, especially with Towns off the floor.


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Cavaliers vs Timberwolves Prediction

Minnesota Timberwolves 111, Cleveland Cavaliers 105



Questions Of The Day

Is the injury to Towns more important to the Timberwolves than Mitchell’s to Cleveland?

We think the injury to Mitchell has a worse impact on their chances of winning. The Timberwolves have a deeper roster, so they can cope.

Is Anthony Edwards in the running for MVP?

Odds are available for Anthony Edwards to win the NBA MVP title, but he’s unlikely to garner enough votes.


The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

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