Cavaliers vs 76ers Game Preview, Odds, Picks & Predictions
Visiting Cleveland Looks to End Philadelphia's Streak
76ers Rolling
The Philadelphia 76ers are in the midst of a four-game winning streak and they’ll be looking to make it five in a row this Friday when the Cleveland Cavaliers descend on the Wells Fargo Center in Philadelphia. The Cavaliers are riding a two-game losing streak and desperate to get back in the win column.
BetUS sportsbook has rolled out NBA betting markets that are firmly cornered with the hosts, including a 7½-point spread. Will the Sixers come through with the win and cover or can the Cavaliers pull off a statement win on the road?

Cavaliers Look to Halt Slide
The Cleveland Cavaliers have lost two in a row and five of their last six games to slip to 5-5 in their last 10 games. This recent drop in form is a serious cause for concern because the Toronto Raptors are breathing down their necks in the standings, two games back of the Cavaliers and automatic entry into the playoffs.
Back-to-back losses at home to the Minnesota Timberwolves (127-122) and to the Charlotte Hornets (119-98) were the latest setbacks for Cleveland. The Cavaliers closed as the 3½-point underdogs to the Timberwolves and the -4 favorites against the Hornets on the NBA odds board, respectively. In both cases, though, they failed to whiff at the point spread, although Wednesday’s lopsided loss against the Hornets was especially disappointing.
Another buzzer-beater for DG the PG 👌@betwayusa | #LetEmKnow pic.twitter.com/AwY23xvgF3
— Cleveland Cavaliers (@cavs) March 3, 2022
Overall, the Cavaliers are 36-26 straight up (SU) and in sixth place in the Eastern Conference standings. They’re five games back of conference-leading Miami Heat and merely 2½ games back of the Sixers. In the context of betting, the Cavaliers are 34-25-3 against the spread (ATS).
On the road, the Cavaliers are 17-15 SU and 17-13-2 ATS with a 1.7 winning margin on average and a +3.8 differential versus the spread.
Sixers Eye Fifth Straight Win
The Philadelphia 76ers are surging behind a four-game winning streak that sees them improving to a solid 7-3 SU and 6-4 ATS record in their last 10. The Sixers (38-23) are second in the Eastern Conference and 2½ games behind the first-place Miami Heat.
Most recently, the Sixers swept the New York Knicks in back-to-back games. They beat the Knicks 125-109 on the road, covering as the 7½-point road favorites, and 123-108 as the -10½-point home chalk. Before that, the Sixers upset the defending NBA champions Milwaukee Bucks 123-120 as the +6½ underdogs and the Minnesota Timberwolves 133-102 as the -2½ favorites for NBA picks and predictions.
Maxey made it rain last night. ☔ pic.twitter.com/hbO06t2Mvz
— Philadelphia 76ers (@sixers) March 3, 2022
The Sixers are 32-29-0 ATS with a 2.5 winning margin on average and a -0.2 differential versus the spread. At home, the Sixers are 17-13 SU and merely 12-180 ATS with a 2.5 winning margin and -2.6 differential versus the spread. As the home favorite, the Sixers are merely 9-13-0 ATS and with a -1.4 differential versus the spread, despite boasting a 6.5 winning margin on average.
Cavaliers vs 76ers Head-to-Head
The Cleveland Cavaliers boast a discouraging 3-7 record in the last 10 against the Philadelphia 76ers but they’re 5-5-0 ATS over the same span. The under has cashed in seven of their last 10 games, including two straight going back to last season.
The Sixers won both of the last two meetings, beating the Cavaliers 114-94 on April 1, 2021. They followed that up with a 103-93 win last month at the Wells Fargo Center, coming through as the closing 2½-point home chalk in betting online markets.
Cavaliers vs 76ers Game Information
- Game: Cleveland Cavaliers (36-26) at Philadelphia 76ers (38-23)
- Location: Wells Fargo Center, Philadelphia
- Day/Time: Friday, 7 p.m. ET
- Television: ESPN
Cavaliers vs 76ers Betting Lines
Cavaliers vs 76ers Prediction
In all likelihood, the Philadelphia 76ers are the smart bet to win this game. They have the commanding head-to-head advantage, the form and home-court advantage – all aspects that underscore their odds at the sportsbook exchange.
That said, if the betting trends were any indication, the Sixers aren’t performing well against the spread and especially at home. This is a function of many things, including the market overvaluing their odds as one of the public favorites right now.
Whether this trend holds true on Friday remains to be seen, but it certainly does make a punt on the Cleveland Cavaliers worth considering. The Cavaliers have had success keeping games close on the road. Add to that the pressure that comes at this stage of the season with playoff berths on the line, the Cavaliers will be incentivized to give the 76ers a run for their money.