Pistons vs Knicks Prediction, Picks and 2025 NBA Playoff Odds for April 19: Bet New York (-7)

The New York Knicks are a solid 7-point favorite in the NBA betting lines as they prepare to host the Detroit Pistons for Game 1 of their best-of-seven Eastern Conference first-round series.

The Knicks dropped three of their last four to end the regular season, but finished with the most wins (51) since 2012-13. New York is +3000 in the NBA Championship odds and starts the playoffs relatively healthy.

Detroit won 44 games after combining for 31 in the previous two seasons and returns to the playoffs for the first time since 2018-19. The Pistons have beaten the Knicks in their last three tries, but are +295 in the NBA playoff odds to win the series.

Pistons vs Knicks NBA Playoff Prediction

Knicks 120, Pistons 108

Detroit beat the Knicks at the Garden both times this season, per NBA betting tips, and are bound to make these first two games tough. However, New York should be primed and ready to go for Game 1 and the Pistons went 2-6 in their last eight games. Take the Knicks to pull away.

Pistons vs Knicks Best Player Props Today

• Karl-Anthony Towns 24+ Points (-110)

Karl-Anthony Towns will be pumped up for his first playoff game with the Knicks. The 7-foot center had 25 points and 10 rebounds versus Detroit on April 10 and is currently on a streak of 11 straight double-doubles (one triple). We like New York’s other inside-outside force OG Anunoby, but he is coming off a thumb injury, so he is a wait-and-see bet.

• Cade Cunningham 3+ Made 3-Pointers (+167)

Cade Cunningham is Detroit’s offensive catalyst and he has had great success against the Knicks this season, averaging 30.8 points. The former first overall draft pick has also been on target from long range, draining 13 behind the arc in four games versus New York. Include the 6-6 guard in your NBA picks for today for his first career postseason game.

Cade Cunningham over his last 3 games:

36 PTS – 12 AST – 71% FG
36 PTS – 8 AST – 67% FG
35 PTS – 3 REB – 5 AST

(Via @realapp_ ) pic.twitter.com/sZ4t15Ki2J

— NBACentral (@TheDunkCentral) April 12, 2025

• Josh Hart 7+ Assists (+116)

Knicks point guard Josh Hart had a solid playoff run in 2024 and was a major distributor in the last four games this regular season, collecting 41 assists. Hart scored 14.5 per game in the postseason a year ago, but has even more scoring options to set up this time. It looks like a good NBA matchup for him.

Bet These Pistons vs Knicks Player Props Here

Pistons vs Knicks Moneyline Pick

The Pistons certainly found the answers against the Knicks the last three times they met, but the playoffs are a different animal. Detroit struggled down the stretch, perhaps because of the injury to second-leading scorer Jaden Ivey (17.6). The Knicks just have more weapons, especially with the home fans behind them.

Bet on Knicks ML (-285)

Pistons vs Knicks Spread Pick

This one is not an easy NBA prediction. We expect the Pistons to make a serious run at either Game 1 or 2. The first contest of the series looks like it could be a more emotional one with New York at home and Detroit looking for its first playoff win since 2008. Jalen Brunson is averaging 28.3 points versus the Pistons this season and should lead the way again.

Bet on Knicks -7 points (-110)

Jalen Brunson’s historic playoffs last season:

42.0 PPG
9.4 APG
50.0% FG

The only player in NBA playoff history to record these number over a 5-game span.

Playoff 11, returns next week.
pic.twitter.com/gnfyzvP2ux

— BrunsonMuse (@BrunsonMuse) April 13, 2025

Pistons vs Knicks Over/Under Pick

The teams averaged more than 231 points per game during the regular season, but the playoffs can be a bit tighter. The number is still low enough to beat with Towns, Brunson, Anunoby and Mikal Bridges (19.8 points versus Detroit this season) leading the Knicks. Cunningham will get support from Malik Beasley, Tobias Harris and Tim Hardaway Jr. – all playoff veterans.

Bet on Pistons vs Knicks Over 220 ½ (-110)

Pistons vs Knicks How to Watch

• Game: Detroit Pistons vs New York Knicks
• Date/Time: Saturday, April 19, 6:00 p.m. ET
• Location: Madison Square Garden, New York, N.Y.
• Pistons vs Knicks Live Stream: NBA League Pass.

Get the latest Pistons vs Knicks stats here.

Looking for more ways to bet on NBA today’s games? BetUS has you covered with NBA 1st half lines, NBA 2nd-half lines, and NBA 1st quarter lines. Head over to our sportsbook page to see all your options.

Odds and information are accurate at the time of writing. Please check with official sources for the latest updates before placing any bets.

More Pistons vs Knicks NBA Picks and Best Bets Today

• Pistons vs Knicks NBA Playoffs First Round Same Game Parlay Picks for April 19: Harris (17+) is Top Point Prop

Questions of the Day