2021 NFL Matchup Schedule
| Date | Time ( ET) | NFL Matchup |
| Thursday, September 23rd | 6:20 PM | Carolina Panthers vs Houston Texans |
| Sunday, September 26th | 11:00 AM | Indianapolis Colts vs Tennessee Titans |
| Sunday, September 26th | 11:00 AM | Atlanta Falcons vs New York Giants |
| Sunday, September 26th | 11:00 AM | Los Angeles Chargers vs Kansas City Chiefs |
| Sunday, September 26th | 11:00 AM | Cincinnati Bengals vs Pittsburgh Steelers |
| Sunday, September 26th | 11:00 AM | Chicago Bears vs Cleveland Browns |
| Sunday, September 26th | 11:00 AM | Baltimore Ravens vs Detroit Lions |
| Sunday, September 26th | 11:00 AM | New Orleans Saints vs New England Patriots |
| Sunday, September 26th | 11:00 AM | Arizona Cardinals vs Jacksonville Jaguars |
| Sunday, September 26th | 11:00 AM | Washington Football Team vs Buffalo Bills |
| Sunday, September 26th | 2:25 PM | New York Jets vs Denver Broncos |
| Sunday, September 26th | 2:25 PM | Miami Dolphins vs Las Vegas Raiders |
| Sunday, September 26th | 2:25 PM | Seattle Seahawks vs Minnesota Vikings |
| Sunday, September 26th | 2:25 PM | Tampa Bay Buccaneers vs Los Angeles Rams |
| Sunday, September 26th | 6:20 PM | Green Bay Packers vs San Francisco 49ers |
| Monday, September 27th | 6:15 PM | Philadelphia Eagles vs Dallas Cowboys |
| Date | Time ( ET) | NFL Matchup |
| Thursday, September 30th | 6:20 PM | Jacksonville Jaguars vs Cincinnati Bengals |
| Sunday, October 3rd | 11:00 AM | Tennessee Titans vs New York Jets |
| Sunday, October 3rd | 11:00 AM | Kansas City Chiefs vs Philadelphia Eagles |
| Sunday, October 3rd | 11:00 AM | Carolina Panthers vs Dallas Cowboys |
| Sunday, October 3rd | 11:00 AM | New York Giants vs New Orleans Saints |
| Sunday, October 3rd | 11:00 AM | Cleveland Browns vs Minnesota Vikings |
| Sunday, October 3rd | 11:00 AM | Detroit Lions vs Chicago Bears |
| Sunday, October 3rd | 11:00 AM | Houston Texans vs Buffalo Bills |
| Sunday, October 3rd | 11:00 AM | Indianapolis Colts vs Miami Dolphins |
| Sunday, October 3rd | 11:00 AM | Washington Football Team vs Atlanta Falcons |
| Sunday, October 3rd | 2:25 PM | Seattle Seahawks vs San Francisco 49ers |
| Sunday, October 3rd | 2:25 PM | Arizona Cardinals vs Los Angeles Rams |
| Sunday, October 3rd | 2:25 PM | Pittsburgh Steelers vs Green Bay Packers |
| Sunday, October 3rd | 2:25 PM | Baltimore Ravens vs Denver Broncos |
| Sunday, October 3rd | 6:20 PM | Tampa Bay Buccaneers vs New England Patriots |
| Monday, October 4th | 6:15 PM | Las Vegas Raiders vs Los Angeles Chargers |
| Date | Time ( ET) | NFL Matchup |
| Thursday, October 7th | 6:20 PM | Los Angeles Rams vs Seattle Seahawks |
| Sunday, October 10th | 11:00 AM | New York Jets vs Atlanta Falcons |
| Sunday, October 10th | 11:00 AM | Detroit Lions vs Minnesota Vikings |
| Sunday, October 10th | 11:00 AM | New Orleans Saints vs Washington Football Team |
| Sunday, October 10th | 11:00 AM | New England Patriots vs Houston Texans |
| Sunday, October 10th | 11:00 AM | Miami Dolphins vs Tampa Bay Buccaneers |
| Sunday, October 10th | 11:00 AM | Green Bay Packers vs Cincinnati Bengals |
| Sunday, October 10th | 11:00 AM | Denver Broncos vs Pittsburgh Steelers |
| Sunday, October 10th | 11:00 AM | Philadelphia Eagles vs Carolina Panthers |
| Sunday, October 10th | 11:00 AM | Tennessee Titans vs Jacksonville Jaguars |
| Sunday, October 10th | 2:25 PM | Cleveland Browns vs Los Angeles Chargers |
| Sunday, October 10th | 2:25 PM | Chicago Bears vs Las Vegas Raiders |
| Sunday, October 10th | 2:25 PM | San Francisco 49ers vs Arizona Cardinals |
| Sunday, October 10th | 2:25 PM | New York Giants vs Dallas Cowboys |
| Sunday, October 10th | 6:20 PM | Buffalo Bills vs Kansas City Chiefs |
| Monday, October 11th | 6:15 PM | Indianapolis Colts vs Baltimore Ravens |
| Date | Time ( ET) | NFL Matchup |
| Thursday, October 14th | 6:20 PM | Tampa Bay Buccaneers vs Philadelphia Eagles |
| Sunday, October 17th | 11:00 AM | Miami Dolphins vs Jacksonville Jaguars |
| Sunday, October 17th | 11:00 AM | Kansas City Chiefs vs Washington Football Club |
| Sunday, October 17th | 11:00 AM | Los Angeles Rams vs New York Giants |
| Sunday, October 17th | 11:00 AM | Houston Texans vs Indianapolis Colts |
| Sunday, October 17th | 11:00 AM | Cincinnati Bengals vs Detroit Lions |
| Sunday, October 17th | 11:00 AM | Green Bay Packers vs Chicago Bears |
| Sunday, October 17th | 11:00 AM | Los Angeles Chargers vs Baltimore Ravens |
| Sunday, October 17th | 11:00 AM | Minnesota Vikings vs Carolina Panthers |
| Sunday, October 17th | 2:25 PM | Arizona Cardinals vs Cleveland Browns |
| Sunday, October 17th | 2:25 PM | La Vegas Raiders vs Denver Broncos |
| Sunday, October 17th | 2:25 PM | Dallas Cowboys vs New England Patriots |
| Sunday, October 17th | 6:20 PM | Seattle Seahawks vs Pittsburgh Steelers |
| Monday, October 18th | 6:15 PM | Buffalo Bills vs Tennessee Titans |
| Date | Time ( ET) | NFL Matchup |
| Thursday, October 21st | 6:20 PM | Denver Broncos vs Cleveland Browns |
| Sunday, October 24th | 11:00 AM | Carolina Panthers vs New York Giants |
| Sunday, October 24th | 11:00 AM | New York Jets vs New England Patriots |
| Sunday, October 24th | 11:00 AM | Kansas City Chiefs vs Tennessee Titans |
| Sunday, October 24th | 11:00 AM | Washington Football Team vs Green Bay Packers |
| Sunday, October 24th | 11:00 AM | Atlanta Falcons vs Miami Dolphins |
| Sunday, October 24th | 11:00 AM | Cincinnati Bengals vs Baltimore Ravens |
| Sunday, October 24th | 2:05 PM | Detroit Lions vs Los Angeles Rams |
| Sunday, October 24th | 2:05 PM | Philadelphia Eagles vs las Vegas Raiders |
| Sunday, October 24th | 2:25 PM | Houston Texans vs Arizona Cardinals |
| Sunday, October 24th | 2:25 PM | Chicago Bears vs Tampa Bay Buccaneers |
| Sunday, October 24th | 6:20 PM | Indianapolis Colts vs San Francisco 49ers |
| Monday, October 25th | 6:15 PM | New Orleans Saints vs Seattle Seahawks |
| Date | Time ( ET) | NFL Matchup |
| Thursday, October 28th | 6:20 PM | Green Bay Packers vs Arizona Cardinals |
| Sunday, October 31st | 11:00 AM | Cincinnati Bengals vs New York Jets |
| Sunday, October 31st | 11:00 AM | Tennessee Titans vs Indianapolis Colts |
| Sunday, October 31st | 11:00 AM | Los Angeles Rams vs Houston Texans |
| Sunday, October 31st | 11:00 AM | Pittsburgh Steelers vs Cleveland Browns |
| Sunday, October 31st | 11:00 AM | Philadelphia Eagles vs Detroit Lions |
| Sunday, October 31st | 11:00 AM | San Francisco 49ers vs Chicago Bears |
| Sunday, October 31st | 11:00 AM | Carolina Panthers vs Atlanta Falcons |
| Sunday, October 31st | 11:00 AM | Miami Dolphins vs Buffalo Bills |
| Sunday, October 31st | 2:05 PM | New England Patriots vs Los Angeles Chargers |
| Sunday, October 31st | 2:05 PM | Jacksonville Jaguars vs Seattle Seahawks |
| Sunday, October 31st | 2:25 PM | Washington Football Team vs Denver Broncos |
| Sunday, October 31st | 2:25 PM | Tampa Bay Buccaneers vs New Orleans Saints |
| Sunday, October 31st | 6:20 PM | Dallas Cowboys vs Minnesota Vikings |
| Monday, November 1st | 6:15 PM | New York Giants vs Kansas City Chiefs |
| Date | Time ( ET) | NFL Matchup |
| Thursday, November 4th | 6:20 PM | New York Jets vs Indianapolis Colts |
| Sunday, November 7th | 12:00 PM | Atlanta Falcons vs New Orleans Saints |
| Sunday, November 7th | 12:00 PM | Denver Broncos vs Dallas Cowboys |
| Sunday, November 7th | 12:00 PM | New England Patriots vs Carolina Panthers |
| Sunday, November 7th | 12:00 PM | Minnesota Vikings vs Baltimore Ravens |
| Sunday, November 7th | 12:00 PM | Cleveland Browns vs Cincinnati Bengals |
| Sunday, November 7th | 12:00 PM | Buffalo Bills vs Jacksonville Jaguars |
| Sunday, November 7th | 12:00 PM | Houston Texans vs Miami Dolphins |
| Sunday, November 7th | 12:00 PM | Las Vegas Raiders vs New York Giants |
| Sunday, November 7th | 3:05 PM | Los Angeles Chargers vs Philadelphia Eagles |
| Sunday, November 7th | 3:25 PM | Green Bay Packers vs Kansas City Chiefs |
| Sunday, November 7th | 2:25 PM | Arizona Cardinals vs San Francisco 49ers |
| Sunday, November 7th | 7:20 PM | Tennessee Titans vs Los Angeles Rams |
| Monday, November 8th | 7:15 PM | Chicago Bears vs Pittsburgh Steelers |
| Date | Time ( ET) | NFL Matchup |
| Thursday, November 11th | 6:20 PM | Baltimore Ravens vs Miami Dolphins |
| Sunday, November 14th | 12:00 PM | Buffalo Bills vs New York Jets |
| Sunday, November 14th | 12:00 PM | Tampa Bay Buccaneers vs Washington Football Team |
| Sunday, November 14th | 12:00 PM | Atlanta Falcons vs Dallas Cowboys |
| Sunday, November 14th | 12:00 PM | New Orleans Saints vs Tennessee Titans |
| Sunday, November 14th | 12:00 PM | Jacksonville Jaguars vs Indianapolis Colts |
| Sunday, November 14th | 12:00 PM | Detroit Lions vs Pittsburgh Steelers |
| Sunday, November 14th | 12:00 PM | Cleveland Browns vs New England Patriots |
| Sunday, November 14th | 3:05 PM | Minnesota Vikings vs Los Angeles Chargers |
| Sunday, November 14th | 3:05 PM | Carolina Panthers vs Arizona Cardinals |
| Sunday, November 14th | 3:25 PM | Philadelphia Eagles vs Denver Broncos |
| Sunday, November 14th | 3:25 PM | Seattle Seahawks vs Green Bay Packers |
| Sunday, November 14th | 7:20 PM | Kansas City Chiefs vs Las Vegas Raiders |
| Monday, November 8th | 7:15 PM | Los Angeles Rams vs San Francisco 49ers |
| Date | Time ( ET) | NFL Matchup |
| Thursday, November 18th | 7:20 PM | New England Patriots vs Atlanta Falcons |
| Sunday, November 21st | 12:00 PM | New Orleans Saints vs Philadelphia Eagles |
| Sunday, November 21st | 12:00 PM | Miami Dolphins vs New York Jets |
| Sunday, November 21st | 12:00 PM | Washington Football Team vs Carolina Panthers |
| Sunday, November 21st | 12:00 PM | Indianapolis Colts vs Buffalo Bills |
| Sunday, November 21st | 12:00 PM | Detroit Lions vs Cleveland Browns |
| Sunday, November 21st | 12:00 PM | San Francisco 49ers vs Jacksonville Jaguars |
| Sunday, November 21st | 12:00 PM | Houston Texans vs Tennessee Titans |
| Sunday, November 21st | 12:00 PM | Green Bay Packers vs Minnesota Vikings |
| Sunday, November 21st | 12:00 PM | Baltimore Ravens vs Chicago Bears |
| Sunday, November 21st | 3:05 PM | Cincinnati Bengals vs Las Vegas Raiders |
| Sunday, November 21st | 3:25 PM | Arizona Cardinals vs Seattle Seahawks |
| Sunday, November 21st | 3:25 PM | Dallas Cowboys vs Kansas City Chiefs |
| Sunday, November 21st | 7:20 PM | Pittsburgh Steelers vs Los Angeles Chargers |
| Monday, November 22nd | 7:15 PM | New York Giants vs Tampa Bay Buccaneers |
| Date | Time ( ET) | NFL Matchup |
| Thursday, November 25th | 11:30 AM | Chicago Bears vs Detroit Lions |
| Thursday, November 25th | 3:30 PM | Las Vegas Raiders vs Dallas Cowboys |
| Thursday, November 25th | 7:20 PM | Buffalo Bills vs New Orleans Saints |
| Sunday, November 28th | 12:00 PM | Tampa Bay Buccaneers vs Indianapolis Colts |
| Sunday, November 28th | 12:00 PM | New York Jets vs Houston Texans |
| Sunday, November 28th | 12:00 PM | Philadelphia Eagles vs New York Giants |
| Sunday, November 28th | 12:00 PM | Carolina Panthers vs Miami Dolphins |
| Sunday, November 28th | 12:00 PM | Tennessee Titans vs New England Patriots |
| Sunday, November 28th | 12:00 PM | Pittsburgh Steelers vs Cincinnati Bengals |
| Sunday, November 28th | 12:00 PM | Atlanta Falcons vs Jacksonville Jaguars |
| Sunday, November 28th | 3:05 PM | Los Angeles Chargers vs Denver Broncos |
| Sunday, November 28th | 3:25 PM | Los Angeles Rams vs Green Bay Packers |
| Sunday, November 28th | 3:25 PM | Minnesota Vikings vs San Francisco 49ers |
| Sunday, November 28th | 7:20 PM | Cleveland Browns vs Baltimore Ravens |
| Monday, November 29th | 7:15 PM | Seattle Seahawks vs Washington Football Team |
| Date | Time ( ET) | NFL Matchup |
| Thursday, December 2nd | 7:20 PM | Dallas Cowboys vs New Orleans Saints |
| Sunday, December 5th | 12:00 PM | New York Giants vs Miami Dolphins |
| Sunday, December 5th | 12:00 PM | Indianapolis Colts vs Houston Texans |
| Sunday, December 5th | 12:00 PM | Minnesota Vikings vs Detroit Lions |
| Sunday, December 5th | 12:00 PM | Philadelphia Eagles vs New York Jets |
| Sunday, December 5th | 12:00 PM | Denver Broncos vs Kansas City Chiefs |
| Sunday, December 5th | 12:00 PM | Arizona Cardinals vs Chicago Bears |
| Sunday, December 5th | 12:00 PM | Los Angeles Chargers vs Cincinnati Bengals |
| Sunday, December 5th | 12:00 PM | Tampa Bay Buccaneers vs Atlanta Falcons |
| Sunday, December 5th | 3:05 PM | Washington Football Team vs Las Vegas Raiders |
| Sunday, December 5th | 3:25 PM | Jacksonville Jaguars vs Los Angeles Rams |
| Sunday, December 5th | 3:25 PM | Baltimore Ravens vs Pittsburgh Steelers |
| Sunday, December 5th | 7:20 PM | San Francisco 49ers vs Seattle Seahawks |
| Monday, December 6th | 7:15 PM | New England Patriots vs Buffalo Bills |
| Date | Time ( ET) | NFL Matchup |
| Thursday, December 9th | 7:20 PM | Pittsburgh Steelers vs Minnesota Vikings |
| Sunday, December 12th | 12:00 PM | Dallas Cowboys vs Washington Football Team |
| Sunday, December 12th | 12:00 PM | San Francisco 49ers vs Cincinnati Bengals |
| Sunday, December 12th | 12:00 PM | Jacksonville Jaguars vs Tennessee Titans |
| Sunday, December 12th | 12:00 PM | Seattle Seahawks vs Houston Texans |
| Sunday, December 12th | 12:00 PM | Las Vegas Raiders vs Kansas City Chiefs |
| Sunday, December 12th | 12:00 PM | New Orleans Saints vs New York Jets |
| Sunday, December 12th | 12:00 PM | Atlanta Falcons vs Carolina Panthers |
| Sunday, December 12th | 12:00 PM | Baltimore Ravens vs Cleveland Browns |
| Sunday, December 12th | 3:05 PM | New York Giants vs Los Angeles Chargers |
| Sunday, December 12th | 3:25 PM | Detroit Lions vs Denver Broncos |
| Sunday, December 12th | 3:25 PM | Buffalo Bills vs Tampa Bay Buccaneers |
| Sunday, December 12th | 7:20 PM | Chicago Bears vs Green Bay Packers |
| Monday, December 13th | 7:15 PM | Los Angeles Rams vs Arizona Cardinals |
| Date | Time ( ET) | NFL Matchup |
| Thursday, December 16th | 7:20 PM | Kansas City Chiefs vs Los Angeles Chargers |
| Sunday, December 19th | 12:00 PM | Dallas Cowboys vs New Yorks Giants |
| Sunday, December 19th | 12:00 PM | Houston Texans vs Jacksonville Jaguars |
| Sunday, December 19th | 12:00 PM | Tennessee Titans vs Pittsburgh Steelers |
| Sunday, December 19th | 12:00 PM | Green Bay Packers vs Baltimore Ravens |
| Sunday, December 19th | 12:00 PM | Arizona Cardinals vs Detroit Lions |
| Sunday, December 19th | 3:05 PM | Cincinnati Bengals vs Denver Broncos |
| Sunday, December 19th | 3:05 PM | Atlanta Falcons vs San Francisco 49ers |
| Sunday, December 19th | 3:25 PM | Seattle Seahawks vs Los Angeles Rams |
| Sunday, December 19th | 7:20 PM | New Orleans Saints vs Tampa Bay Buccaneers |
| Monday, December 20th | 7:15 PM | Minnesota Vikings vs Chicago Bears |
| Date | Time ( ET) | NFL Matchup |
| Thursday, December 23rd | 7:20 PM | San Francisco 49ers vs Tennessee Titans |
| Saturday, December 25th | 3:30 PM | Cleveland Browns vs Green Bay Packers |
| Saturday, December 25th | 7:15 PM | Indianapolis Colts vs Arizona Cardinals |
| Sunday, December 19th | 12:00 PM | New York Giants vs Philadelphia Eagles |
| Sunday, December 19th | 12:00 PM | Los Angeles Rams vs Minnesota Vikings |
| Sunday, December 19th | 12:00 PM | Buffalo Bills vs New England Patriots |
| Sunday, December 19th | 12:00 PM | Tampa Bay Buccaneers vs Carolina Panthers |
| Sunday, December 19th | 12:00 PM | Jacksonville Jaguars vs New York Jets |
| Sunday, December 19th | 12:00 PM | Detroit Lions vs Atlanta Falcons |
| Sunday, December 19th | 12:00 PM | Los Angeles Chargers vs Houston Texans |
| Sunday, December 19th | 12:00 PM | Baltimore Ravens vs Cincinnati Bengals |
| Sunday, December 19th | 3:05 PM | Chicago Bears vs Seattle Sea |
| Sunday, December 19th | 3:25 PM | Pittsburgh Steelers vs Kansas City Chiefs |
| Sunday, December 19th | 3:25 PM | Denver Broncos vs Las Vegas Raiders |
| Sunday, December 19th | 7:20 PM | Washington Football Team vs Dallas Cowboys |
| Monday, December 20th | 7:15 PM | Miami Dolphins vs New Orleans Saints |
| Date | Time ( ET) | NFL Matchup |
| Sunday, January 2nd | 12:00 PM | Philadelphia Eagles vs Washington Football Team |
| Sunday, January 2nd | 12:00 PM | Carolina Panthers vs New Orleans Saints |
| Sunday, January 2nd | 12:00 PM | Tampa Bay Buccaneers vs New York Jets |
| Sunday, January 2nd | 12:00 PM | Miami Dolphins vs Tennessee Titans |
| Sunday, January 2nd | 12:00 PM | Jacksonville Jaguars vs New England Patriots |
| Sunday, January 2nd | 12:00 PM | Las Vegas Raiders vs Indianapolis Colts |
| Sunday, January 2nd | 12:00 PM | Kansas City Chiefs vs Cincinnati Bengals |
| Sunday, January 2nd | 12:00 PM | New York Giants vs Chicago Bears |
| Sunday, January 2nd | 12:00 PM | Atlanta Falcons vs Buffalo Bills |
| Sunday, January 2nd | 12:00 PM | Arizona Cardinals vs Dallas Cowboys |
| Sunday, January 2nd | 3:05 PM | Houston Texans vs San Francisco 49ers |
| Sunday, January 2nd | 3:05 PM | Denver Broncos vs Los Angeles Chargers |
| Sunday, January 2nd | 3:25 PM | Los Angeles Rams vs Baltimore Ravens |
| Sunday, January 2nd | 3:25 PM | Detroit Lions vs Seattle Seahawks |
| Sunday, January 2nd | 7:20 PM | Minnesota Vikings vs Green Bay Packers |
| Monday, January 3rd | 7:15 PM | Cleveland Browns vs Pittsburgh Steelers |
| Date | Time ( ET) | NFL Matchup |
| Sunday, January 9th | 12:00 PM | Dallas Cowboys vs Philadelphia Eagles |
| Sunday, January 9th | 12:00 PM | Green Bay Packers vs Detroit Lions |
| Sunday, January 9th | 12:00 PM | Indianapolis Colts vs Jacksonville Jaguars |
| Sunday, January 9th | 12:00 PM | Washington Football Team vs New York Giants |
| Sunday, January 9th | 12:00 PM | Chicago Bears vs Minnesota Vikings |
| Sunday, January 9th | 12:00 PM | Carolina Panthers vs Tampa Bay Buccaneers |
| Sunday, January 9th | 12:00 PM | New England Patriots vs Miami Dolphins |
| Sunday, January 9th | 12:00 PM | New Orleans Saints vs Atlanta Falcons |
| Sunday, January 9th | 12:00 PM | Tennessee Titans vs Houston Texans |
| Sunday, January 9th | 12:00 PM | Pittsburgh Steelers vs Baltimore Ravens |
| Sunday, January 9th | 12:00 PM | New York Jets vs Buffalo Bills |
| Sunday, January 9th | 12:00 PM | Cincinnati Bengals vs Cleveland Browns |
| Sunday, January 9th | 3:25 PM | Los Angeles Chargers vs Las Vegas Raiders |
| Sunday, January 9th | 3:25 PM | San Francisco 49ers vs Los Angeles Rams |
| Sunday, January 9th | 3:25 PM | Kansas City Chiefs vs Denver Broncos |
| Sunday, January 9th | 3:25 PM | Seattle Seahawks vs Arizona Cardinals |
