The hottest and coldest teams in the NFL face off on Sunday when the San Francisco 49ers host the Arizona Cardinals. While the Cardinals are losers of six straight games, the 49ers are on a nine-game winning streak heading into the playoffs despite being down to their third-string quarterback.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Cardinals vs 49ers. We’ve plenty of Vegas NFL odds and NFL week 18 picks for you to consider.
Cardinals vs 49ers Betting Lines
Cardinals Barely Competing
The Arizona Cardinals may be the worst team in the NFL right now as they enter Week 18 on a six-game losing streak. A lot of that loss was done when Kyler Murray was still healthy. Now that he’s on IR, the Cardinals‘ situation went from bad to truly awful.
Between David Blough, Trace McSorley and Colt McCoy, the backups for Arizona haven’t had a good performance among them.
Blough, at least, was decent in his first start last weekend with 222 yards and a touchdown. But he was sacked twice and finished 24 of 40, so he was not great. And it wasn’t enough to beat a bad Atlanta Falcons team.
Arizona is coming to back-to-back ATS wins, but they were against a bad Falcons team and an underperforming Bucs team. The 49ers are neither bad nor are they playing poorly.
Miracles happen, but don’t make the mistake of trusting the Cardinals to win at +1000.
49ers are NFL’s Hottest Team
The 49ers have clinched a spot in the playoffs, and their division, which could lead to a lack of motivation here. However, the 49ers can still claim the top seed in the NFC if the right pieces fall into place.
The first thing on their checklist has to be a win over the Cardinals at home in Week 18. A win and another Eagles loss would put San Francisco the No. 1 seed in the playoffs.
Brock Purdy continues to defy NFL odds and reason under center with 1,196 yards and 10 touchdowns over five starts. He does have back-to-back games with a pick, but in the end, it mattered little as the Niners kept winning.
There isn’t much to dig into here, really. The 49ers should manhandle the Cardinals and win by at least two touchdowns for the second time this season.
Cardinals vs 49ers Game Injuries
Cardinals vs 49ers Head-to-Head
The 49ers beat the Cardinals once already this season by 28 points in late November. The total went over the predicted number of 43 points.
Cardinals vs 49ers Game Information
- Game: Cardinals vs 49ers
- Date/Time: Sunday, Jan. 8, 4:25 PM ET
- Location: Levi’s Stadium, Santa Clara, CA
- How to watch Cardinals vs 49ers?: FOX
- Cardinals vs 49ers Live stream: NFL Game Pass
Cardinals vs 49ers Game Weather Conditions
56°, rainy & open-roof stadium
Cardinals vs 49ers Picks and Prediction
Predicted Score: 49ers 30, Cardinals 13
- Worth Betting on the Moneyline?
No. Barring some divine intervention, the Cardinals have no value in winning this game as such massive underdogs. Miracles happen, but we don’t suggest NFL betting on them.
- Worth Betting ATS?
Yes, because of the mismatch, the spread is the only way to bet a side in this game and still profit. Two touchdowns is a huge spread for an NFL game, but the 49ers already beat the Cardinals by almost 30 points earlier in the season. The Cardinals are arguably worse now and shouldn’t put up much fight.
- Worth Betting on the Totals?
Yes. With the 49ers’ offense humming and the Cardinals’ defensive struggles, we can see this game getting out of hand quickly. The over is 4-1 in the 49ers’ last five games, and I think the Cards’ defense is their next victim.
Bet On Cardinals vs 49ers
The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.