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Bills vs Lions Prediction, Game Preview, Live Stream, Odds & Picks

Buffalo Making Itself at Home in Detroit

The Detroit Bills, er, the Buffalo Bills kick off the NFL’s 2022 Thanksgiving tripleheader by welcoming back the Detroit Lions to Ford Field on the Thursday night football odds. The NFL betting lines strongly lean on Buffalo – by at least 10 points – as the Bills look to cover against a Lions team that has won three straight games.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Bills vs Lions. We’ve plenty of Vegas NFL odds and NFL week 12 picks for you to consider.

Bills vs Lions Odds, Game Preview, Live Stream, Picks & Predictions
Bills vs Lions Odds, Game Preview, Live Stream, Picks & Predictions

Bills vs Lions Betting Lines

Are the Bills ‘Back’?

It’s not how you start, it’s how you finish.” This was certainly the Bills’ motto this past Sunday against Cleveland as the team overcame a disastrous start to win and cover. Buffalo snapped a two-game skid on the moneyline and a three-game skid on the point spread.

More importantly, Josh Allen had one of his most efficient games even if he threw for just 197 yards and a touchdown. It was the first time in four games that Allen did not turn the ball over. Devin Singletary also stayed hot as he had another rushing touchdown.

But even with the offense’s resurgence, bettors should still be wary about betting online on the TNF odds. Buffalo had a hard time pressuring Browns quarterback Jacoby Brissett. The journeyman threw for 324 yards and three touchdowns. The Bills managed just one sack. And with pass rushers Greg Rousseau and A.J. Epensa dealing with ankle issues, Buffalo may have to deal with another prolific game from its opponent.

Don’t Play With Lions

True to their moniker, the Detroit Lions have been a dangerous team on the NFL betting lines. Detroit has won three straight games, all as underdogs. The team also improved to 16-9-0 against the spread (ATS) as an underdog since Dan Campbell took over as the coach.

The Lions also showcased a new wrinkle to the team: a sturdy defense. Detroit may still rank in the NFL in points against (28.2 per game), but this team beat Green Bay and the New York Giants by holding them to 18 points or fewer. And against Chicago, the Lions scored a pick-six in the fourth to fuel their comeback win.

Detroit has shown to be a resilient squad, which means it will have to overcome more injuries. Center Evan Brown (ankle) is questionable, as is receiver Josh Reynolds (back). But if the Lions can continue playing inspired defense to go with their offense, this team will be worth picking in NFL predictions.

Bills vs Lions Game Injuries

Bills vs Lions Head to Head

The Bills are 5-1 in their last six games against the Lions. However, the spread results have been even: 3-3 ATS for both. Allen has only faced the Lions once: a 14-13 win in his rookie year. Detroit covered the 2½-point spread there. The totals went under in all six of their games.

Bills vs Lions Game Information

  • Game: Bills vs Lions
  • Date: Thursday, Nov. 24, 2022
  • Time: 12:30 p.m. ET
  • Location: Ford Field, Detroit, Michigan (Domed Stadium)
  • Bills vs Lions Live Stream: NFL Game Pass

Take a Look at Other 2 Previews, Picks & Predictions For NFL Week 12 Matchups

Bills vs Lions Game Picks & Prediction

Predicted Score: Bills 31, Lions 27

  • Worth betting on the Moneyline?

On paper, this seems like a straightforward win for Buffalo. After all, the Lions are just 3-13-1 on the moneyline as an underdog, but that price is too long. Still, betting on Detroit, even at +330, is not ideal either. There is no value in a losing bet.

  • Worth Betting ATS?

This is where the juice is. The Lions have tremendous value on the spread. Detroit can work with nine points. The Lions are 4-2-0 ATS as an underdog of 10 or more points since 2021. Buffalo, on the flip side, is 5-3-2 ATS as a favorite of 10 or more points in this same span.

  • Worth betting on the Totals?

At 53½ points, the sportsbook has this as the highest total for the week. Four of the Lions’ five home games have gone over the total. But none of the Bills’ five road games have. This game could go bonkers as Detroit allows over 30 points at home on average.

  • Tempting Props?

This game could be a shootout. So to add to the total going over, make a prop bet on the fourth quarter to be the highest scoring at +210. The Lions lead the NFL with an average of 10 points per fourth quarter at home. They could pile on points when the Bills take their foot off the gas.

Be sure to check all the Thursday night football tonight odds for the Bills vs Lions.

“The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.”

Bills vs Lions Edge

Bills vs Lions Results

Bills vs Lions Game Summary

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