Teams who may cross paths at some point in the postseason square off in the preseason for the first time since 2019.
Buffalo used its first draft pick on a defensive player for the fourth year in a row so this could be the first chance to see former Florida cornerback Kaiir Elam in action.
The Colts went a different way. The first-round pick was traded when Indianapolis acquired quarterback Carson Wentz last season. The first three selections by Indianapolis all came on offense. Receiver Alec Pierce was picked in the second round while tight end Jelani Woods and offensive lineman Bernhard Raimann went in the third round.
According to the NFL betting lines, both teams are favored to win division titles. The Bills are at -225 in the odds to win the AFC East title. The Colts (-135) are favored in the AFC South.
The Bills (+650) have the best odds to win the Super Bowl while the Colts (+2500) are tied for 12th.
Teams don’t get much more mediocre than the 2021 Indianapolis Colts who finished 16th in the NFL in both total offense and total defense.
As is the case with most preseason affairs, it will be worth monitoring the quarterback breakdown with second-year QB Sam Ehlinger and rookie Jack Coan likely fighting it out for the No. 3 spot behind Matt Ryan and Nick Foles.
Ten of the 11 receivers currently on the roster are 25 or younger. The lone exception is 26-year-old Isaiah Ford. There is some youth at tight end as well.
There are 20 players from the defense who are either rookies or going into their second season so this is the next step in figuring out which of those players will be part of the defense moving forward.
Quarterback Matt Ryan is expected to play a quarter, which is a little unusual for somebody as experienced as he is. Getting some work in preseason games is the next step in Ryan getting acclimated to playing for a new team.
The Buffalo Bills didn’t need to change much as they were already a top Super Bowl contender. There are nine rookie defensive players looking to make a squad that led the NFL in total defense during the 2021 season.
Elam leads the list of young players to keep an eye on. Perhaps the most intriguing position could be the defensive line. Buffalo used two first-round selections and a pair of second-rounders to pick Gregory Rousseau, Ed Oliver, Carlos Basham, and A.J. Epenesa in the 2020 and 2021 drafts. This is the time when they can carve out key roles.
The running back situation is also intriguing with second-round pick James Cook being added to an already crowded backfield.
Colts vs Bills Injury Report
Linebacker Shaquille Leonard (back) is recovering from back surgery and it is uncertain when one of the NFL’s top defensive players will return. Receiver Mike Strachan is questionable for the regular-season opener while offensive lineman Carter O’Donnell is out indefinitely for the Colts. Receiver Parris Campbell is questionable for this game due to a hamstring issue. He did some 7-on-7 work in Wednesday’s practice. Offensive tackle Dennis Kelly is also questionable.
For the Bills, defensive lineman Eli Ankjou (calf), defensive backs Jordan Poyer (elbow) and Tre’Davious White (knee), offensive lineman Ike Boettger (Achilles) and receiver Marquez Stevenson (foot) are all questionable for the start of the regular season.
Colts vs Bills Head-to-Head
Buffalo has won five of the last six preseason meetings with the Colts and that includes a 24-16 win in 2019. The last two matchups have been decided by a total of nine points while each of the last four preseason contests between the teams has finished over the total.
The teams met in the playoffs following the 2020 season with Buffalo winning 27-24. After Indianapolis won six consecutive regular-season games in the series, Buffalo has won four of the last seven meetings in either the regular season or the playoffs.
Excluding the preseason games, five of the last nine matchups between the teams have finished as one-score games.
Colts vs Bills Game Information
- Game: Indianapolis Colts vs Buffalo Bills
- Location: Highmark Stadium, Orchard Park, N.Y.
- Day/Time: Saturday, 4:00 p.m. ET
- Live stream: NFL Game Pass
Colts vs Bills Betting Lines
|Team||Point Spread||Moneyline||Total||Team Total|
|Indianapolis Colts||-1½ -115||-120||35-110o|
Colts vs Bills Predictions
Buffalo has won its last eight preseason games and has covered in each of those contests. Six of the last eight Buffalo preseason contests have finished over the total. Buffalo’s last preseason loss came against Cincinnati on Aug. 26, 2018.
The Colts have won their last four preseason affairs and gone 3-0-1 against the NFL betting lines. Something of interest, 12 of the last 13 Indianapolis preseason games were one-score finals before a 27-17 win over Detroit in the 2021 preseason finale.
With a 35-point total, eight of the Colts’ last nine games played in the preseason have had totals in the 30s.
Who are we to go against a team on an eight-game winning streak in the preseason?
Colts vs Bills Trends
Colts vs Bills Edge
Colts vs Bills Results
Colts vs Bills Game Injuries
Colts vs Bills Game Box Score