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Colts vs Titans Prediction, Preview, Stream, Odds & Picks

Crucial AFC South Clash

In Week 7, the Indianapolis Colts pay a visit to the Tennessee Titans in an important divisional game. Indianapolis (+115) and Tennessee (+160) are the clear favorites to win the AFC South. Sunday’s matchup could decide who reigns supreme, as the Titans took down the Colts in Week 4 with a 24-17 win.

Colts vs Titans Prediction, Preview, Stream, Odds & Picks
Colts vs Titans Prediction, Preview, Stream, Odds & Picks

At 1-2-1 in the AFC South, Indianapolis is in a must-win situation. The Titans (3-2) are led by a strong defense, while the Colts (3-2-1) come off their best scoring performance of the season.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Colts vs Titans. We’ve plenty of Vegas NFL odds for you to consider.

Colts Come Alive

After a 1-2-1 start that included poor performances against the Houston Texans (20-20) and Jacksonville Jaguars (24-0 loss), the Indianapolis Colts have found their footing. They come off back-to-back wins against the Denver Broncos (12-9) and Jaguars (34-27). In Week 6, Indianapolis’ offense had its best game.

After running back Jonathan Taylor’s All-Pro 2021 season, many expected the Colts to be a run-first offense. However, with the offensive lines’ struggles and the acquisition of quarterback Matt Ryan, Indy has opted for a pass-heavy scheme.

In the first three weeks, the offense was unproductive due to Ryan’s inconsistencies. Recently, Ryan has turned the corner. In Week 4, he had a nice game against the Titans, posting 356 passing yards with two touchdowns. Last week was his best performance yet, totaling 389 passing yards and three touchdowns with a 72.4 completion percentage. With the passing game’s success, the Colts could move into the driver’s seat in the AFC South.

Due to injuries, Indianapolis’ run game got even worse over the last two games. Superstar tailback Taylor and Nyheim Hines, who gets plenty of snaps as a second-string, sat out last game but could both return against the Titans. The Colts need to get the run game going after Ryan attempted 58 passes in Week 6, which is not sustainable for a 37-year-old quarterback.

Titans Coming off Bye

After a two-game road trip, the Tennessee Titans are back home in their soon-to-be-replaced stadium. During the bye week, Tennessee announced plans to build a new $2.1 billion domed stadium. For now, the Titans will have to contain their excitement since the ambitious project will take years to build. Nissan Stadium will be roaring in this key divisional matchup.

Since an embarrassing 41-7 loss to the Buffalo Bills in primetime, the Titans have quietly ripped off a three-game winning streak. Tennessee is playing its style of football: Good defense and a bruising run game. Running back Derrick Henry comes off back-to-back games with over 100 rushing yards. Plus, quarterback Ryan Tannehill is playing better, hitting throws off play-action.

The defense ranks 28th in allowed yards per game, but it’s holding strong inside the 20 (ninth in allowed touchdown percentage in the red zone). So far, Tennessee’s bend-but-don’t-break style is working. During the winning streak, opponents are scoring under 20 points per game. Led by defensive tackle Jeffery Simmons and edge rushers Denico Autry and Rashad Weaver, the Titans’ defensive line is playing at a high level.

Colts vs Titans Game Injuries

Colts vs Titans Head-to-Head

The Titans have dominated this rivalry since 2020, winning four of five games. The Colts lost to Tennessee 24-17 in Week 4, making this a must-win to stay alive in the AFC South race.

Colts vs Titans Game Information

  • Date: Sunday, Oct. 23
  • Time: 1 p.m. ET
  • Location: Nissan Stadium, Nashville, TN
  • How to watch Colts vs Titans? ESPN
    Colts vs Titans Live stream: NFL Game Pass

Colts vs Titans Betting Lines

Colts vs Titans Prediction

This matchup will come down to the red zone. The Colts will be able to move the ball, but their offense ranks 25th in touchdown-scoring percentage when in the red zone. The Titans’ defense will come through once again. Moreover, Indianapolis is allowing an average of 121 rushing yards (21st), and All-Pro linebacker Shaquille Leonard has yet to play a full game. Tennessee leads the NFL in red zone offense, which spells trouble for the Colts’ poor red zone defense (24th). The Titans will stay hot, winning their fourth straight game.

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Colts vs Titans Edge

Colts vs Titans Results

Colts vs Titans Game Summary


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