- Herbert Injury Crucial
- Jacksonville Jaguars
- Los Angeles Chargers
- Jaguars vs Chargers Head-to-Head
- Jaguars vs Chargers Game Injuries
- Jaguars vs Chargers Game Information
- Jaguars vs Chargers Betting Lines
- Jaguars vs Chargers Prediction
- Jaguars vs Chargers Trends
- Jaguars vs Chargers Edge
- Jaguars vs Chargers Results
- Jaguars vs Chargers Game Summary
Jaguars vs Chargers Prediction, Game Preview, Live Stream, Odds & Picks
Herbert Injury Crucial
The Jacksonville Jaguars could be the biggest surprise in the AFC this season. They’re 1-1 and are looking like a solid turnaround story.
Week 3 will be their toughest test to date, though, as they head to Los Angeles to face the Chargers – a team who is among the favorites to win the Super Bowl, according to the NFL betting odds.

The Chargers are coming off a three-point loss to the Kansas City Chiefs on Sept. 15 in a game they probably should have won. They’re favored on the NFL odds as the oddsmakers expect a rebound since they’ve had 10 days to prepare.
The biggest question mark in the game is the status of Chargers quarterback Justin Herbert, who is dealing with an injury to his ribs.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Jaguars vs Chargers. We’ve plenty of Vegas NFL odds for you to consider.
Jacksonville Jaguars
The Jacksonville Jaguars might be the biggest riser in terms of AFC stock value over the first two weeks of the season. The Philadelphia Eagles are the NFC riser, but the Jags are one of the AFC teams that has boosted its stock the most.
Jacksonville shut out the Indianapolis Colts in Week 2, cruising to an easy 24-0 win. With a better defensive effort in Week 1, they’d easily be 2-0.
Quarterback Trevor Lawrence had a nightmarish rookie season under former coach Urban Meyer.
Now that Super Bowl-winning coach Doug Pederson (with the Philadelphia Eagles) is Jacksonville’s head coach, Lawrence has a competent guide in the early stages of his NFL career.
He looks like a very different and much-improved player. The Jaguars look better and, meanwhile, the rest of the AFC South looks a lot worse.
Both Indianapolis and the Tennessee Titans are winless through two games. Jacksonville has a real chance to win the division and it already has a head-to-head win against the Colts.
Lawrence was a solid 25 of 30 last week with no turnovers and it will take a similar effort this week to hang with the Chargers.
Los Angeles Chargers
Los Angeles Chargers have to balance their short-term goals with their long-term interests in this game. The Jaguars are improved, but they are not an elite team.
Herbert got banged up against the Chiefs on Thursday Night Football. Getting the win here is key, but getting Herbert healthy is more important to their season-long prospects.
Could this be the time they rely on the ground game more? The Chargers are averaging a league-worst 2.7 yards per carry. They’re one of 11 teams that’s yet to notch a rushing touchdown.
Those who bet online know they have a lethal passing game, but finding some balance on the ground could be key this week considering Herbert’s health.
Jaguars vs Chargers Head-to-Head
The teams last met in 2020. The Chargers won 39-29.
Jaguars vs Chargers Game Injuries
Jaguars vs Chargers Game Information
- Date: Sunday, Sept. 25, 2022
- Time: 4:05 p.m. ET
- Location: SoFi Stadium, Los Angeles
- How to watch Jaguars vs Chargers? ESPN
Jaguars vs Chargers Live stream: NFL Game Pass
Jaguars vs Chargers Betting Lines
Jaguars vs Chargers Prediction
The Chargers’ decision on their quarterback looms large in this game. Given that the Jaguars are getting a full touchdown in the sportsbook, it makes more sense to take the Jags.
It will make even more sense if that point spread rises to 7½ or eight points. However, the best thing to do is wait to see how healthy Herbert is and how the Chargers approach this situation.
“The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.”