BETUS
Cash: $ FP: $ My Account Deposit Login Join Logout
  • Sportsbook
  • Live Betting
  • Casino
  • Racebook
  • Promotions
  • BetUS TV
  • More
  • Contests
  • Loyalty
  • Locker Room
  • Crypto Help
THE LOCKER ROOM SPORTS BETTING NEWS, STATS, ODDS & FREE PICKS
BetUS Advertisement BetUS Advertisement
  • MLB
    • NEWS
    • PICKS
    • ODDS
    • WORLD SERIES
    • TEAMS
  • NFL
    • NEWS
    • PICKS
    • MATCHUPS
      • NFL WEEK 1
      • NFL WEEK 2
      • NFL WEEK 3
      • NFL WEEK 4
      • NFL WEEK 5
      • NFL WEEK 6
      • NFL WEEK 7
      • NFL WEEK 8
      • NFL WEEK 9
      • NFL WEEK 10
      • NFL WEEK 11
      • NFL WEEK 12
      • NFL WEEK 13
      • NFL WEEK 14
      • NFL WEEK 15
      • NFL WEEK 16
      • NFL WEEK 17
      • NFL WEEK 18
      • Bengals vs Rams Super Bowl LVI
      • CHAMPIONSHIP GAMES
      • DIVISIONAL
      • WILD CARD
    • NFL Rumors
    • NFL Mock Draft
    • TEAMS
    • THE NFL SHOW
    • INJURIES
    • MONDAY NIGHT GAME
  • NCAAF
    • NEWS
    • THE NCAAF SHOW
    • PICKS
    • ODDS
    • BOWL GAMES
  • NBA
    • PICKS
    • NEWS
    • THE NBA SHOW
    • ODDS
    • TEAMS
  • NCAAB
    • NEWS
    • PICKS
    • MARCH MADNESS: PICKS & PREDICTIONS
    • MARCH MADNESS ODDS
    • The NCAAB Show
  • Soccer
    • NEWS
    • PICKS
    • ODDS
    • FIFA World Cup
    • THE PREMIER LEAGUE SHOW
    • The Serie A Show
    • The Bundesliga Show
    • La Liga Show
    • The Champions League Show
    • The Europa League show
  • NHL
    • NEWS
    • PICKS
    • ODDS
    • Teams
  • TENNIS
  • HORSE RACING
    • NEWS
    • PICKS
    • ODDS
  • UFC & MMA
    • NEWS
    • PICKS
    • ODDS
  • Esports
    • ESPORTS NEWS
    • ESPORTS PICKS
    • ODDS
  • More
    • Boxing
      • NEWS
      • PICKS
      • ODDS
    • Golf
    • Motorsports
    • NASCAR
    • Rugby News & Picks
    • Cricket
    • WNBA
    • More Sports
    • How to bet on sports
    • OLYMPIC GAMES
    • Entertainment
No Result
View All Result
NFL
NEWS PICKS MATCHUPS NFL RUMORS MOCK DRAFT NFL TEAMS THE NFL SHOW INJURIES MONDAY NIGHT GAME
BETUS
Cash: $ FP: $ My Account Deposit Login Join Logout
  • MLB
    • NEWS
    • PICKS
    • ODDS
    • WORLD SERIES
    • TEAMS
  • NFL
    • NEWS
    • PICKS
    • MATCHUPS
      • NFL WEEK 1
      • NFL WEEK 2
      • NFL WEEK 3
      • NFL WEEK 4
      • NFL WEEK 5
      • NFL WEEK 6
      • NFL WEEK 7
      • NFL WEEK 8
      • NFL WEEK 9
      • NFL WEEK 10
      • NFL WEEK 11
      • NFL WEEK 12
      • NFL WEEK 13
      • NFL WEEK 14
      • NFL WEEK 15
      • NFL WEEK 16
      • NFL WEEK 17
      • NFL WEEK 18
      • Bengals vs Rams Super Bowl LVI
      • CHAMPIONSHIP GAMES
      • DIVISIONAL
      • WILD CARD
    • NFL Rumors
    • NFL Mock Draft
    • TEAMS
    • THE NFL SHOW
    • INJURIES
    • MONDAY NIGHT GAME
  • NCAAF
    • NEWS
    • THE NCAAF SHOW
    • PICKS
    • ODDS
    • BOWL GAMES
  • NBA
    • PICKS
    • NEWS
    • THE NBA SHOW
    • ODDS
    • TEAMS
  • NCAAB
    • NEWS
    • PICKS
    • MARCH MADNESS: PICKS & PREDICTIONS
    • MARCH MADNESS ODDS
    • The NCAAB Show
  • Soccer
    • NEWS
    • PICKS
    • ODDS
    • FIFA World Cup
    • THE PREMIER LEAGUE SHOW
    • The Serie A Show
    • The Bundesliga Show
    • La Liga Show
    • The Champions League Show
    • The Europa League show
  • NHL
    • NEWS
    • PICKS
    • ODDS
    • Teams
  • TENNIS
  • HORSE RACING
    • NEWS
    • PICKS
    • ODDS
  • UFC & MMA
    • NEWS
    • PICKS
    • ODDS
  • Esports
    • ESPORTS NEWS
    • ESPORTS PICKS
    • ODDS
  • More
    • Boxing
      • NEWS
      • PICKS
      • ODDS
    • Golf
    • Motorsports
    • NASCAR
    • Rugby News & Picks
    • Cricket
    • WNBA
    • More Sports
    • How to bet on sports
    • OLYMPIC GAMES
    • Entertainment
No Result
View All Result
Sports betting at America's Sportsbook - BetUS
Cash: $   FP: $ Login Join
NFL
NEWS PICKS MATCHUPS NFL RUMORS MOCK DRAFT NFL TEAMS THE NFL SHOW INJURIES MONDAY NIGHT GAME
  • UFC & MMA Betting
  • NHL
  • Horse Racing
  • Tennis
  • Golf
  • Boxing
  • Motorsports
  • NASCAR
  • Cricket
  • Esports Betting Analysis, Picks & Predictions

Home » Bet On NFL Games 2022 » NFL Matchups » Chiefs vs 49ers Prediction, Preview, Stream, Odds & Picks

Chiefs vs 49ers Prediction, Preview, Stream, Odds & Picks

Riley Thomas
Oct 21, 2022, 6:30am ET
in NFL Matchups
Chiefs vs 49ers Odds, Game Preview, Live Stream, Picks & Predictions

Chiefs vs 49ers Odds, Game Preview, Live Stream, Picks & Predictions

BetUS Advertisement BetUS Advertisement

Heavyweights Collide

Two playoff contenders will clash on Sunday when the San Francisco 49ers play host to the Kansas City Chiefs. According to NFL odds, Kansas City is the third choice (+750) to win the Super Bowl while San Francisco is the fourth (+1400). Both teams appeared in their respective conference championship games last season, falling just short of a Super Bowl appearance. Through six games, the Chiefs (4-2) and 49ers (3-3) look the part once again.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Chiefs vs 49ers. We’ve plenty of Vegas NFL odds for you to consider.

Chiefs Need Balance

As long as quarterback Patrick Mahomes and coach Andy Reid are in town, the Kansas City Chiefs will remain contenders. The offense is rolling, averaging 29.8 points (first) and 382.3 yards per game (fifth). While the Chiefs are one of three top-tier teams in the NFL, some concerns have come to light.

The run game has been inconsistent, creating an imbalance. In last week’s 24-20 loss to the Buffalo Bills, Kansas City averaged only 3.8 yards per carry. The unit had 40 pass attempts compared to 18 rushes in Week 6, and 43 passes versus 23 run attempts in Week 5. Early in the season, it looked like Kansas City would utilize the run more often, so much for that. Without a doubt, the Chiefs’ offense will be successful no matter what, but the run game becomes a key factor in the postseason.

As usual, Kansas City’s defense is the main concern. The secondary has played poorly, ranking 30th in opponent completion percentage. Injuries are part of the reason as cornerbacks Trent McDuffie and Rashad Fenton have been absent. Both could be back this week along with linebacker Willie Gay, who got off to a great start and returns after serving a four-game suspension.

Based on his Instagram video. I think #Chiefs linebacker Willie Gay is happy to be back. pic.twitter.com/vpq7Rr1Hiq

— Nick Jacobs (@Jacobs71) October 18, 2022

49ers Hope for Reinforcements

Despite numerous injuries, the San Francisco 49ers kept winning … until last week. Key absences finally caught up in Week 6 as the 49ers fell to the Atlanta Falcons 28-14. Two of the top players on the 49ers’ roster, left tackle Trent Williams and defensive end Nick Bosa, could return against the Chiefs. In addition, starting right tackle Mike McGlinchey and cornerback Charvarius Ward have a decent chance of playing. Unfortunately, injuries keep stacking up as starting safety Talanoa Hufanga, who was enjoying a breakout season, entered the concussion protocol.

Ultimately, returning Williams and/or Bosa will be vital. If the 49ers deploy another skeleton crew, defeating the Chiefs will be a near-impossible task.

San Francisco made a huge trade on Thursday night, acquiring running back Christian McCaffrey from the Carolina Panthers for a bunch of draft picks. It provides the 49ers with a true No. 1 running back, although it is unclear if McCaffrey will play on Sunday.

Regardless of McCaffrey’s role and the injuries, quarterback Jimmy Garoppolo must play better. He comes off perhaps his worst performance of the season with two interceptions and an 87 passer rating. Against Kansas City, the 49ers will have to make plays through the air. The Chiefs’ run defense is stingy, allowing only 90.5 rushing yards per game (fourth).

Chiefs vs 49ers Game Injuries

Chiefs vs 49ers Head-to-Head

Since coach Kyle Shanahan was hired in 2017, the 49ers have yet to beat the Chiefs. Kansas City’s Reid is 2-0 against Shanahan, including the 31-20 win in Super Bowl LIV.

Chiefs vs 49ers Game Information

  • Date: Sunday, Oct. 23
  • Time: 4:25 p.m. ET
  • Location: Levi’s Stadium, Santa Clara, CA
  • How to watch Chiefs vs 49ers? ESPN
    Chiefs vs 49ers Live stream: NFL Game Pass

Top 5 Highest-Paid NFL Players in the 2022-2023 Pro Football Season

Top 5 Highest-Paid NFL Players in the 2022-2023 Pro Football Season

By E. Z. Ryder  /  March 28, 2023
The NFL used to be a bastion of fake contracts with players signing five-year deals only to see them getting...
Read More
Lamar Officially Wants Out of Baltimore; What’s Next For Jackson?

Lamar Officially Wants Out of Baltimore; What’s Next For Jackson?

By Daniel Saenz  /  March 27, 2023
How do you like to start your Monday mornings? For me, I work out at 6 a.m., get back home,...
Read More
2023 NFL Draft – Carolina Dreaming

2023 NFL Draft – Carolina Dreaming

By Nikki Adams  /  March 26, 2023
Will the Carolina Panthers trade out of the No. 1 pick after giving up a ransom to the Chicago Bears...
Read More
Free Agency Moves – NFC West

Free Agency Moves – NFC West

By Nikki Adams  /  March 25, 2023
The San Francisco 49ers headline the NFC West as the team to beat. The Los Angeles Rams enter as the...
Read More
Free Agency Moves – AFC West

Free Agency Moves – AFC West

By Nikki Adams  /  March 24, 2023
The Kansas City Chiefs have won seven straight AFC West championships since 2016 under head coach Andy Reid along with...
Read More
Free Agency Moves – NFC South

Free Agency Moves – NFC South

By Nikki Adams  /  March 24, 2023
No division is set for a bigger top-to-bottom overhaul than the NFC South – from the head coach and staff...
Read More
NFL Free Agency Moves – AFC South

NFL Free Agency Moves – AFC South

By Nikki Adams  /  March 24, 2023
The Jacksonville Jaguars look to build on an impressive first season under head coach Doug Pederson, in which they turned...
Read More
Free Agency Moves – AFC North

Free Agency Moves – AFC North

By Nikki Adams  /  March 23, 2023
The Cincinnati Bengals are the standard of the AFC North and enter the NFL betting markets for the upcoming season...
Read More
Free Agency Moves – NFC North

Free Agency Moves – NFC North

By Nikki Adams  /  March 22, 2023
Don’t look now, but the Detroit Lions are favored to win the NFC North! The feat, if accomplished, would be...
Read More
All right Jaguars, You Got the Floor! Now Don’t Screw it Up

All right Jaguars, You Got the Floor! Now Don’t Screw it Up

By Daniel Saenz  /  March 22, 2023
What’s one thing the Jacksonville Jaguars have going for themselves in the AFC South that all other teams in the...
Read More

Chiefs vs 49ers Betting Lines

Parlay & Odds Calculator

Chiefs vs 49ers Prediction

This will be the 49ers’ first shot at redemption after losing Super Bowl LIV to the Chiefs. Like the last matchup, San Francisco does not have enough to come out on top, especially with an injury-riddled roster. Kansas City’s secondary has been a big weakness, but is Garoppolo good enough to carry San Francisco? Probably not. Moreover, the Atlanta Falcons ran for 168 yards against the 49ers in Week 6, giving Kansas City the opportunity to establish the run. Ultimately, Mahomes and the Chiefs’ offense will be too much.

BET THIS PICK: Kansas City Chiefs (-2)

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Chiefs vs 49ers Trends

Chiefs vs 49ers Edge

Chiefs vs 49ers Results

Chiefs vs 49ers Game Summary

  • Buccaneers vs Panthers Prediction, Game Preview, Live Stream, Odds & Picks
  • Seahawks vs Chargers Odds, Game Preview, Live Stream, Picks & Predictions

Tags: Kansas City ChiefsNFLNFL-Week-7San Francisco 49ers
Riley Thomas

Riley Thomas

Riley Thomas grew up an avid sports fan and decided to put his passion to paper. He is a young, up-and-coming writer with experience covering various sports and sports betting. Whether it's heavy analytical pieces or fun and engaging pieces, Riley has you covered. He always completes extensive research on every piece to ensure you will receive the best content. Riley is a 2021 graduate of Ohio University and cannot wait for what's ahead in his career covering sports!

Next Post
Lions vs Cowboys Odds, Game Preview, Live Stream, Picks & Predictions

Lions vs Cowboys Prediction, Game Preview, Live Stream, Odds and Picks

BetUS Advertisement

NBA Picks, Predictions & Betting Odds

NFL Season Betting Strategy | Fail to Plan, Plan to Fail

Stay Connected

Recommended

Barcelona's Ivorian midfielder Franck Kessie celebrates after scoring his team's second goal during the Spanish league football match between FC Barcelona and Real Madrid CF

Elche vs Barcelona Prediction, Match Preview, Live Stream, Odds and Picks

March 29, 2023
Reece James reacts after the UEFA Champions League - Ina fassbender / afp

Chelsea vs Aston Villa Prediction, Match Preview, Live Stream, Odds and Picks

March 29, 2023
Sevilla's players observe a minute of silence for the victims of the earthquake in eastern Turkey during the UEFA Europa League last 16 second leg football match between Fenerbahce SK and Sevilla FC

Cadiz vs Sevilla Prediction, Match Preview, Live Stream, Odds and Picks

March 29, 2023
Inter Milan's Argentinian forward Lautaro Martinez goes for the ball during the Italian Serie A football match between Inter and Lecce

Inter Milan vs Fiorentina Prediction, Match Preview, Live Stream, Odds and Picks

March 29, 2023
BetUS Advertisement
Sports Betting

SPORTSBOOK

  • Online Sportsbook
  • NFL Odds
  • NBA Odds
  • MLB Odds
  • World Series Odds
  • NHL Odds
  • NCAAF Odds
  • NCAAB Odds
  • UEFA Champions League Odds
  • Nascar Odds
  • OIympic Games Odds
  • French Open Odds
  • Live Betting

CASINO

  • Online Casino Games
  • Tournaments
  • Bonus Play
  • Play Blackjack
  • Online Slots
  • Casino Guide
  • How to Play Blackjack

HORSE RACING

  • Racebook
  • Horse Racing Odds
  • Horse Racing Rules
  • Racebook Glossary
  • Horse Race Betting
  • Pegasus World Cup
  • Triple Crown Betting
  • Horse Racing News

INFORMATION

  • Sports Betting News
  • BetUS Sportsbook Reviews
  • How to Bet Online
  • How to Bet On Sports
  • About Us
  • Rules & Regulations
  • Help & FAQ
  • Press Room
  • Sporting Events Odds
  • Affiliates

BETTING OFFERS

  • Casino Promotions
  • Bonuses
  • Contests
  • Sign Up Bonus
  • Crypto Bonus
  • Casino Bonus
  • Refer a Friend

OTHER

Why Join?
Contact Us
1 (888) 512-3887
Email
BetUS Privacy Policy
Terms & Conditions
IF YOU HAVE A GAMBLING PROBLEM, CALL 1-800-GAMBLER
license certificate

© 1994 - 2023 BetUS.. All Rights Reserved The BetUS Brand and Logo are trademarks of BetUS. BetUS is a premier online sportsbook and gambling destination. BetUS is a fully licensed sportsbook providing a reliable and secure sports betting service to millions of satisfied online betting customers world wide since 1994. BetUS offers football betting, live and NFL odds all season long.

Why Join? My Account
Sportsbook
Live Betting
Racebook
Promotions
Casino
Contests
Locker Room
BETUS TV
Loyalty
Crypto Help
Chat
  • Help
  • About Us
  • Privacy Policy
  • Rules & Regulations
  • Terms & Conditions
  • Logout