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Chargers vs Cardinals Prediction, Game Preview, Live Stream, Odds & Picks

Injury-Ravaged Squads Meet in Glendale

The Los Angeles Chargers visit the Arizona Cardinals as slight favorites. Both squads have been hit with injuries and most notably, star quarterback Kyler Murray may not play for the Cardinals. The team has gone 1-1 without him as Colt McCoy prepares to start again. The Chargers are 5-5 but have consistently won as favorites and has covered five straight games in Arizona per the NFL betting odds.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Chargers vs Cardinals. We’ve plenty of Vegas NFL odds and NFL week 12 picks for you to consider.

Chargers vs Cardinals Odds, Game Preview, Live Stream, Picks & Predictions
Chargers vs Cardinals Odds, Game Preview, Live Stream, Picks & Predictions

Chargers vs Cardinals Betting Lines

Chargers Remain a Reliable Favorite

This season has proven disappointing for the Chargers. All that preseason hype has amounted to little. However, the team is 7-3 as an NFL pick against the spread (ATS) and that’s tied for the second-best cover rate. Furthermore, the Chargers are 3-0 ATS as a favorite on the road.

Justin Herbert and the offense has regressed. This unit is 14th in scoring (22.7 points) versus finishing fifth in 2021 (27.9). Injuries are partly to blame as Herbert’s top target, Mike Williams (ankle) is hurt along with key members of the offensive line.

The defense, which is missing its star players, has stayed as one of the three worst teams in scoring (25.8). This team may not make the playoffs, but it has found ways to deliver on the online sports betting lines.

Hurt Cardinals Continue To Lean on McCoy

After beating the Rams two weeks ago, the Cardinals came back to Earth and got humbled by the 49ers in Mexico. McCoy, who started in place of Murray, did what he could but he and the offense managed just 10 points while turning the ball over twice.

The Cardinals are facing a less-prolific defense in the Chargers, but it’s still an uphill climb for the battered team. Arizona is not only missing Murray but the likes of receiver Rondale Moore (groin) and blindside protector D.J. Humphries (back) are banged up. On top of that, tight end and top pass catcher Zach Ertz (knee) is out for the year.

It doesn’t help that the Cardinals have the second-worst scoring defense (26.9). Should the team get lit up early, it may have a tough time mounting a comeback.

Chargers vs Cardinals Game Injuries

Chargers vs Cardinals Head to Head

The Chargers have won four of their last five games against the Cardinals. Arizona last beat the Chargers at home in 2014 but it was the visitor that covered. The total has gone over in three of their last four games.

Chargers vs Cardinals Game Information

  • Game: Chargers vs Cardinals
  • Date: Sunday, Nov. 27, 2022
  • Time: 4:05 p.m. ET
  • Location: State Farm Stadium, Glendale, Arizona
  • How to watch Chargers vs Cardinals? CBS
    Chargers vs Cardinals Live Stream: NFL Game Pass

Take a Look at Other 2 Previews, Picks & Predictions For NFL Sunday Night Football Matchups

Chargers vs Cardinals Game Weather Conditions

It will be fairly warm (70 degrees Fahrenheit) with light winds (six miles per hour) and no precipitation (zero percent).

Chargers vs Cardinals Game Picks & Prediction

Predicted Score: Chargers 29, Cardinals 23

  • Worth betting on the Moneyline? 

This is a solid line to bet online on the Chargers on the moneyline. At -220, Los Angeles should be able to beat Arizona as the offense is more talented and Arizona’s porous defense will put up little-to-no resistance.

  • Worth Betting ATS?

For a better value, lay the points on the Chargers. The team is only 6-7 ATS as a favorite of five or fewer points since last season. But Arizona does not have the firepower nor the defense to keep the Chargers down.

  • Worth betting on the Totals?

Four of the Cardinals’ six home games have gone over the total. The Cardinals have allowed visitors to score 31 or more points in four of these games. This is the invitation the Chargers need to light up the scoreboard so bet on the ‘over’ at 48 points.

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Chargers vs Cardinals Edge

Chargers vs Cardinals Results

Chargers vs Cardinals Game Summary

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