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Chargers vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks

The Los Angeles Chargers are coming off a win over the Atlanta Falcons, while the San Francisco 49ers are coming off a one-week break.

The 49ers had been battling all sorts of injuries, so getting time off to rest and rejuvenate could be crucial on the Sunday night football odds. Are they the best option versus the NFL betting odds in this spot?

Chargers vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks
Chargers vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Chargers vs 49ers. We’ve plenty of Vegas NFL odds and NFL week 10 picks for you to consider.

Los Angeles Chargers

The Chargers narrowly defeated the Atlanta Falcons last week, winning on a last-secon field goal, 20-17. In typical Chargers form, they played a tight, one-score game that went down to the wire.

They had fumbled the ball on their late-game drive in a 17-17 tie. The Falcons recovered, but the Atlanta linebacker who recovered the fumble then lost the ball before he was tackled.

The Chargers recovered and managed to take advantage of that remarkable gift. This team is now 5-3 and is driving toward the playoffs, but they clearly have some flaws.

They’re 28th in rushing and those who bet online know it’s tough to win on the road without a ground game. Can they solely rely on Herbert to go on the road to San Francisco and carry the load?

The good news is their offensive line has been strong. They’ve allowed the fewest sacks in the NFL. If they keep Nick Bosa and company away from Herbert, their chances improve a lot.

San Francisco 49ers

The 49ers still have a lot of players banged up and nowhere close to full health. However, they were able to defeat the Los Angeles Rams two weeks ago, 31-14.

Their defense looked great and Christian McCaffrey certainly played at the level the Niners need in order to make a run at the NFC championship and the Super Bowl.

He dominated the Rams and showed his trademark versatility, and with a full bye week to integrate, he should be much better.

Keep an eye on the 49er’s injury report before you make your NFL picks. Arik Armstead and Samson Ebukam missed practice this week while Dre Greenlaw, and Jason Verrett limited.

We know you love night games, and that’s why BetUS brings you the best SNF odds games.

Chargers vs 49ers Injury Report

Chargers vs 49ers Head-to-Head

These teams last met in 2018. The Chargers won, 29-27.

Chargers vs 49ers Game Information

  • Game: Chargers vs 49ers
  • Date: November 13, 2022
  • Time: 8:20 p.m. ET
  • Location: Levi’s Stadium
  • How to watch Chargers vs 49ers?
    Chargers vs 49ers Live stream: NFL Game Pass

Take a Look at Other Previews, Picks & Predictions For NFL Sunday Night Football Matchups

Chargers vs 49ers Betting Lines

Chargers vs 49ers Picks & Prediction

Both teams have key players hurt, but the 49ers are coming off a week of much-needed rest. They figure to be a little sharper and more energetic.

The Chargers are playing their second straight road game, which could lead to some fatigue as well. With kicking and pass rush concerns due to injuries to Joey Bosa and Dustin Hopkins, the 49ers get the edge in the sportsbook.

McCaffrey should make the difference for them in a 10-point win.

The San Francisco 49ers are listed at -300 in our Vegas NFL lines. This means that if you wager $100 on the 49ers, you have a chance to win $33. The Los Angeles Chargers are +250, offering a chance to win $250 on a $100 wager.

The implied probability attached to the betting lines gives the San Francisco 49ers a 75.00% chance to win, with the Los Angeles Chargers at 28.57%.

Don’t forget to stay tuned to BetUS Sportsbook & Casino and take a look at Sunday Night Football tonight odds!

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Chargers vs 49ers Edge

Chargers vs 49ers Results

Chargers vs 49ers Game Scorebox

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