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Rams vs Saints Prediction, Game Preview, Live Stream, Odds & Picks

The Los Angeles Rams have been dealing with all sorts of injuries this season, and the hits just keep coming. Playing in a game without quarterback Matt Stafford last week, the team also lost star wideout, Cooper Kupp.

Now the Rams go on the road to face the New Orleans Saints, who are also going nowhere. However, they’re healthier and more competent right now.

Rams vs Saints Odds, Game Preview, Live Stream, Picks & Predictions
Rams vs Saints Odds, Game Preview, Live Stream, Picks & Predictions

Does that mean the Saints are the best bet on the NFL betting odds? Let’s take a closer look.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Rams vs Saints. We’ve plenty of Vegas NFL odds and NFL week 11 picks for you to consider.


It is going from bad to worse for the defending Super Bowl champions, who are unlikely to make the playoffs. They lost 27-17 at home to the Arizona Cardinals last weekend on a day when Matthew Stafford did not play.

Backup John Wolford predictably struggled against an Arizona team that did not have Kyler Murray in the lineup.

Arizona went with backup Colt McCoy, who was better than Wolford in a game that was 27-10 late in the fourth quarter before the Rams scored a meaningless touchdown with seven seconds left.

The Rams hope that Stafford can play this weekend, but even if he does, he won’t have his favorite and most trusted receiver on the field.

Cooper Kupp got hurt and will be out for at least five weeks, if not more. This is a crushing loss for the Rams, who have no particularly good wide receivers due to injury.

It will be a challenge for Stafford to generate offense for the rest of the season.


It has been hard for the Saints to generate offense as well. They only scored 13 points at home two weeks ago in a loss to the Ravens.

Last week, they managed just 10 points in a punchless loss to the Pittsburgh Steelers. Saints fans wonder if Jameis Winston, benched for most of the season with an injury, can come back into the lineup.

Nothing about the offense inspires confidence right now. The defense will need to shut down the Rams – and those who bet online know it’s very possible – and remove the burden from the offense to win this game.

Rams vs Saints Game Injuries

Rams vs Saints Head-to-Head

These teams last met in 2019. The Rams won 27-9.

Rams vs Saints Game Information

  • Game: Rams vs Saints
  • Date: November 20, 2022
  • Time: 1:00 p.m. ET
  • Location: Louisiana Superdome, New Orleans, LA
  • How to watch Rams vs Saints? FOX
    Rams vs Saints Live stream: NFL Game Pass

Rams vs Saints Betting Lines

Rams vs Saints Picks & Prediction

These two teams are going to struggle to score, but the Rams have fewer options with Cooper Kupp out. The under is probably a strong play in the sportsbook because the Rams won’t score many points here.

Take the Saints with your NFL picks in terms of the side, if only because the Rams just don’t have anyone who can threaten the Saints’ defense.

The New Orleans Saints are listed at -175 in our Vegas lines. This means that if you wager $100 on the New Orleans Saints, you have a chance to win $57. The Los Angeles Rams are +150, offering a chance to win $150 on a $100 wager.

The implied probability attached to the betting lines gives the New Orleans Saints a 63.64% chance to win, with the Los Angeles Rams at 40.00%.

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Rams vs Saints Edge

Rams vs Saints Results

Rams vs Saints Game Summary

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