Skip to content

Rams vs 49ers Prediction, Game Preview, Live Stream, Picks & Odds

San Francisco Looks to Exact Revenge Against LA

The San Francisco 49ers meet the Los Angeles Rams for the first time since being eliminated in last season’s NFC Championship Game on the MNF odds. Revenge is on Kyle Shanahan’s mind as he looks to continue beating former colleague Sean McVay in the regular season. Shanahan is 7-3 against McVay (both straight-up and against the spread (ATS). That’s why the NFL betting lines favor San Francisco even if it is ever so slightly.

Which of these teams is the best choice for the Monday night football odds?

Rams vs 49ers Odds, Game Preview, Live Stream, Picks & Predictions
Rams vs 49ers Odds, Game Preview, Live Stream, Picks & Predictions

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Rams vs 49ers. We’ve plenty of Vegas NFL odds for you to consider.

Rams Not at Peak Powers Yet

Don’t be fooled by the Rams’ nonchalant win over Arizona last week. Sean McVay is to Kliff Kingsbury what Kyle Shanahan is to him: kryptonite. The Rams are not the same juggernaut they were in 2021, even if they are still a formidable outfit. Matthew Stafford had a horrendous Week 1 but has rebounded with two solid performances in both of Los Angeles’ wins.

However, the team has virtually no running game. Los Angeles has the third-fewest rushing yards in the NFL. Cam Akers does not appear fully recovered from his injury. This is an impediment to the defense, which is already struggling in itself. The Rams are last in pressure rate and 29th in passes defended.

Now, that is no reason to be alarmed as Los Angeles is still just allowing opposing quarterbacks an 89.3 passer rating. But those stats may just indicate that this team is more vulnerable, something worth noting before betting online.

San Francisco Can’t Catch a Break

The 49ers are feeling the jinx this season. The team opened at Chicago in a thunderstorm and lost Trey Lance for the season in Week 2. In Week 3, the team kept tripping over itself (sometimes, literally). Jimmy Garoppolo should shoulder much of the blame he was mostly responsible for the team scoring just 10 points.

Garoppolo is definitely “not it” as the team’s quarterback, to put it lightly. But thankfully for him, the 49ers are stacked and playing well everywhere else. San Francisco leads the NFL in passing defense and has allowed the lowest first-down conversion rate. The team is also sixth in rushing yards.

If Garoppolo continues to struggle, the team will continue to get hamstrung as it did in Week 3. However, Jimmy G should continue to improve down the stretch. He didn’t get any reps in the preseason and is rusty. He won’t be turning into a Pro Bowler, but he’ll be more reliable down the stretch.

Rams vs 49ers Game Injuries

Rams vs 49ers Head-to-Head

The Niners are 7-3 straight-up and ATS against the Rams in their last 10 meetings. However, the score differential has been close at just 2.4 points for the 49ers. The total has also gone under in seven of the last nine meetings.

Rams vs 49ers Game Information

  • Date: Monday, Oct. 3
  • Time: 8:15 p.m. ET
  • Location: Levi’s Stadium, Santa Clara, CA
  • How to watch Rams vs 49ers? ESPN
    Rams vs 49ers Live Stream: NFL Game Pass

Rams vs 49ers Betting Lines

Rams vs 49ers Prediction

We can clown Garoppolo all we want. But he has a good chance to bounce back against the Rams, a team he is unbeaten against (6-0). He is still a bit rusty since he didn’t get any reps in the preseason. But with another week with the offense, he should play a bit better. The Niners’ defense will also keep this game close enough for him to do work.

Most notably, the reason why Shanahan’s 49ers tend to beat McVay’s Rams is because of the physicality. San Francisco plays with a chip on its shoulders, which will be even bigger as the 49ers were eliminated by the Rams in the playoffs. So bank on the Niners in the sportsbook.

Don’t forget to stay tuned to BetUS Sportsbook & Casino and take a look at Monday Night Football tonight odds!

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Rams vs 49ers Edge

Rams vs 49ers Results

Rams vs 49ers Game Scorebox

Take a Look at Other 2 Previews, Picks & Predictions For NFL Monday Night Football Matchups

Featured Picks

Related News
College football picks
College football picks
Baylor Bears
Arkansas Razorbacks
Alabama Crimson Tide
Clemson Tigers
College football picks