Vikings vs Bills Prediction, Game Preview, Live Stream, Odds & Picks
Minnesota Lays Siege to Vulnerable Bills
The Minnesota Vikings head to Orchard Park looking to exploit the Buffalo Bills, who are coming off a loss and could be without its superstar quarterback: Josh Allen. As such, the NFL betting lines have trended for Minnesota, with the spread now down to -3½ points from -9½ in favor of Buffalo. Should Allen sit, it will be up to a pair of former Vikings to lead Buffalo.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Vikings vs Bills. We’ve plenty of Vegas NFL odds and NFL week 10 picks for you to consider.

Don’t Player-Hate on “Kirk Thuggins”
Love him or hate him, you can’t deny that the Vikings are 7-1 with Kirk Cousins as the quarterback. He has mediocre stats this season: 15th in passer rating (89.5) and 14th in touchdown percent (4.3). But he is currently in the top three in fourth-quarter comebacks (4) and game-winning drives (4).
Kirk Cousins acting uppic.twitter.com/dtYkVjvY0o
— Overtime (@overtime) November 6, 2022
Cousins leads the eighth-best scoring offense in the NFL (24.1 points per game). Most notably, Minnesota has won its last six games by one score. This team finds ways to win under new coach Kevin O’Connell, which is the opposite under Mike Zimmer.
The defense also deserves plenty of credit. This unit has already forced 14 turnovers, the fifth-most in the NFL. With Cousins and the offense taking care of the ball (fourth-fewest turnovers), Minnesota is +6 in turnover differential. That’s what makes them worth betting online.
The Buffalo Miracle
Could we have a sequel to the Minneapolis Miracle? Case Keenum could be stepping for Allen if the latter is out. Head coach Sean McDermott has been noncommittal on Allen’s availability though his injury, a UCL problem on his elbow, could be a serious one. The Bills may elect to not risk long-term damage to their franchise QB.
Keenum enjoyed his best years as a starter with Minnesota, where he went 11-3. Overall, he has a career record of 29-35 and a passer rating of 85.2 in 78 games played – 64 as the starter. He played his old team once: a loss in 2019 with Washington, where he completed 12-of-16 passes with no touchdowns or interceptions.
Should he start, watch the online sports betting lines switch. It won’t be surprising if Buffalo becomes the underdog. Buffalo is 10-11 (10-9-2 against the spread (ATS)) under McDermott without Allen as the quarterback.
Vikings vs Bills Game Injuries
Vikings vs Bills Head-to-Head
The Bills have won four of their last five games against the Vikings. In their only meeting in the McDermott era for Buffalo, the Bills blew out Minnesota 27-6 despite being 16½-point underdogs. The ‘under’ cashed on the totals in three of Buffalo’s four wins.
Vikings vs Bills Game Information
- Game: Vikings vs Bills
- Date: Sunday, Nov. 13th
- Time: 1:00 p.m. ET
- Location: Highmark Stadium, Orchard Park, NY
- How to Watch Vikings vs Bills? ESPN
Vikings vs Bills Live stream: NFL Game Pass
Vikings vs Bills Betting Lines
Vikings vs Bills Picks & Prediction
Folks betting on the Vikings should do it now while they are at this line. Even if Allen plays, he will not be fully himself. His elbow injury can debilitate his ability to throw deep or accurately, as it happened with Matthew Stafford this season. The Bills heavily depend on Allen. So whether you take the points or tease the Vikings, side with them or pass.
The Buffalo Bills are listed at -185 in our Vegas NFL lines. This means that if you wager $100 on the Bills, you have a chance to win $54. The Minnesota Vikings are +160, offering a chance to win $160 on a $100 wager.
The implied probability attached to the betting lines gives the Bills a 64.91% chance to win, with the Vikings at 38.46%.
“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”
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