Eagles vs Cardinals Prediction, Game Preview, Live Stream, Odds & Picks
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Eagles vs Cardinals Betting Analysis
Battle of the Birds
The Philadelphia Eagles have a target on their back Sunday. An underperforming team tries to get their props by beating the league’s lone undefeated. That’s what the Arizona Cardinals hope to do when the Eagles (4-0) come to town. Philadelphia has been a complete team thus season, while the Cardinals (2-2) are a wildly inconsistent outfit.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines for the Eagles vs Cardinals. We’ve plenty of NFL Vegas odds for you to consider.

Philadelphia Eagles
So, after starting 3-0, it was the Philadelphia Eagles’ offense getting the credit. Quarterback Jalen Hurts was playing at an MVP-caliber level, while the line and top wide receiver A.J. Brown dominated. It was the defense overshadowed, despite its excellent play to begin the season. However, a 29-21 win against the Jacksonville Jaguars gave the defense its due.
Forcing five turnovers, including two strip-sacks by edge rusher Haason Reddick (four team sacks total), the Eagles lead the NFL in sacks (16). Philly also has perhaps the best cornerback duo in the league. Darius Slay has been the league’s best, and James Bradberry has played well on the other side. Elite pass rushing with stingy corners tandem usually leads to success.
While the passing was not as good, the run game had its moments, 210 yards (4.2 yards per carry), as Miles Sanders had a career-high 134 yards.
Miles Sanders has 102 rushing yards +22 receiving yards
— John Clark (@JClarkNBCS) October 2, 2022
Led by the NFL’s best offensive line, there is sky-high potential, since opposing defenses have to take Hurts’ legs into account.
Arizona Cardinals
The Arizona Cardinals are moving the needle, that after a 26-16 home win over the Carolina Panthers. Offense had its best half of the season. Arizona trailed, 10-3, at halftime, then 23 unanswered points.
Quarterback Kyler Murray cooked Carolina’s defense. He finished with 207 passing yards, two touchdowns and a 96.7 passer rating. Against the Philadelphia Eagles’ elite pass rush, Murray will have to make more plays with his legs. In addition, wide receiver Marquise Brown had another great game (88 yards, one touchdown).
Arizona’s defense also comes off a decent performance. Outside of defensive tackle J.J. Watt, it lacks a consistent pass rush. Defensive end Zach Allen led with one sack, two quarterback hits and three pass deflections. Allen may become a pivotal piece of the defense. In the secondary, safety Budda Baker and cornerback Byron Murphy continued their good play as well.
Facing one of the NFL’s top dogs will show where Arizona stands.
Eagles vs Cardinals Game Injuries
Eagles vs Cardinals Head-to-Head
The Cardinals have controlled this series of late, 6-2 in the last eight. Philadelphia’s last win in Arizona was back in 2001.
Eagles vs Cardinals Game Information
- Date: Sunday, Oct. 9th
- Time: 4:25 p.m. ET
- Location: State Farm Stadium, Glendale, AZ
- Eagles vs Cardinals Live stream: NFL Game Pass
Eagles vs Cardinals Betting Lines
Eagles vs Cardinals Prediction
While the Cardinals showed promise in Week 4, they were playing the Carolina Panthers, one of the NFL’s worst teams. Philadelphia is whole different beast. The lines of scrimmage are where Eagles have dominated. Arizona’s defensive line has struggled lately, and the offensive line is hampered by several injuries. Philly will cover as it takes over the trenches.
“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”