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Home » Bet On NFL Games 2022 » NFL Matchups » Steelers vs Bills Prediction, Game Preview, Live Stream, Odds & Picks

Steelers vs Bills Prediction, Game Preview, Live Stream, Odds & Picks

Buffalo Ready To Dominate Against Pittsburgh

Paolo Go by Paolo Go
Oct 6, 2022, 9:00am ET
in NFL Matchups
Steelers vs Bills Odds, Game Preview, Live Stream, Picks & Predictions

Steelers vs Bills Odds, Game Preview, Live Stream, Picks & Predictions

After struggling through a pair of road games, the Buffalo Bills return to Orchard Park as Week 5’s biggest favorites. Buffalo will play host to Pittsburgh, which upset them in last season’s home opener. The NFL betting odds are spotting the Steelers two touchdowns (+14). The Bills are 3-7 against the spread (ATS) in their last 10 games against Pittsburgh but are the best at blowing opponents out.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Steelers vs Bills. We’ve plenty of NFL Vegas odds for you to consider.

Pickett Must Have a Steel Stomach

Kenny Pickett is officially the Pittsburgh Steelers’ starter. It comes as little surprise as he is the team’s new franchise quarterback. However, the team is right to be concerned for him as he makes his first NFL start against the Super Bowl favorites: the Bills.

The rookie will get roughed up by the Bills. Pickett threw three picks against the Jets and will now contend with the Bills’ fearsome defense. Buffalo has 11 sacks and is tied for sixth in the league pressure rate (27.7%). Pittsburgh’s offensive line will get manhandled as its already struggling offense tanks more.

Will Pickett turn the team around? Pittsburgh is ranked 28th in the NFL in expected points contributed on offense (-15.39). Pickett did turn the ball over a lot but he also rushed for two scores. With the team squarely behind him, the 24-year-old will bite his mouthguard and go at Buffalo hard.

Bills Ready To Bully Again

There is no team in the NFL better at crushing opponents than the Bills. This team will mow down anyone standing in its way. If the opponent can fight back, the Bills will struggle to close. But that is easier said than done as Buffalo’s average margin of victory since 2021 is a whopping 22 points.

Most wins by 14+ points since the start of last season: @BuffaloBills 12
5 teams tied w/ 7 pic.twitter.com/9eeYQQq60w

— NFL on CBS 🏈 (@NFLonCBS) October 5, 2022

The Bills are 5-1-2 ATS when favored by 10+ points. This team feeds off each other so when the defense gets going, the offense does, and vice versa. It just so happens Buffalo is a top-five unit on both ends: fifth in scoring offense and second in scoring defense. Josh Allen is a favorite to win MVP on the online sportsbook and Von Miller makes the pass rush even deadlier.

It will be a tall task to slow Buffalo down. On the defensive end, an opponent has to figure out how to slow Allen down. He’s arguably the best dual-threat quarterback and can extend plays or salvage them when the line breaks down. On offense, a team can look to exploit Buffalo’s thin secondary. But to do that, the line must hold up against a heavy front seven.

Steelers vs Bills Game Injuries

Steelers vs Bills Head-to-Head

Pittsburgh has won five of its last six games in Buffalo. Of course, most of this came before the Josh Allen era. Buffalo is 4-1-1 ATS in its last six games as a favorite. The total has gone under in six of Buffalo’s last seven games against Pittsburgh.

Steelers vs Bills Game Information

  • Date: Sunday, Oct. 9
  • Time: 1:00 p.m. ET
  • Location: Highmark Stadium, Orchard Park, NY
  • How to watch Steelers vs Bills? ESPN
    Steelers vs Bills Live Stream: NFL Game Pass
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Steelers vs Bills Betting Lines


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Steelers vs Bills Prediction

Buffalo should return to its dominant ways. Pittsburgh is no pushover on defense so there might be some resistance. But Pickett, as bold as he will be, will get picked apart by the Bills. He will get pressured constantly and turn the ball over a lot. The Bills’ defense may even score a few points off of his mistakes.

We expect the Bills to make a statement here and return to the top of the NFL Power Rankings. Laying the points is hefty, but the Bills are worth every bet online.

BET THIS PICK: Buffalo Bills -14

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

Steelers vs Bills Trends

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Tags: Buffalo BillsNFLNFL-Week-5Pittsburgh Steelers
Paolo Go

Paolo Go

As a long-time Toronto Raptors and Buffalo Bills fan, Go Paolo knows that every dog gets its day. Paolo fancies himself as an underdog in the sports betting world as he does not come from a traditional sports background. He did not become a hardcore sports fan until his freshman days in college studying Mass Media and Communications. While he played basketball and trained in martial arts, Paolo sees himself more as a nerd who cut his teeth in sports analysis by dropping truth bombs and stone-cold facts against crazed fans from online message boards. It was here he caught the attention of several sports journalists and website owners who gave him his start as a sportswriter. He has since published with the likes of Sportsnet and FanSided and has been writing about sports betting for over five years. Paolo is thrilled to continue covering sports and cannot wait to unearth more underdogs and unconventional winners.

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