San Francisco 49ers vs Arizona Cardinals

San Francisco 49ers vs Arizona Cardinals News & Picks

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San Francisco 49ers vs Arizona Cardinals Odds

Team Odds

Spread Totals Money-Line
San Francisco 49ers +6 -120 50  -110o +205
Arizona Cardinals  -6 Ev 50  -110u -245

**Odds as of 10/05**

The San Francisco 49ers (2-2) will head to the Grand Canyon State to take on the Arizona Cardinals (4-0) at State Farm Stadium in an intriguing NFC West matchup. Looking at the early NFL odds, they are heavily favoring the Arizona Cardinals at -6. The total is 50.

The 49ers are coming off a disappointing 28-21 loss to the Seahawks 28-21, while the Cardinals flat-out dominated the Rams 37-20 to remain the league’s only unbeaten team.

San Francisco could turn to rookie first-round pick Trey Lance after starting quarterback Jimmy Garoppolo suffered a calf injury in the first half against the Seahawks. It wasn’t pretty for the rookie, but Lance started the second half and threw for two touchdowns. A full week of game planning could potentially take this offense to a different level.

After sacking Russell Wilson three times, the pass rush went cold and never got to him again. The 49ers are strong against the pass, allowing just 218 yards per game. Their star-studded defensive line will face a red-hot Kyler Murray, who demolished the Rams’ defense.

Arizona went into Los Angeles and completely outplayed the Rams on every level. Murray is the front-runner for league MVP as he’s racked up 1.273 yards through the air with nine touchdowns and another three scores on the ground. The offense is clicking on all cylinders and leads the league in total offense.

The defense continues to impress after shutting down a lethal Sean McVay-led offense. The Cardinals held the Rams to just 20 points and they allow 21 points per game.

Despite injuries in the secondary, the Cardinals have created some huge turnovers and everyone is contributing on defense. Byron Murphy has turned into a star, picking off his fourth ball off in his last three games. They’ll need another strong defensive performance against another offensive guru.

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