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49ers vs Panthers Prediction, Preview, Stream, Odds & Picks

The San Francisco 49ers (2-2) are coming off a big Monday night win. Now, they take on the Carolina Panthers (1-3) in Charlotte. Whether the Niners were that good, or the Los Angeles Rams just stunk Monday, it was a much-needed (24-9) win. Carolina lost, 26-16, at the Arizona Cardinals.

At least against the Rams, San Francisco showed the world that, Trey Lance or not, they’re a contender. With Jimmy Garopolo back at quarterback, it’s difficult to argue with his results in 2½ games since retaking the reins. The Panthers have the rest/travel advantage, but that’s seemingly about it.

49ers vs Panthers Odds, Game Preview, Live Stream, Picks & Predictions
49ers vs Panthers Odds, Game Preview, Live Stream, Picks & Predictions

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for 49ers vs Panthers. We’ve plenty of NFL Vegas odds for you to consider.

San Francisco 49ers

After what San Francisco did to the LA Rams Monday night, we’re somewhat surprised to see the spread at just a touchdown in this game. The 49ers shut down a Super Bowl-winning offense, and now have a ‘cupcake’ in the Panthers. Carolina’s awful offensively, ranking among the worst teams in football in yards gained, both on the ground or through the air.

The 49ers also do a lot of little things. San Francisco ranks eighth in takeaway margin per game, the Panthers 24th. Carolina surrenders 62½ offensive penalty yards per game or 15 more than the 49ers.

San Francisco has the tools to dismantle Carolina on both sides of the ball.

Carolina Panthers

Even with an extra day of rest to prepare, we don’t have a lot of faith in the Panthers and quarterback Baker Mayfield to get it done Sunday. Remember that the Niner defense is one of the best in the league, holding the reigning champs to three field goals.

Carolina’s dead-last in yards per game, and will have a hard time getting anything accomplished. The Panthers are 24th in rushing yards, and 30th in passing through four weeks of miserable play.

Mayfield hasn’t eclipsed 200 yards passing in the last three games, meaning the 49er secondary should have its way.

49ers vs Panthers Game Injuries

49ers vs Panthers Head-to-Head

This is the first meeting between the 49ers and Panthers since 2019, when San Francisco rolled Carolina, 51-13. The Panthers are 6-4 in their last 10 games versus San Francisco, however, 7-3 against the spread.

49ers vs Panthers Game Information

  • Game: 49ers (2-2) vs Panthers (1-3)
  • Date/Time: Sunday, Oct. 9th, 2022, 4:05 p.m. ET
  • Location: Bank of America Stadium, Charlotte, NC
  • How to Watch 49ers vs Panthers? ESPN
    49ers vs Panthers Live stream: NFL Game Pass

49ers vs Panthers Betting Lines

49ers vs Panthers Prediction

It’s a touchdown spread in this game, and it’s a beatable line after what the 49ers did to the Rams Monday night. The Panthers are a tier or two lower in terms of skill than the Rams, and their offense doesn’t produce. Look for the 49ers defense to feast, and Jimmy Garopollo’s offense to take another step forward.

“The odds and predictions in the article are based on time of writing and publication. They may differ as to when the actual event takes place.”

49ers vs Panthers Edge

49ers vs Panthers Results

49ers vs Panthers Game Summary

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