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49ers vs Rams Prediction, Game Preview, Live Stream, Odds & Picks
The San Francisco 49ers descend on the Los Angeles Rams at SoFi Stadium on Sunday in a game that marks their second meeting this season.
BetUS Sportsbook tips the Niners as the slim road favorites. They’re priced at -120 to win on the Moneyline while the point spread is nestled on a one-point line. The total for this game is a modest 43 points with the over and under juiced to -110, respectively.
Let’s check the latest NFL odds, stats, injury reports, and NFL lines for 49ers vs Rams. We’ve plenty of Vegas NFL odds for you to consider.
49ers vs Rams Betting Analysis
The Niners are coming off a humbling home defeat, losing to the Kansas City Chiefs 44-23 at Levi’s Stadium.
The Chiefs’ defense gave Jimmy Garoppolo fits while Patrick Mahomes and the Kansas City offense ran circles around the so-called elite Niners defense. In short, it was a mess.
Garoppolo went 25 of 37 for 303 yards, two touchdowns and one interception. He was sacked five times, fumbled the ball for a loss once and generally looked uncomfortable.
Jimmy Garoppolo threw a 5-yard Hail Mary. pic.twitter.com/y87BIkJLff
— Ryan G Hensley (@ryanghensley) October 24, 2022
On the heels of the defeat, the Niners slipped to a 3-4 record on the season and down to third place in the NFC West. They’re 3-4 against the spread (ATS) with a 1.7 winning margin on average.
Los Angeles Rams
The Rams went into the season as one of the betting online favorites to win Super Bowl 57, but seven weeks in and their chances of running it back are looking slim.
They are coming off a Week 7 bye. They enter Sunday’s pivotal divisional contest with a 3-3 record. This includes a 2-4 ATS record with a 3.1 losing margin on average.
“To see him back out on the grass for us is big time.”
🎙 OC Liam Coen on Brian Allen’s return. pic.twitter.com/qOeBcehObG
— Los Angeles Rams (@RamsNFL) October 27, 2022
The Rams went into their bye on the back of a much-needed win that snapped a two-game losing streak, However, beating the Carolina Panthers 24-10 is hardly something to hang one’s hat on.
Matthew Stafford has struggled all season long. He ranks 13th in the league with 1,578 passing yards and has just six touchdowns to eight interceptions to his credit.
49ers vs Rams Injury Report
49ers vs Rams Head-to-Head
The Los Angeles Rams lost the first meeting to the San Francisco 49ers 24-9 in Week 4. It marked their sixth regular-season loss in a row to the Niners.
San Francisco leads the head-to-head series 7-3-0 in their last 10 meetings. However, the Rams have the most important win between these two sides after beating the Niners 20-17 in the NFC Championship Game on the way to their Super Bowl 56 victory.
49ers vs Rams Game Information
- Game: 49ers vs Rams
- Date: Sunday, Oct… 30, 2022
- Time: 4:25 p.m. ET
- Location: SoFi Stadium, Los Angeles
- How to watch 49ers vs Rams? ESPN
49ers vs Rams Live stream: NFL Game Pass
49ers vs Rams Betting Lines
49ers vs Rams Prediction
Although the Rams currently rank ahead of the Niners in the NFC West, their standing is a moot point. It certainly hasn’t translated to favorable NFL odds for this much-anticipated NFC West tilt
The Rams are the underdogs for the third time this season and second time at home. They opened the season as the +2 home pups only to suffer an embarrassing 33-10 loss to the Buffalo Bills.
Similarly, the Rams barely whiffed at the +2 closing spread in the 24-9 loss to the Niners at Levi Stadium. So, it’s not surprising that they head into this game as the notional home underdogs for NFL picks against the spread.
Aside from last week’s debacle (and the bizarre 11-10 loss to the Denver Broncos in Week 3), the Niners have played relatively well. They’ve had reliable (sort of) quarterbacking from Garoppolo and solid production from the offense, but it’s their defense that has been the main driving force behind their successes this season.
Kyle Shanahan will be relying on that defense to get the job done against Stafford, who’s looked very vulnerable in the pocket and has a negative touchdown to interception differential.
Jimmy G had a good game the first time he faced this Rams defense. He should do so again. Especially with Christian McCaffrey joining the team last week and looking to make an impact in the run game.
Back the Niners to bounce back against a Rams team that is a shell of its Super Bowl-winning self.
The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.
