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San Francisco 49ers vs Minnesota Vikings

Familiar Foes

The Vikings will be meeting a familiar foe when the San Francisco 49ers travel to Minnesota on Saturday for the second game of the preseason. The teams are in opposite, yet similar, positions.

The 49ers are fresh off a 28-21 preseason win over the Green Bay Packers. Last season, they defeated the Packers in the playoffs as well.

San Francisco 49ers vs Minnesota Vikings
San Francisco 49ers vs Minnesota Vikings

San Francisco has a young quarterback in Trey Lance as the starter and a seasoned coach in Kyle Shanahan, who has led the team to a Super Bowl, albeit a loss to the Kansas City Chiefs.

The Vikings, on the other hand, missed out on the playoffs for the second straight season and fell in their first preseason game 26-20 to the Las Vegas Raiders. Minnesota goes into the new season with a veteran quarterback in Kirk Cousins, though new head coach Kevin O’Connell may bring growing pains.

San Francisco, competing in a division with the reigning Super Bowl champions, have the second-best odds (+175) to win the NFC West behind the Rams. The Vikings also have the second-best odds (+250) to win the NFC North behind the Packers, who have won the division three seasons in a row.

Let’s check the latest NFL news, stats, injury reports and NFL odds for 49ers vs Vikings. We’ve plenty of NFL picks and predictions for you to consider.

Lance’s Homecoming?

With the game to be played in Minnesota, it will act as sort of a homecoming for Lance, who grew up and went to high school in the state.

The Minnesota Vikings arranged for buses to bring players from Marshall High School, Lance’s alma mater, to view one of the joint practices between the teams.

However, while they’ll get to see Lance practicing, he’s unlikely to get into the game Saturday as Shanahan said the plan was for Lance to play in the first and third preseason games.

In the San Francisco 49ers’ opener against the Packers, Lance played two series, going 4 of 5 for 92 yards, including a 76-yard touchdown pass to rookie wide receiver Danny Gray.

Fans will likely see Nate Sudfeld and Brock Purdy. Sudfeld finished the first game 8 of 11 for 103 yards and a touchdown while Purdy went 3 of 6 for 36 yards and a touchdown.

Vikings’ Running Backs Show Out

Minnesota has a star running back on its roster in Dalvin Cook. However, with his injury history, the Vikings need a strong backup as well.

Alexander Mattison has previously held that role, but with a few backs showing out in the preseason opener, that may not be the case anymore.

Both rookie running back Ty Chandler and second-year pro-Kene Nwangwu had solid performances against Las Vegas.

Chandler led the team in rushing, finishing with five carries for 50 yards while Nwangwu rushed seven times for 41 yards. Nwangwu also had two receptions for 18 yards.

Mattison, for his part, finished with three carries for eight yards.

While Mattison finished 2021 with 134 rushes for 491 yards, Nwangwu made a splash as a kick returner, returning two kickoffs for touchdowns, including one that went for 99 yards.

Chandler, Nwangwu, and Mattison figure to get many of the reps once more as Minnesota figures out its running back situation.

49ers vs Vikings Injury Report

For the 49ers, defensive tackles Maurice Hurst and Kalia Davis, tight end Jordan Matthews and cornerback Jason Verrett are out. Cornerbacks Emmanuel Moseley, Jimmie Ward, Charvarius Ward and Dontae Johnson, defensive ends Arik Armstead and Drake Jackson, running back Elijah Mitchell, linebacker Curtis Robinson and offensive tackles Mike McGlinchey, Daniel Brunskill and Jaylon Moore are all questionable.

Wide receiver Blake Proehl and linebacker Ryan Connelly are out for the Vikings. Tight end Irv Smith Jr., running back Ty Chandler, wide receiver Dan Chisena, cornerback Parry Nickerson and guard Chris Reed are all questionable.

49ers vs Vikings Head-to-Head

This will be the 10th time the 49ers and Vikings match up in the preseason, with the last meeting taking place in 2017. The series has been pretty even in the preseason, with the 49ers leading the series 5-4.

The teams have met each other 49 times in the regular season, with the Niners leading the series 25-23-1. San Francisco has owned the series recently, with the Vikings not winning since 2007. The 49ers’ most recent win (34-26) came in San Francisco on Nov. 28, 2021.

49ers vs Vikings Game Information

  • Game: San Francisco 49ers vs Minnesota Vikings
  • Location: U.S. Bank Stadium, Minneapolis, MN
  • Day/Time: Saturday, Aug. 20, 7 p.m. ET
  • Live stream: NFL Game Pass

49ers vs Vikings Betting Lines

Team Point Spread Moneyline Total Team Total
San Francisco 49ers +4½ -105 +175 39½ -110o 17 -115o
17 -115u
Minnesota Vikings -4½ -115 -210 39½ -110u 21½  -115o
21½ -115u

49ers vs Vikings Prediction

While the 49ers are coming off of a win in their preseason opener, the Vikings are looking for their first win.

Minnesota was able to run the ball and backup QB Kellen Mond had a solid game. Even if Lance sits for the Niners, San Francisco’s backups played well in their previous outing, with the 49ers’ defense also getting three interceptions against the Packers.

This figures to be another close preseason game, but the Niners should be able to roll out of Minnesota with another win.

49ers vs Vikings Edge

49ers vs Vikings Results

49ers vs Vikings Game Injuries

49ers vs Vikings Game Summary

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