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Saints vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks

Niners Look To Dominate Chippy Saints

The San Francisco 49ers have a shot at winning four straight as they play host to the New Orleans Saints in Week 12. With all the momentum, the Niners are expected to blow out the Saints on Sunday with a spread of 10 points per the NFL betting lines. This makes it the largest spread the Niners have to cover in which they are 2-1-0 as an NFL pick against the spread as a favored host.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Saints vs 49ers. We’ve plenty of Vegas NFL odds for you to consider.

Saints vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks
Saints vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks

Saints vs 49ers Betting Lines

Homesick Saints are Hapless on the Road

The wide betting lines are a combination of the Niners’ potency and the Saints’ poor road performances. Dennis Allen’s team, supposedly a defensive one, gives up the fifth-most points on the road (27.6) and the second-longest average time of possession (33:12). In short: this team can’t get a stop.

Like many teams this season (including San Francisco), New Orleans can blame injuries. Several key members of its defense are banged up or on the injury report. Defensive back Marshon Lattimore (foot) and edge rusher Marcus Davenport (calf) are two examples.

Meanwhile, classic quarterback Andy Dalton is quietly having a solid comeback campaign. New Orleans’ offense has been more efficient with Dalton and is averaging 24.8 points compared to 17 in their first three games with Jameis Winston. Dalton has also committed fewer turnovers. With him running the show, New Orleans is a bit easier to bet online.

San Francisco Building Momentum

San Francisco is picking up steam on both ends of the turf. This team looks like the Super Bowl dark horse we predicted in the preseason but with Jimmy Garoppolo back as the leader. The 31-year-old quarterback is averaging a career-best 104.1 passer rating as a full-time starter. He’s tossed 15 touchdowns to four picks. And he has the front office to thank.

The Niners have a stacked team. Acquiring Christian McCaffrey gives them a running back who, like receiver Deebo Samuel, is a swiss army knife. This has allowed Kyle Shanahan to open up the playbook. But not only is San Francisco putting up 28.5 points, but the defense has also been on fire.

San Francisco is allowing 13.3 points and 4.2 yards per play in their last three games. Only New England has it beat in both categories. Even with injuries up front, the Niners are peaking.

Saints vs 49ers Game Injuries

Saints vs 49ers Head to Head

San Francisco is 2-2 ATS as a home team while the Saints are 0-4 ATS as a road team. More conspicuous however is how these teams’ meetings tend to be high-scoring. Seven of their last 10 have gone over the total.

Saints vs 49ers Game Information

  • Game: Saints vs 49ers
  • Date/Time: Sunday, Nov. 27, 2022, 4:25 p.m. ET
  • Location: Levi’s Stadium, Santa Clara, California
  • How to watch Saints vs 49ers: FOX
    Saints vs 49ers Live stream: NFL Game Pass

Saints vs 49ers Game Weather Conditions

It will be fair weather with 66 degrees Fahrenheit, a slight wind (10 miles per hour), and just around 20% chance of precipitation. Solid football weather.

Saints vs 49ers Game Picks & Prediction

Predicted Score: Saints 29, 49ers 23

  • Worth betting on the Moneyline?

It would be tough to find any value on San Francisco’s line here at -460. For the best bet, throw San Francisco in a parlay to improve the line. While +345 is a hefty return for New Orleans, we can’t back the Saints to win.

  • Worth Betting ATS?

Even the spread can be difficult to bet here. But if one is to pick a side, lay the points on the Niners. This team is better on both sides of the ball and is 3-1 ATS when favored by nine or more points since last season.

  • Worth betting on the Totals?

This is this game’s best bet on the sportsbook. The Niners are on a roll on offense and defense. The Saints’ generous defense will let San Francisco score at will. On the flip side, Dalton and the Saints could put up enough points to cover the “over.”.

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Saints vs 49ers Edge

Saints vs 49ers Results

Saints vs 49ers Game Summary

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