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49ers vs Seahawks Prediction, Game Preview, Live Stream, Odds and Picks

Who Will Be at QB for the 49ers?

The 49ers looked just fine with rookie Brock Purdy at quarterback in a win over the Tampa Bay Buccaneers on Sunday. With San Francisco already down injured quarterbacks Trey Lance and Jimmy Garoppolo, Purdy is now dealing with an oblique injury. He looks to be on track to play, but the same can’t be said about star receiver Deebo Samuel as he is expected to be sidelined due to an ankle injury. Running back Christian McCaffrey is also on the injury list.

Seattle might be without rookie running back Kenneth Walker for the second game in a row and having the game on Thursday rather than Sunday is probably not helpful as Walker works his way back from his own ankle injury.

49ers vs Seahawks Prediction, Game Preview, Live Stream, Odds and Picks
49ers vs Seahawks Prediction, Game Preview, Live Stream, Odds and Picks

Seattle is coming off a loss to Carolina Sunday that could prove costly to its playoff chances, while the 49ers not only have a two-game lead in the NFC West but are 4-0 in division play.

Per the NFL playoff odds, the 49ers (+350) are tied for the second-best odds to represent the NFC in the Super Bowl. The Seahawks (+2800) are sixth in the NFC championship odds.

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for 49ers vs Seahawks. We’ve plenty of Vegas NFL odds and NFL week 15 picks for you to consider.

49ers vs Seahawks Betting Lines

Eyeing a Road Win

San Francisco has been merely average on the road this season with a 3-3 record, losing to the Falcons, Broncos, and Bears. It will be interesting to see how the 49ers handle a trip to face a desperate Seattle team.

When the teams played back in September, Seattle was just 2 of 7 on third downs and managed only 216 yards. Three turnovers proved costly as a San Francisco defense that allows the fewest yards per game in the NFL made life difficult for journeyman quarterback Geno Smith.

With the way the 49ers disrupted future Hall of Famer Tom Brady in last week’s impressive win over Tampa Bay, it is hard to pick against the 49ers in this one.

San Francisco has covered against the NFL betting lines in five of its last six games.

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Battle Tested

Seattle knows something about playing in tight games, with eight of them being decided by seven points or less. Being in close contests is one thing; winning those games is another. The Seahawks are just 3-5 in one-score games, leaving the Seahawks fighting to make the playoffs rather than competing for the division title.

A win on Thursday would pull Seattle within a game of the division-leading 49ers. However, the Seahawks will need a better effort from Smith. The front-runner for the NFL Comeback Player of the Year according to the NFL betting odds, Smith failed to complete at least 60% of his passes for the first time this season and threw a pair of costly interceptions in the six-point loss to Carolina.

He has thrown four interceptions over the last three games, and things have become tougher for him and the Seattle offense.

The Seahawks have covered against the Las Vegas odds in just one of its last five games.

49ers vs Seahawks Game Injuries

49ers vs Seahawks Head-to-Head

San Francisco snapped a four-game losing streak to the Seahawks with a 27-7 home win on Sept. 18 as an 8½-point favorite.

Six of the previous eight games in the series were decided by seven points or less, with just two of the last nine matchups finished under the total.

The road team has won six of the last games between Seattle and San Francisco.

49ers vs Seahawks Game Information

  • Game: 49ers vs Seahawks
  • Date/Time: Thursday, Dec. 15, 8:15 p.m. ET
  • Location: Lumen Field, Seattle, WA
  • 49ers vs Seahawks Live stream: NFL Game Pass

Take a Look at Other 2 Previews, Picks & Predictions For NFL Week 15 Matchups

49ers vs Seahawks Game Weather Conditions

Temperatures are expected to be in the low 40s as the weather isn’t expected to have much of an impact on the game.

49ers vs Seahawks Picks & Prediction

Predicted Score: 49ers 24, Seahawks 20

  • Worth Betting on the Moneyline?

Seattle dropping three of its last four games hasn’t helped those who bet online with the 49ers having a Moneyline of -185. There are some injury concerns on offense for the 49ers. However, the defense looks pretty healthy and that could make things challenging for Seattle at home.

With everything at stake for Seattle, expect the Seahawks to push the 49ers in this one. Can they figure out how to win a close game? With a +160 Moneyline, it could be worth taking a chance on the home underdogs.

  • Worth Betting ATS?

The 49ers have been very solid against the spread but it could be a little risky taking the 49ers as a 3½-point favorite until more is known about the availability of running back Christian McCaffrey and quarterback Brock Purdy.

Something for those who bet online to consider: each of Seattle’s last four games have been decided by six points or less.

  • Worth Betting on the Totals?

With the way the 49ers get after it on the defensive side of the ball, it is not surprising to see the total set at 43½. Just 34 points were scored when the teams played earlier in the season. Four of the last five games played by Seattle went over that number, so this is a dangerous game to bet on the total.


49ers vs Seahawks Edge

49ers vs Seahawks Results

49ers vs Seahawks Game Summary

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