Buccaneers vs 49ers Prediction, Game Preview, Live Stream, Odds & Picks

Buccaneers to Test Dominant 49er “D”

· Dec 09 - 5 minutes read

The Tampa Bay Buccaneers pulled out an improbable home win over the New Orleans Saints this past Monday night. It was a game that many could argue they didn’t deserve.

However, Tom Brady was able to capitalize once the Saints’ mistakes compiled. He and the NFC South-leading Buccaneers meet arguably the best defense in football.

Buccaneers vs 49ers Odds, Game Preview, Live Stream, Picks & Predictions

While the 49ers defense is stingy, the team now has its first full game with Brock Purdy at quarterback. Is under an easy bet online, or is there a better option in the sportsbook?

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for Buccaneers vs 49ers. We’ve plenty of Vegas NFL odds and NFL week 14 picks for you to consider.

Buccaneers vs 49ers Betting Lines

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Buccaneers Don’t Look Good

It wasn’t pretty, and it was aided by the other side, but Tampa Bay came away with a 17-16 win last week. It didn’t play well over the first three-and-a-half quarters. That can’t be ignored.

Brady missed on a variety of big-time throws to Julio Jones down the field, and the rushing attack didn’t produce. Despite the skilled players on this side of the ball, they only average 18.1 points per game, the sixth-lowest total in the league.

They’ll struggle to hit that number in Brady’s Northern California homecoming this week

49ers Defense Is Phenomenal

One can’t overstate how good the San Francisco 49ers defense has been playing. They’re the best in the league in limiting both opponents’ yards (283,9) and points (15.8) per game.

They hadn’t allowed a single point in the second half over a four-week span before that was breached by the Miami Dolphins last week.

How will the offense fare in the first start by quarterback Brock Purdy? Jimmy Garoppolo is out at least the rest of the regular season. Purdy wasn’t overwhelmed against the Fish, but now sees a strong Bucs defense that’s had time to prepare.

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Buccaneers vs 49ers Game Injuries

Buccaneers vs 49ers Head-to-Head

These two squads haven’t met since 2019, with the 49ers winning by a count of 31-17.

Buccaneers vs 49ers Game Information

Game: Buccaneers (6-6) vs 49ers (8-4)
Day/Time: Sunday, Dec. 11th, 4:25 p.m. ET
Location: Levi’s Stadium, Santa Clara, CA
Buccaneers vs 49ers Live Stream: NFL Game Pass

Buccaneers vs 49ers Game Weather Conditions

Expected to be 52 degrees at kickoff, with rain throughout the game.

Buccaneers vs 49ers Picks & Prediction

Predicted Score: 49ers 20, Buccaneers 10

Worth the Moneyline?

Moneyline is favoring the 49ers at a -180 price, and it seems like a solid option here for your NFL picks. Tampa hasn’t looked great of late, and the 49ers defense is stellar.

Purdy is a concern, but did appear solid against Miami last Sunday. They’re at home, so the crowd should give them an edge.

Worth the ATS?

It’s at 3½ points in favor of the 49ers, which shouldn’t be too difficult to surpass. If Purdy doesn’t crumble under the pressure of playing against Brady, the home side figures to win.

Offenses struggle to move the ball, so avoiding turnovers will be key.

Worth the Totals?

As of now, the NFL odds have a point total of 37½. The under looks the play, despite the total being on the lower end. Factor in the 49ers excellent defense against a mundane Buccaneer offense this season. Then, the first start of Purdy has him trying to just manage the game.

BET THIS PICK: 49ers at a -180

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.