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Titans vs Bills Prediction, Game Preview, Live Stream, Picks & Odds

What a difference a year can make or perhaps a year and a game. The Tennessee Titans entered the playoffs in 2021 as the No. 1 seed in the AFC. However, after trading star receiver A.J. Brown and seeing pass-rushing linebacker Harold Landry lost due to injury, expectations are a little lower.

It didn’t help that Tennessee fell to the New York Giants in the season opener. The Titans are double-digit underdogs when heading to play a Buffalo team that is favored to win the Super Bowl title.

Titans vs Bills Odds, Game Preview, Live Stream, Picks & Predictions

Tennessee still has running back Derrick Henry and he has proven he can pick up yards and help the Titans sustain drives even against defenses as physical as Buffalo’s.

According to the NFL odds, Buffalo (+275) has the best odds to represent the AFC in the Super Bowl while Tennessee comes in at +2000.

Which of these teams is the best choice for the Monday night football odds

Let’s check the latest, news, stats, injury reports, and NFL lines for Titans vs Bills. We’ve plenty of Vegas NFL odds for you to consider.

As well explore a variety of other NFL odds here to win!

Tennessee Titans

There were plenty of surprises in Week 1 of the NFL season. However, on the shock value meter, it might be hard to top the Giants edging the Tennessee Titans.

Tennessee led 13-0 at halftime after a team that was viewed years and not weeks away from becoming a playoff contender. However, after having a touchdown and two field goals on its first four drives, Tennessee’s offense only managed one more scoring drive.

Having Ryan Tannehill male 12 more passing attempts than Henry had rushing attempts doesn’t seem like a recipe for success.

Rookies Kyle Phillips and Treylon Burks combined for nine catches and 121 receiving yards so that was a positive sign.

Rashad Weaver, who had two assisted tackles in the two games he played in as a rookie, led the defense with two sacks.

The Titans have failed to cover against the NFL betting odds in six of their last nine games.

Buffalo Bills

The Buffalo Bills were already being touted as the team to beat in the NFL in 2022. They certainly lived up to that billing with a dismantling of the reigning Super Bowl champion Los Angeles Rams in the first game of the season.

The defense held a talented Rams offense to 3.7 yards per play and 243 total yards. Linebacker Tremaine Edmunds led the way with 10 tackles, defensive tackle Jordan Phillips had 1.5 sacks.

Josh Allen not only threw for nearly 300 yards to go with three touchdowns, but he was also the leading rusher for the Bills with 56 yards. He scored Buffalo’s only touchdown on the ground.

Stefon Diggs‘ connection with Allen remained as strong as ever. He had 122 yards on eight catches. Gabriel Davis joined Diggs by being on the end of TD passes from Allen. He averaged 22 yards on his four catches.

Something to consider for those who bet online, the Bills are 4-1-1 against the spread in their last six contests.

Titans vs Bills Injury Report

Linebacker Ola Adeyini (shoulder), cornerback Lonnie Johnson (groin), and offensive lineman Jamarco Jones (triceps) are questionable for the Titans. Linebacker Chance Campbell (knee), receiver Racey McMath and cornerback Elijah Molden (groin) are out indefinitely.

For Buffalo, offensive lineman Tommy Doyle (foot), tight end Quintin Morris (hamstring), defensive linemen Ed Oliver (ankle), and Tim Settle are questionable. Offensive lineman Ike Boettger (Achilles), receiver Marquez Stevenson (foot), and cornerback Tre’Davious White (knee) are out indefinitely.

Titans vs Bills Head-to-Head

The Titans have won each of the last two meetings. Tennessee won 34-31 as a six-point underdog at home on Oct. 18, 2021, as Henry’s 13-yard touchdown run gave the Titans the lead with 3:05 left to play. The 2020 meeting, also played in Nashville, was a 42-16 win for the Titans.

Buffalo won the previous three games in the series with Tennessee taking five in a row before Buffalo’s brief reversal of fortunes.

Six of the last seven games in the series have been decided by seven points or less

Titans vs Bills Game Information

  • Records: Titans 0-1, vs Bills 1-0
  • Date: Monday, Sept. 19
  • Time: 7:15 p.m. ET
  • Location: Highmark Stadium, Orchard Park, N.Y.
  • How to watch Titans vs Bills? ESPN
    Titans vs Bills Live Stream: NFL Game Pass

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Titans vs Bills Betting Lines

Titans vs Bills Prediction

A year ago, this could have been a potential AFC Championship Game preview. Tennessee was not a team getting much love heading into the season and following a loss to the New York Giants, expectations are falling more.

The Bills limited the Rams to 2.9 yards per carry. It is going to be a different story on the MNF odds with Henry coming to town. Keep an eye on the status of defensive lineman Ed Oliver as he figures to play a key role in trying to slow down Henry if he is able to go.

The total has gone under in five of Tennessee’s last six games while it has gone over in five of the last seven games for the Bills so something will have to give. There is no doubt that the Bills will be tough to beat, especially at home, but a 10-point line seems a bit high.

Don’t forget to stay tuned to BetUS Sportsbook & Casino and take a look at Monday Night Football tonight odds!

The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

Titans vs Bills Edge

Titans vs Bills Results

Titans vs Bills Game Injuries

Titans vs Bills Game Summary

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