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Titans vs Colts Prediction, Game Preview, Live Stream, Odds & Picks

Indianapolis Looks to Defend Home in Critical AFC Tilt

Titans vs Colts Betting Information

With the Jacksonville Jaguars slated to lose against Philadelphia, the Tennessee Titans or Indianapolis Colts could tie for or gain first place in the AFC South with a win here. The NFL betting odds favor the Colts, the home team, but the Titans have won their last two visits to Indianapolis and are 4-1 against the spread (ATS) in their last five games.

Check the latest news, stats, injury reports, and NFL odds for Tennessee Titans vs. Indianapolis Colts. There are plenty of NFL predictions for you to consider.

Titans vs Colts Odds, Game Preview, Live Stream, Picks & Predictions
Titans vs Colts Odds, Game Preview, Live Stream, Picks & Predictions

Let’s check the latest NFL odds, stats, injury reports, and NFL lines for the Titans vs Colts. We’ve plenty of Vegas NFL odds for you to consider.

Titans Prove to Be a Persistent Bunch

You can’t keep good men down. Mike Vrabel has the Tennessee Titans marching on despite getting beaten up and battered through the season. Tennessee is enduring what has been an injury-filled year with as many as nine starters listed on the injury list or still recovering from an injury. The most notable is Derrick Henry.

The once-unstoppable running back, who has been the team’s catalyst on offense, has not been the same. He is rushing for a career-low 3.6 yards-per-attempt. The offensive line is also a shell of itself with Taylor Lewan out. Ryan Tannehill is still readjusting to his new receivers – none have caught a touchdown yet.

The issues don’t stop on offense as the defense could be without Bud Dupree (hip), while Harold Landry III is out for the year with an ACL injury. As such, the Titans have given up over 390 yards per game. But knowing this team, it will find a way to do enough on both ends to make them worth betting online.

Riding This Rollercoaster of a Colts Season

Colts fans, the ride has not come to an end. Buckle up as you may be in for another “exciting” game. Indianapolis has alternated performances that have everyone scratching their heads. The team opened the season by dumping 517 yards on Houston only to walk away with a tie.

This offense, led by Matt Ryan on his last legs, is struggling to score. Indianapolis has scored the fewest points in the NFL, thanks to getting blanked by the Jaguars. But its defense, which has stayed solid, has carried the team. It pushed Indianapolis over Kansas City.


The Colts’ front seven is doing an admirable job in stuffing their opponents’ running game as it leads the league in yards-per-attempt (2.6) and is third in rushing yards allowed (231). And on their end, Jonathan Taylor remains a potent force with his legs. The Indianapolis Colts will be back in business if Ryan and the passing game can get things going.

Titans vs Colts Game Injuries

Titans vs Colts Head-to-Head

Both the Titans and Colts have struggled on the online sports betting lines lately. Both teams are just 1-4 ATS in their last five games. They have conservative playcalling with stalwart defenses hence the modest total. But four of their last five games against each other have gone ‘over’.

Titans vs Colts Game Information

  • Date: Sunday, Oct. 2nd
  • Time: 1:00 p.m. ET
  • Location: Lucas Oil Stadium, Indianapolis, IN
  • Titans vs Colts Live stream: NFL Game Pass

Titans vs Colts Betting Lines

Titans vs Colts Prediction

It’s hard to get a read on this game. The one thing we’re sure of is that both teams are struggling on the offensive end. But Indianapolis has more things going for them: the running game, a healthier team, and home advantage.

Fair play, the Titans have been comfortable inside the Lucas Oil Stadium. But Indianapolis is 10-4 as a favorite here since 2020. This game will get rocky at points, but we trust the Colts to be able to handle whatever the Titans throw at them.


The odds and predictions in the article are based on the time of writing and publication. They may differ as to when the actual event takes place.

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