NFL Week 1

Football fans around the world will be treated to the NFL regular season starting Thursday, September 9. 2021, and for all the betting enthusiasts out there we already have the NFL Week 1 Odds fully loaded. Be sure to check em and pick your favorites!

NFL Week 1: 2021 Preview

It all begins this Sept. 9: The 2021 NFL season. Finally, fans are back in the stands and we are entering an unprecedented 17-game schedule. The NFL Week 1 odds are ready and waiting as we look through each game.

NFL Games of the Week

Dallas Cowboys at Tampa Bay Buccaneers (-10)

Thursday, Sep. 9 – 8:20 p.m. ET
The betting lines have this as a blowout-in-the-making with Tampa Bay rudely welcoming Cowboys quarterback Dak Prescott back.
Tampa Bay went 12-8-0 against the spread (ATS) last season while Dallas had the worst record at 5-11 thanks to a myriad of injuries. Coach Mike McCarthy’s seat is on fire for Dallas and it’s also worth mentioning that the last two times they were featured on HBO’s Hard Knocks, they missed the postseason.
The Cowboys will also miss starting guard Zack Martin (COVID-19), which puts them at worse odds against one of the NFL’s best defenses. Tampa Bay is poised to dominate.

Pittsburgh Steelers at Buffalo Bills (-6½)

Sunday, Sep. 12 – 1 p.m. ET
This may be the beginning of Pittsburgh QB Ben Roethlisberger’s farewell tour. Heck, if Buffalo manages to rough him up enough he may just call it quits early. This isn’t too far off from happening as the Bills improved their pass rush while the Steelers’ offensive line fell apart.
Buffalo should be able to throttle Pittsburgh. As far as the spread goes, the Bills finished with a 12-7-0 record ATS putting them as the second-best team in this department. Pittsburgh covered four of their five games as an underdog so they could put up a fight here.

Jacksonville Jaguars (-3) at Houston Texans

Sunday, Sep. 12 – 1 p.m. ET
From a bad team to a brutal team, this AFC South matchup may be the worst of Week 1. QB messiah Trevor Lawrence couldn’t have been matched up against a better team as the circus that is the Texans is ripe for getting lit up.
We digress as the Jaguars’ offense isn’t that good either. It may be best to steer clear of this game as there are more holes and question marks here than there will be points. Although the totals lined at 45½ may be worth betting to go under.

Los Angeles Chargers at Washington Football Team (pk)

Sunday, Sep. 12 – 1 p.m. ET
NFL predictions have gone back-and-forth with this game. The Chargers bolstered their offensive line to better protect Justin Herbert, last year’s Offensive Rookie of the Year. With a healthy defense, the AFC’s L.A. team will look to return to the postseason.
But the Football Team has been there and done that. They have arguably the best defense in the conference and now have a bit more pop at quarterback. Coach Ron Rivera is 9-1 in Week 1. “Riverboat Ron’s” teams are always ready to play at the start of the season.

Seattle Seahawks (-3) at Indianapolis Colts

Sunday, Sep. 12 – 1 p.m. ET
Coaching geniuses meet head-to-head as Pete Carroll pits his Seahawks against Frank Reich’s Colts. Both were one-and-done in the postseason last year but have made a slew of changes: Seattle got Shane Waldron, of Sean McVay’s crew, to coach the offense while Reich reunited with QB Carson Wentz.
If these changes pay off, we could be in for a brilliant offensive showcase and the totals would easily go over 50. But these are big “ifs”, especially with Wentz coming off yet another injury and the Seahawks still needing to acclimate to Waldron’s schemes.

Minnesota Vikings (-3) at Cincinnati Bengals

Sunday, Sep. 12 – 1 p.m. ET
Minnesota has been the definition of inconsistent being unable to string together winning seasons. The defense is still solid as is the offense but the team just lacks that extra “oomph” that would make them a serious contender.
They get to prove they’re “legit” by beating up on the fledgling Bengals here. The Vikings were only 2-7 ATS as chalk last season after finishing 7-5 in 2019. But matchup-wise, Minnesota should be able to exploit a makeshift Bengals O-line. It’s only Week 1, but this is already a “must-win” game for Vikings coach Mike Zimmer and co.

San Francisco 49ers (-7½) at Detroit Lions

Sunday, Sep. 12 – 1 p.m. ET
Interestingly, support on the sportsbook has come mostly for the Lions. Spread underdogs tend to cover more on Week 1 than any other week so bettors are banking the Lions are one of those teams. On paper, Detroit could challenge Houston as the worst team in the league.
The Lions downgraded at quarterback and have one of the worst defenses in the NFL. The 49ers were a dominant bunch when fully healthy in 2019 going 11-7-1 on the spread and 15-4 straight-up. Regardless of who’s playing at quarterback, leave it to coach Kyle Shanahan to make the Niners play like Super Bowl contenders again.

New York Jets at Carolina Panthers (-4½)

Sunday, Sep. 12 – 1 p.m. ET
It’s a revenge game for the Panthers’ new quarterback: Sam Darnold. The former third-overall pick had three miserable seasons in New York before getting unceremoniously traded to Carolina as the team drafted BYU QB Zach Wilson.
Offensive line aside, Darnold has a much better team in front of him. Carolina’s defense could be a top-10 unit this season and his skill position players, from running back Christian McCaffrey to a pair of thousand-yard receivers, are enviable. The stage is set for Darnold and Carolina to make a statement at New York’s expense.

Arizona Cardinals at Tennessee Titans (-3)

Sunday, Sep. 12 – 1 p.m. ET
After missing the postseason last year, Kyler Murray and the Cardinals need to start the season strong. Even if the Titans are the favorites here, the Cardinals could light up Tennessee’s defense.
This could quickly turn into a shootout as evidenced by the 52 points set on the totals, the second-highest over/under this week. Ryan Tannehill has All-Pro wideout Julio Jones to throw to but the team lost a handful of key players. As far as suspect favorites are concerned, pencil Tennessee in on the list.

Philadelphia Eagles at Atlanta Falcons (-3)

Sunday, Sep. 12 – 1 p.m. ET
From one potential upset to another: the Eagles could emerge as the superior bird here. Philadelphia has the better defense, at least upfront. Jalen Hurts, as enigmatic as he is, could be too difficult to stop for the helpless Falcons’ defense.
Atlanta is slated with one of the worst defenses in the NFL this season. But their offense should be fantastic as Matt Ryan could put up his best stats since his MVP season. However, that will hardly translate to wins when the Falcons give up more points. The Falcons only covered one of five home games as chalk so buyer beware.

Cleveland Browns at Kansas City Chiefs (-6)

Sunday, Sep. 12 – 4:25 p.m. ET
This matchup right here could be Week 1’s best game. Both Browns and Chiefs are legitimate Super Bowl contenders and this is a rematch of last year’s Divisional Round, which saw Cleveland put up a valiant effort.
As prolific as the Chiefs have been, they have been a terrible team on the spread. The Chiefs are 4-5 ATS at home but only 8-11 for the whole of 2020. Cleveland, on the other hand, is 4-2 as a road underdog. They covered against KC in their previous meeting and look to do more than just cover the spread against the Chiefs. This is their shot.

Miami Dolphins at New England Patriots (-3)

Sunday, Sep. 12 – 4:25 p.m. ET
The Dolphins and Patriots make up the only other divisional game for Week 1. These rivals have alternated beating each other for the last eight games. Mac Jones will take the reins at quarterback for New England while Tua Tagovailoa looks to do better in his sophomore season as a Dolphin.
There is considerable hype for the Patriots entering the season. They went on an uncharacteristic spending spree and appear much improved than last season. However, the Dolphins did finish 10-6 last year and Brian Flores may just be able to match wits against the GOAT himself, Bill Belichick.

Denver Broncos (-3) at New York Giants

Sunday, Sep. 12 – 4:25 p.m. ET
Few AFC teams have been as divisive as the Broncos: a team many pundits have finishing as high as playoff lock to as low as being the third-worst in the conference. It all depends on how well Vic Fangio can coach. He’s on the hottest of hot seats entering the season as an early slip from Denver could mean his dismissal.
The Broncos are stacked at key positions. The same can’t be said for the Giants. They have one of the worst offensive lines in the league and Daniel Jones is a mediocre quarterback at best. But they do have a solid defense and are 9-5 ATS as an underdog.

Green Bay Packers (-4) at New Orleans Saints

Sunday, Sep. 12 – 4:25 p.m. ET
The Aaron Rodgers drama is not entirely over in Green Bay. Still, the reigning MVP is back and should at least get back to putting up Madden-like numbers. The Saints will prove to be a stiff test but this team also lost plenty of key players on defense outside of Drew Brees retiring at quarterback.
Jameis Winston has yet to lead a team to the postseason as the star player. Sean Payton has helped make the likes of Bridgewater look like an All-Pro player. If Payton can unlock Winston’s potential, the Saints may just be a winning team again.

Chicago Bears at Los Angeles Rams (-9)

Sunday, Sep. 12 – 8:20 p.m. ET
The betting lines are shifting toward the Rams here. Los Angeles will debut Matthew Stafford at quarterback, who many see as the missing link for the team’s Super Bowl hopes. The Bears are no pushovers.
Chicago still has one of the most fearsome front-seven even if its secondary leaves plenty to be desired. Unfortunately, the Rams also have a stiff O-line that could neutralize the pressure Chicago generates. This is high time for Stafford to carve up the Bears as the Rams roll to a beatdown here.

Baltimore Ravens (-4½) at Las Vegas Raiders

Monday, Sep. 13 – 8:15 p.m. ET
The final game of the week features the traveling Ravens as slight favorites against Vegas. Baltimore went 4-3 ATS as a road favorite last season while Las Vegas went 3-3 ATS as a home underdog. But the Raiders have downgraded in a key spot this year: the offensive line.
The lack of protection upfront will only impede QB Derek Carr and the running game, especially against a top-five NFL defense in Baltimore. The Ravens suffered crushing losses Thursday at practice with RB Gus Edwards and DB Marcus Peter suffering what look like season-ending knee injuries.

NFL Week 1 Free Picks

After an in-depth analysis of the NFL Week 1 Betting Lines alongside the latest NFL Week 1 News, our panel of experts share their betting predictions for all 16 NFL Week 1 matchups. Here’s the rundown.


NFL Week 1 News

Our news page has all the NFL Week 1 content you could want. That’s right, you will be able to find the latest team, player and NFL News, stats, injury & weather reports, highlights and betting trends for all 32 teams right before you head to the NFL Week 1 Odds to place your ticket!

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