NFL Week 16 Game Previews, Odds, Picks & Predictions

Aaron Rodgers is keeping his word. The Green Bay Packers became the first team to clinch a Playoff spot. They shouldn’t have too much trouble winning their remaining three games and clinch the No. 1 seed in the NFC.

The Kansas City Chiefs are the new No. 1 in the AFC, but all seven Playoff berths are still available.

On the other hand, five teams have already been eliminated. The list includes the Jacksonville Jaguars, that will pick first, again, in the 2022 NFL Draft.

We already have the Week 16 odds fully loaded. Every game is crucial now, so be sure to check ‘em and pick your favorites!

NFL Week 16 Preview

After having two games rescheduled in Week 15 due to COVID-19, the NFL is expected to return to normal. That means a double-header on Saturday and no games on Tuesday.

The San Francisco 49ers and the Tennessee Titans will kick things off on Thursday Night. Both are in the hunt, so you can expect fireworks. Sunday will be full of divisional matchups, including Buffalo Bills vs New England Patriots. The AFC East top spot will be on the line.

Monday Night offers a matchup between two teams on the bubble, Miami Dolphins and New Orleans Saints. What else can you ask for!?

The NFL Week 16 odds are ready and waiting as we look through each game.

NFL Games of the Week


  • San Francisco 49ers (-3½)

    VS

    Tennessee Titans

    Thursday, December 23rd

    The San Francisco 49ers (8-6) won four of their last five games. Last week, they did it without Elijah Mitchell, who didn’t play due to injury. The rookie running back is expected to be back, making the Niners an even more dangerous team.

    Since coming off the injured reserve, tight end George Kittle has done a great job. He finished with 90+ yards in each of their last three games. Jeffrey Wilson, who replaced Mitchell in Week 15, did a great job as well.

    San Francisco is 1-7-1 against the spread in its last nine games against Tennessee.

    The Titans (9-5) keep leading the way in the AFC South, but the Indianapolis Colts are getting close. That’s why Tennessee can’t afford to lose against San Francisco.

    Last week, they fought bravely against the Pittsburgh Steelers despite not having AJ Brown due to injury. Julio Jones played but finished with no receptions. Derrick Henry remains sidelined, but D’Onta Foreman ran for more than 100 yards in Week 15.

    The total has gone over in nine of Tennessee’s last 13 games played in December.

  • Cleveland Browns

    VS

    Green Bay Packers (-7½)

    Saturday, December 25th

    The Cleveland Browns (7-7), or should I say the Cleveland Hospital, suffered a heartbreaking loss in Week 15. They lost 16-14 to the Las Vegas Raiders despite playing without Baker Mayfield, Kareem Hunt, and Jarvis Landry.

    As if that wasn’t enough, Myles Garrett had to play with a groin injury. Defensive Player of the Year candidate already said that he’ll go out there until he can’t. The Browns wouldn’t have a chance against the Green Bay Packers without him.

    Cleveland is 7-1 straight up in its last eight games against an opponent from the NFC.

    Aaron Rodgers and the Packers (11-3) won a thriller against the Baltimore Ravens. The game could have gone to overtime, but Baltimore went for it. Rodgers had another fantastic game throwing for 268 yards and three touchdowns.

    Receiver Marquez Valdes-Scantling is finally meeting expectations. It seems like Randall Cobb’s absence helped him.

    The Packers are 6-0 ATS in their last six games at home.

  • Indianapolis Colts (Pk)

    VS

    Arizona Cardinals

    Saturday, December 25th

    Give Jonathan Taylor the MVP already. The second year RB is the main reason for the Indianapolis Colts (8-6) to still be in the race. He leads the league in rushing yards (1518) and touchdowns (17).

    Last week, against the New England Patriots, Taylor ran the ball 29 times. None of Indianapolis’ receivers finished with more than one reception. That’s crazy.

    The Colts are 8-3 ATS in their last 11 games.

    Can you imagine losing to the Detroit Lions? The Arizona Cardinals (10-4) can’t, because they already did. That’s right, they lost 30-12. Kyler Murray really missed DeAndre Hopkins, who’ll miss the rest of the regular season due to injury.

    That means it’s time for A.J. Green, Zach Ertz, and Christian Kirk to step up. Beating the Colts will be a first tough challenge, but it’s not impossible. Fortunately for them, RB Chase Edmonds is back. Edmonds and James Conner have the potential to be the best backfield duo in the league.

    Arizona is 5-0 ATS in its last five games against an opponent from the AFC South.

  • New York Giants

    VS

    Philadelphia Eagles (-10)

    Sunday, December 19th

    The New York Giants (4-10) decided to shut down Daniel Jones for the rest of the regular season. Veteran Mike Glennon has been replacing him, but I think it’s time for Jake Fromm to start. Glennon threw for 99 yards and three interceptions in Week 15.

    Sterling Shepard suffered a torn left Achilles, so he won’t be playing either. The Giants’ hope relies on Saquon Barkley, who at least has managed to stay healthy.

    New York is 0-7 SU in its last seven games when playing on the road against Philadelphia.

    The Eagles (7-7) are on the bubble, just waiting for the San Francisco 49ers or the Minnesota Vikings to lose. Jalen Hurts returned in Week 15 and led the way against Washington with three total touchdowns.

    Dallas Goedert finished the game with seven receptions for 135 yards. I guess the front office was right about trading Zach Ertz.

    The total has gone over in four of Philadelphia’s last five games when playing at home.

  • Los Angeles Rams (-3)

    VS

    Minnesota Vikings

    Sunday, December 19th

    Things in the NFC West are heating up! The Los Angeles Rams defeated the Seattle Seahawks and now own the same record than the Arizona Cardinals, 10-4.

    Cooper Kupp had another amazing performance with nine receptions for 136 yards and two touchdowns. If you ask me, he and Taylor should be the MVP candidates, no one else. Darrell Henderson is back and expected to regain his role as starting RB.

    The Rams are 5-2 in their last seven games on the road.

    The Minnesota Vikings (7-7) depend only on themselves to get into the postseason. They managed to defeat the Chicago Bears in Week 15 despite Adam Thielen not being able to play. Dalvin Cook ran the ball 28 times. Expect more of the same when they play host to the Rams.

    If Thielen isn’t cleared to play, K.J. Osborn and Tyler Conklin need to step up. Beating the Rams won’t be easy at all, Kirk Cousins needs all the help he can get.

    The total has gone over in 13 of Minnesota’s last 19 games against an opponent from the NFC.

  • Buffalo Bills (-2½)

    VS

    New England Patriots

    Sunday, December 19th

    Best divisional matchup scheduled for Sunday, no doubt about it! They met two weeks ago under a blizzard and the New England Patriots won 14-10. Mac Jones only threw three passes.

    We all expect weather conditions to be a lot better for the rematch. The AFC East top spot will be on the line, and we want to see both playing at their best.

    The Buffalo Bills (8-6) beat the Carolina Panthers in Week 15, while the Patriots (9-5) lost to the Indianapolis Colts. Regarding the Bills, Devin Singletary ran for 86 yards and one touchdown in 22 attempts. On the other hand, the Patriots really missed Damien Harris, who couldn’t play due to injury.

    Expect a nice battle between Dawson Knox and Hunter Henry, two of the best TE’s in the league. You can also expect a back-and-forth battle, enough to consider the total going over. Just like it happened in four of New England’s last five games at home.

  • Tampa Bay Buccaneers (-11½)

    VS

    Carolina Panthers

    Sunday, December 19th

    Believe it or not, Tom Brady and the Tampa Bay Buccaneers didn’t score a single point in Week 15. They lost 9-0 to the New Orleans Saints, but that’s not all. They also lost Leonard Fournette for the rest of the regular season. They’re expected to sign Le’Veon Bell, no, I’m not kidding.

    Chris Goodwin won’t be playing for the rest of the regular season either, while Mike Evans is questionable. Antonio Brown and Breshad Perriman are expected to return, otherwise they could suffer a lot when visiting the Carolina Panthers.

    The Buccaneers are 12-3 SU in their last 15 games on the road.

    Carolina still has a shot to make the postseason, but Cam Newton isn’t helping. He’s not a bad quarterback, but he’s too inconsistent. Plus, Christian McCaffrey remains sidelined and Chuba Hubbard isn’t helping either. Ameer Abdullah is trying, but he needs more time to adapt.

    These two will meet twice over the last three weeks of the regular season.

    The Panthers are 3-10 in their last 13 games against an opponent from the NFC South.

  • VS

    New York Jets

    Sunday, December 19th

    Both are eliminated, so let’s move on. No, I’m kidding.

    The Jacksonville Jaguars (2-12) fired Urban Meyer prior to their Week 15 matchup with the Houston Texans but still lost. James Robinson regained the lead role on offense and finished with 75 yards and one touchdown.

    Trevor Lawrence didn’t throw a touchdown pass, but hey, he didn’t throw an interception either. Jacksonville is 4-1 ATS in its last five games against an opponent from the AFC East.

    The New York Jets (3-11) lost to the Miami Dolphins in Week 15. Rookie QB Zach Wilson threw for 170 yards, that’s it. That’s why a lot of fans are asking for Mike White to be under center. He’ll be back after missing some games due to injury and COVID-19.

    Michael Carter returned last week, but veteran Tevin Coleman proved he deserves to remain the starter. Both ran the ball eight times, Coleman finished with 50 yards, while Carter only 18.

    The total has gone over in four of the Jets’ last five games when playing at home against Jacksonville.

  • Detroit Lions

    VS

    Atlanta Falcons (-6)

    Sunday, December 19th

    The Detroit Lions (2-11-1) crushed the Arizona Cardinals in Week 15. Jared Goff looked like an elite QB after throwing for 216 yards and three touchdowns. Amon-Ra St. Brown is finally meeting expectations. He finished with eight receptions for 90 yards and one touchdown.

    The best news for them is that Craig Reynolds ran for 112 yards. He might be the answer they were looking for regarding the backfield.

    Detroit is 0-7-1 SU in its last eight games on the road.

    I’m not sure the Atlanta Falcons (6-8) deserve to be the favorites against the Lions. The offense is a disaster, but not everything is bad news. Receiver Russell Gage is finally meeting up expectations. He finished with eight receptions for 91 yards and one touchdown in Week 15.

    Unfortunately for them, TE Kyle Pitts isn’t meeting expectations.

    The total has gone over in seven of Atlanta’s last nine games when playing at home against Detroit.

  • Los Angeles Chargers (-9½)

    VS

    Houston Texans

    Sunday, December 19th

    Justin Herbert and the Los Angeles Chargers suffered a heartbreaking loss to the Kansas City Chiefs in Week 15. The divisional title race isn’t over, but the Chiefs are in control now.

    Los Angeles has one of the best receiver corps in the league with Keenan Allen, Mike Williams, and Jared Cook. The thing is that they need to be more consistent. Austin Ekeler won’t be playing, so Justin Jackson will be leading the backfield. Joey Bosa is also out, but they still deserve to be favorites against Houston.

    The Chargers are 6-2 ATS in their last eight games on the road.

    The Texans (3-11) are eliminated. The remaining games will be like a camp to see who’s in and who’s out for next season. Davis Mills wants to prove he deserves to be the starting QB. I think he deserves it, but I’m not the head coach.

    Brandin Cooks remains an elite WR. In Week 15 he caught seven passes for 102 yards and two touchdowns. Bring him some help!

    Houston is 2-6 ATS in its last eight games played in December.

  • Baltimore Ravens

    VS

    Cincinnati Bengals (-2½)

    Sunday, December 19th

    The Baltimore Ravens (8-6) have become specialists in losing close matches. Last week, they went for it in the last play of the game and lost 31-30 to Green Bay. They still are in the divisional title race, but Cincinnati is in command now.

    Lamar Jackson didn’t play against the Packers, but Tyler Huntley did a great job. He threw for 215 yards and two touchdowns. He also ran for 73 yards and two more touchdowns. Mark Andrews finished with 10 receptions for 136 yards and two touchdowns. He’s not missing Jackson.

    The Ravens are 5-1 SU in their last six games against the Bengals.

    Cincinnati defeated Denver in Week 15. Joe Burrow threw for 157 yards and one touchdown. Burrow and Tyler Boyd are becoming one of the best duos in the league. And don’t forget Tee Higgins and Ja’Marr Chase are on the team as well.

    The Bengals are 10-1 ATS in their last 11 games played in Week 16.

  • Chicago Bears

    VS

    Seattle Seahawks (-7)

    Sunday, December 19th

    The Chicago Bears (4-10) are also officially eliminated. It has been a rocky first year for QB Justin Fields, but I think he already proved he can be the answer. If healthy, David Montgomery can become one of the best runners in the league. That means that next year should be a lot better for them.

    Chicago is 1-5 SU in their last six games when playing on the road against Seattle.

    The Seahawks (5-9) are still in the hunt, but their margin for error got chop after losing to the Rams in Week 15. Russell Wilson has been improving, but he needs to play a lot better for them to keep hope alive.

    Rashaad Penny was supposed to have a great game, but he was outplayed by Deejay Dallas. They’ve really missed Chris Carson.

    The Seahawks are 1-6 SU in their last seven games against an opponent from the NFC.

  • Pittsburgh Steelers

    VS

    Kansas City Chiefs (-10)

    Sunday, December 19th

    Believe it or not, the Pittsburgh Steelers (7-6-1) still have a chance. They beat the Titans in Week 15 despite thanks to a rushing touchdown from Ben Roethlisberger. It’s not a typo, Big Ben scored a rushing touchdown.

    Diontae Johnson and Najee Harris have had a great season, but that’s it. The Steelers aren’t title contenders.

    Pittsburgh is 3-6 ATS in its last nine games against an opponent from the AFC West.

    The Kansas City Chiefs (10-4) are now in control of the AFC. They depend only on themselves to clinch to No. 1 seed.

    They could be in trouble, though. Travis Kelce and Tyreek Hill tested positive for COVID-19. Without them, the Chiefs aren’t so scary, but still deserve to be favorites against the Steelers.

    The total has gone under in four of Kansas City’s last five games when playing at home against Pittsburgh.

  • Denver Broncos

    VS

    Las Vegas Raiders (-1)

    Sunday, December 19th

    Both are still in the hunt, but Denver Broncos vs Las Vegas Raiders isn’t a particularly interesting game.

    The Broncos (7-7) will be without Teddy Bridgewater and Drew Lock isn’t a guarantee. Melvin Gordon and Javonte Williams should be enough to carry the load, but they’re dealing with some injuries.

    Denver is 0-5 ATS in their last five games when playing on the road against Las Vegas.

    The Raiders (7-7) beat the Browns in Week 15 despite not having TE Darren Waller. He remains sidelined due to injury. Zay Jones and Foster Moreau have been doing a great job, but Waller has no comparison.

    Josh Jacobs should also be enough to carry the load, but he’s also dealing with a minor injury.

    The total has gone over in 11 of Las Vegas’ last 15 games against an opponent from the AFC.

  • Washington Football Team

    VS

    Dallas Cowboys (-10½)

    Sunday, December 19th

    The Dallas Cowboys (10-4) are in complete control of the NFC East. However, their main goal is to clinch the No. 1 seed.

    Their offensive unit is one of the best in the league thanks to Dak Prescott, Ezekiel Elliott, CeeDee Lamb, and Amari Cooper. Their defense has been pretty good as well, allowing 20 points or less in each of their last three games.

    Dallas is 6-0 SU in their last six games played in December.

    Washington (6-8) is still in the hunt, but they lost their last two games. The bad news is that we’re talking about divisional games. That’s why they fell to third place in the NFC East.

    Antonio Gibson has had a great season, but it hasn’t been enough for them to be able to keep up. They’ve really missed Chase Young.

    The total has gone over in Washington’s last six games against Dallas.

  • Miami Dolphins

    VS

    New Orleans Saints (-3)

    Monday, December 20th

    The Miami Dolphins (7-7) are on a roll and Tua Tagovailoa has a lot to do with that. They won their last six straight games and scored 30+ points in two of their last three matches.

    Last week, they defeated the Jets despite not having Jaylen Waddle available due to injury. Fortunately for them, Davante Parker had a great game.

    Miami is 1-4 SU in its last five games on the road.

    The New Orleans Saints (7-7) are highly motivated after beating the Tampa Bay Buccaneers 9-0. When healthy, Taysom Hill is one of the best dual-threat quarterbacks in the league. Alvin Kamara hasn’t been the same, but he can explode any given Sunday.

    Not having Michael Thomas available has been an issue, but Marquez Callaway is starting to meet expectations. He had six receptions for 112 yards in Week 15. He’s expected to have a huge game when facing the Dolphins.

    The Saints are 4-2 SU in their last six games when playing at home against Miami.

NFL Week 16 News

Our NFL news page has all the NFL Week 16 content you could want. That’s right, you will be able to find the latest team, player and NFL News, stats, NFL injuries & weather reports, highlights and betting trends for all 32 teams right before you head to the NFL Week 16 Odds to place your ticket!

NFL Week 16 Picks

After an in-depth analysis of the Football Betting Lines for Week 12 alongside the latest NFL Week 16 News, our panel of experts share their NFL picks for all 16 NFL Week 16 matchups. Here’s the rundown.

NFL Week 16 Preview & Early NFL Picks | NFL Odds, NFL Saturday Predictions & TNF Picks

Net6Premium