Football fans around the world can gear up for Week 2 of the NFL regular season starting on Thursday night. For all the betting enthusiasts out there, we already have the Week 2 odds fully loaded. Be sure to check ‘em and pick your favorites!
NFL Week 2 Preview
Bettors can enjoy 17 quality NFL games this week, starting with the New York Giants vs Washington Football Team on Thursday. The NFL Week 2 odds are ready and waiting as we look through each game.
NFL Games of the Week
New York Giants
Washington Football Team (-3½)September 16, 8:20 p.m. ET
A close game is expected as both teams search for their first win. Washington quarterback Taylor Heinicke was solid off the bench in his season debut against the Los Angeles Chargers, which ended in a 20-16 loss. He wasn’t asked to do much, with only 15 passes attempted, but he will be in the spotlight after replacing an injured Ryan Fitzpatrick..
All eyes will also be on New York’s Daniel Jones and how he improves with a game under his belt. He went 22 of 37 in an opening loss to the Denver Broncos, but it was a disappointing effort overall. He would dearly love running back Saquon Barkley healthy, but his availability is undetermined.
Giants vs Washington betting markets have Washington as 3½-point favorites, which looks right. It should be a tight contest to open Week 2.
New Orleans Saints (-3½)
Carolina PanthersSeptember 19, 1 p.m ET
Despite the New Orleans Saints having some Covid protocol problems this week, most of the money has come for the impressive Week 1 winners. With Jameis Winston playing quarterback, the Saints were dynamic on offense in the 38-3 win over the Green Bay Packers.
It bodes well against the Panthers, who scored a 19-14 win over the New York Jets, but it wasn’t overly convincing. Former Jets quarterback Sam Darnold did well to handle the pressure of playing for a new team and running back Christian McCaffrery was solid. However, keeping up with the electric offense of the Saints won’t be easy.
The line opened at -3, but money has shifted the line and we expect that to continue to drift on game day.
Cleveland Browns (-13)September 19, 1 p.m ET
Cleveland looked to be in control vs the Kansas City Chiefs last week, but it was unable to hold on for the win. It was a disappointing result for the Browns, but we think they will have the memory of a goldfish against the Houston Texans.
The Browns are a team that can pile on the points quickly, as the NFL betting lines suggest. The Texans crushed Jacksonville 37-21 but could struggle to keep up with the Browns on offense, especially if Baker Mayfield is on his game.
Value is with the Browns, who are no strangers to covering large betting spreads.
Chicago Bears (-2½)September 19, 1 p.m ET
Not many expected the Chicago Bears to open as favorites against the Bengals, especially after Cincinnati beat Minnesota 27-24 in the opener.
We have seen money come for the Bengals throughout the week, which isn’t surprising. Quarterback Joe Burrow is a popular player for the Bengals, so he will always attract money no matter what level of opposition they are playing.
Chicago is in a tricky quarterback situation. Andy Dalton wasn’t bad in Week 1, but with rookie Justin Fields waiting in the wings, it’s only a matter of time before they get him out there. We don’t think Fields will play against the Bengals, which is why there has been money for the Bengals at the +2½ line.
Las Vegas Raiders
Pittsburgh Steelers (-5½)September 19, 1 p.m ET
We all love a Raiders vs Steelers game, which pits two hard-nosed teams against each other.
Pittsburgh relied on its defense to beat Buffalo 23-16 last week. It was a classic Steelers performance and it holds them in good stead against Oakland.
Bettors never know what to expect from the Raiders. We thought they would beat Baltimore, but we didn’t expect the overtime thriller. It was a crazy game, and if the Raiders bring the same energy in Week 2, we could witness a classic.
Pittsburgh should have the edge on the Raiders, who struggled to contain Lamar Jackson in the pocket. It has a superior defense and it should be able to put pressure on Derek Carr, who isn’t the most consistent quarterback in the league.
Buffalo Bills (-3½)
Miami DolphinsSeptember 19, 1 p.m ET
It’s only a matter of time before Josh Allen gets the Buffalo Bills doing wondrous things. It didn’t happen against the Steelers, but the Dolphins could be left in open water on Sunday.
We like what the Dolphins did against the Patriots in their 17-16 Week 1 win, but they were playing against a rookie quarterback in Mac Jones. It’s a different situation against Allen, who was one of the best quarterbacks in the NFL last season.
Bills vs Dolphins lines have the Bills as only -3½ favorites. We expected the line to be around 6½, so bookmakers are respecting Miami and it would be foolish to rule them out.
Los Angeles Rams (-3½)
Indianapolis ColtsSeptember 19, 1 p.m ET
We’re not sure what to expect from the Colts this season and that’s reflected in betting markets. Most of the money has come for the Rams, and the current betting line could move before game day. The Rams have a renewed confidence with Matthew Stafford at quarterback and we already know their defense is ferocious.
The Colts lost 28-16 at home to Seattle and will need to play smart football to keep this game close. The Rams vs Colts betting markets are interesting, and it’s another game we thought the favorite would be shorter with bookmakers. However, we expect the Rams to take care of business and improve to 2-0.
We wouldn’t be surprised to see money come for the Rams. They could emerge as a public betting team, so the lines should start to inflate.
San Francisco 49ers (-3)
Philadelphia EaglesSeptember 19, 1 p.m ET
Bettors don’t quite know what to make of the 49ers’ 41-33 win against the Detroit Lions last week. They looked good for the first three quarters, but allowed the Lions to score 16 points in the fourth quarter.
We would have liked to have seen the 49ers finish the job in style, especially with the Eagles on deck. Philadelphia is another team with a renewed sense of direction due to a quarterback change. Not much was working with Carson Wentz, and Jalen Hurts made a terrific start to his season in a 32-6 rout of Atlanta.
Money has come for the 49ers after the spread opened at -110 and it’s now -120, but we’re respectfully disagreeing and expecting the Eagles to provide a stiff test.
Denver Broncos (-6)
Jacksonville JaguarsSeptember 19, 1 p.m ET
The Broncos and Jaguars match up quite well, so we’re expecting a closely fought contest. Former Clemson star Trevor Lawrence made a poor start to his NFL career in a 37-21 loss to Houston, but we’re prepared to give him time. However, time goes by pretty quickly in this sport and his team could be 0-2 in the blink of an eye.
Denver was solid in a 27-13 victory at the New York Giants and it’s a team that could make some waves in its division. The -6 betting spread is a sizable margin for a Jaguars home game, but bettors have lost confidence in this team after only one week. It’s surprising given the hype around Lawrence, so we wouldn’t be so quick to drop them just yet.
New England Patriots
New York Jets (-6)September 19, 1 p.m ET
Despite losing their opening game 17-16 to Miami, we saw enough from the New England Patriots to have confidence in Week 2. Rookie Mac Jones was a revelation and he looks good enough to take the Patriots to a possible playoff spot. Jones vs Zach Wilson is a mouth-watering matchup this week, so we’re looking forward to the rookie quarterbacks dueling at MetLife Stadium.
The Jets can’t seem to shake their losing ways, which often have a trickle-down effect. They might be an improved team in 2021, but until they start winning consistently, bettors won’t have much confidence. That being said, the +6 has been best-backed in early NFL markets.
It’s not a surprise given how much money typically comes in for the Patriots. Tom Brady might be gone, but they will always be favored with bettors.
Arizona Cardinals (-3½)September 19, 4:05 p.m. ET
One of the more impressive teams in the opening week were the Arizona Cardinals. Kyler Murray had the ball on a string in the 38-13 win at Tennessee and his form is likely to continue against the Minnesota Vikings. We’re not talking down the Vikings, as they’re a tough team, but Murray might have gone to another level.
Playing on a fast track inside a dome almost certainly helps the Cardinals, among the reasons we thought we would see more betting action on the home team.
The -3½ has remained steady throughout the week, so there is two-way action for the Vikings vs Cardinals.
Tampa Bay Buccaneers (-12½)September 19, 4:05 p.m. ET
Betting against Tom Brady is often a mistake, as Dallas Cowboys fans found out last week. Brady orchestrated another late comeback to see the defending Super Bowl champs off to a successful start. Betting markets expect the Buccaneers to remain perfect against the Falcons, who couldn’t have been more disappointing in a 32-6 home loss to Philadelphia.
There was a lot of early money on the Falcons against the Eagles last week, but the Falcons turned up with no passion. Matt Ryan didn’t have an answer, which doesn’t bode well against the Buccaneers on Sunday.
Tampa Bay opened at -13½, so there has been money for the Falcons. However, we wouldn’t be surprised to see this line move back to its original figure come game time.
Seattle Seahawks (-5½)September 19, 4:25 p.m. ET
The Tennessee Titans vs Seattle Seahawks is always a good match up. Seattle was solid in its Week 1 victory, which included Russell Wilson going 18 of 23 for 254 yards and four touchdowns in a 28-16 win at Indianapolis. He was getting time in the pocket, which often results in wins for Seattle.
The Titans were manhandled 38-13 by the Arizona Cardinals, and it’s not the confidence boost this team needed. There are already concerns about their season and starting with a thrashing at home doesn’t help. However, the Titans vs Seahawks opening line of -6 has moved to -5½. It might seem insignificant, but it suggests money is coming for the away team.
Los Angeles Chargers (-3)September 19, 4:25 p.m. ET
One of the more surprising lines of the week is the Cowboys vs Chargers. Bookmakers have the Chargers as -3 favorites, but we thought the Cowboys did enough against Tampa Bay in their 31-29 road loss to suggest they would open as the bookmakers’ elect.
Dak Prescott is already in MVP talks after his fine performance, but there is also confidence with Chargers quarterback Justin Herbert, who went 31 of 47 for 337 yards. It wasn’t nearly as impressive as Prescott’s 403 yards with three touchdowns, but the Chargers got the better of a tough Washington outfit.
The line hasn’t moved since markets opened and there is value with the Cowboys at a generous moneyline price.
Kansas City Chiefs (-3½)
Baltimore RavensSeptember 19, 8:20 p.m. ET
The marquee game of the week involves the offensive-minded Chiefs and Ravens, who are no strangers to scoring plenty of points. The Chiefs came from behind to beat the Cleveland Browns 33-29.
Baltimore blew a 14-point lead in a 33-27 overtime loss to the Las Vegas Raiders, which could scar them for weeks. Lamar Jackson was excellent at escaping pressure in the pocket, but he was widely inaccurate with his passing, which has been a concern from the outset. Kansas City could pounce on that and improve its record to 2-0.
The Chiefs vs Ravens line is an interesting one. The Chiefs are the better team, but they’re favored by only 3½ points. We believe they’re capable of winning by double digits, and if bettors agree, the line could move significantly on game day.
Green Bay Packers (-11)September 20, 8:15 p.m. ET
Redemption is on the minds of the Green Bay Packers players, who looked dejected following a horrible 38-3 loss to the New Orleans Saints. The usually stoic Aaron Rodgers looked like a defeated man, which isn’t a good sign against the Lions on Monday.
The Lions showed courage when coming back to score 16 fourth-quarter points against the 49ers. The game was out of reach, but some teams would have thrown in the towel and allowed the romp to be completed. It showed that the Lions might not be as talented as teams like the 49ers or the Packers, but they want to win.
We didn’t see that with the Packers, so the -11 line is tough to take. It opened at 10½, so bettors are expecting the Packers to perform better than last week, but we need to see it to believe it.
NFL Week 2 Picks
After an in-depth analysis of the NFL Week 2 betting lines alongside the latest NFL Week 2 news, our panel of experts share their betting predictions for all 16 NFL Week 2 matchups. Here’s the rundown.