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What Are Betting Lines for Week 1 of the 2021 NFL season?

It may be May 12 but the NFL never ceases to amaze in its ability to grab headlines.

The league is revealing its 2021 schedule on Wednesday and let its partner networks get ahead of the game by showcasing their Week 1 broadcasts.

Tom Brady
JONATHAN DANIEL/ GETTY IMAGES

BetUS, of course, is in step with America’s Game and has all the early betting lines on the first week of the first 17-game season.

Who Plays Who?

The season kicks off, per usual, with the Super Bowl champion Tampa Bay Buccaneers playing host to a Thursday night game. And nothing is left to chance by the NFL when it comes to the ratings game because Tom Brady Co. will face the Dallas Cowboys.

That also should mark the return of Dak Prescott as the Cowboys’ quarterback after his 2020 season was short-circuited by injury.

Other big matchups include the Pittsburgh Steelers at the Buffalo Bills, the Cleveland Browns at the Kansas City Chiefs, and the Seattle Seahawks at the Indianapolis Colts.

Who are the Favorites?

NFL Week 1

Thu, Sep 09, 2021 EST

ROT
TEAM
POINT SPREAD
MONEYLINE
TOTAL
TEAM TOTAL
 8:20p
451
+6½ -110
452
-6½ -110

Sun, Sep 12, 2021 EST

 

ROT
TEAM
POINT SPREAD
MONEYLINE
TOTAL
TEAM TOTAL
 1:00p
453
+6½ -110
454
-6½ -110
 1:00p
455
+4 -110
456
-4 -110
 1:00p
457
-2 -110
458
+2 -110
 1:00p
459
+2½ -110
460
-2½ -110
 1:00p
 1:00p
463
+3½ -110
464
-3½ -110
 1:00p
465
+2½ -110
466
-2½ -110
 1:00p
467
-3 Ev
468
+3 -120
 1:00p
469
-7½ -115
470
+7½ -105
 4:25p
471
+6 -110
472
-6 -110
 4:25p
473
+2 -110
474
-2 -110
 4:25p
475
pk -110
476
pk -110
 8:20p
479
+7 -110
480
-7 -110

Mon, Sep 13, 2021 EST

 

ROT
TEAM
POINT SPREAD
MONEYLINE
TOTAL
TEAM TOTAL
 8:15p
481
-5 -110
482
+5 -110

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