What Are Betting Lines for Week 1 of the 2021 NFL season?
It may be May 12 but the NFL never ceases to amaze in its ability to grab headlines.
The league is revealing its 2021 schedule on Wednesday and let its partner networks get ahead of the game by showcasing their Week 1 broadcasts.

BetUS, of course, is in step with America’s Game and has all the early betting lines on the first week of the first 17-game season.
Who Plays Who?
The season kicks off, per usual, with the Super Bowl champion Tampa Bay Buccaneers playing host to a Thursday night game. And nothing is left to chance by the NFL when it comes to the ratings game because Tom Brady Co. will face the Dallas Cowboys.
That also should mark the return of Dak Prescott as the Cowboys’ quarterback after his 2020 season was short-circuited by injury.
Other big matchups include the Pittsburgh Steelers at the Buffalo Bills, the Cleveland Browns at the Kansas City Chiefs, and the Seattle Seahawks at the Indianapolis Colts.
Heres how well be kicking off the NFLs biggest season ever on FOX 🙌
The full 2021 NFL schedule will be revealed TONIGHT at 8pm ET / 5pm PT on NFL Network and FS1! pic.twitter.com/v0XRMM2f05
FOX Sports: NFL (@NFLonFOX) May 12, 2021
The countdown to Week 1 is on.
Tonight, the full season schedule will be released at 8 pm ET on the NFL Network. pic.twitter.com/LVvzjMtTVI
NFLonCBS (@NFLonCBS) May 12, 2021
Are you ready for Week 1?!
Week 1 tickets are now available! https://t.co/mjp9JMwBpM
📺: #NFLScheduleRelease — TONIGHT (8pm ET) on @nflnetwork pic.twitter.com/t9OxqLKseW
NFL (@NFL) May 12, 2021
Who are the Favorites?
NFL Week 1
Thu, Sep 09, 2021 EST
Sun, Sep 12, 2021 EST
Mon, Sep 13, 2021 EST