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Atlanta Falcons vs San Francisco 49ers: Betting Guide

The San Francisco 49ers currently lead the second tier of playoff contenders in the NFC. While the Arizona Cardinals, Green Bay Packers, Tampa Bay Buccaneers, Dallas Cowboys and Los Angeles Rams have some breathing room in the NFC playoff race, the 49ers (7-6) lead five other teams by just a game. Atlanta is in that group so San Francisco’s matchup against the visiting Falcons has significant postseason implications.

The 49ers have been one of the best road teams in the NFC, going 5-2, but winning at home has proven to be more of a challenge as San Francisco has lost eight of its last 10 home games, although the two wins at home have come in the last two games.

Falcons vs 49ers

Atlanta has followed a similar script with a 5-2 road record. The Falcons have only one win at home and that came against the three-win New York Jets, so this could be a challenging assignment taking on San Francisco.

San Francisco (+3300) has the sixth-best odds among NFC teams to win the Super Bowl according to the NFL odds and lines.

  • Game: Atlanta Falcons (6-7) vs San Francisco 49ers (7-6)
  • Location: Levi’s Stadium
  • Day/Time: Sunday, 4:05 p.m. ET
  • Television: CBS

Falcons vs 49ers NFL Betting Lines

Team Point Spread Moneyline Over/Under
Atlanta Falcons +10 (-125) +320 46½ (-110o)
San Francisco 49ers -10 (+105) -400 46½ (-110u)


The San Francisco 49ers were listed by the NFL picks against the spread as 10-point favorites against the visiting Atlanta Falcons when the teams last met in 2019.

A Robbie Gould field goal and Kyle Juszczyk touchdown catch gave San Francisco a nine-point lead in the fourth quarter. Another field goal by Gould made it a 22-17 lead for the 49ers with 1:48 left to play. Matt Ryan connected with Julio Jones for a winning touchdown with two seconds left and Olamide Zaccheaus fell on a fumble in the end zone on the final play of the game as Atlanta won 29-22.

It was the ultimate bad beat as that final touchdown put the game over the 49½-point total. It was the fourth time in the last five Atlanta-San Francisco showdowns that the game went over the total. It was the third time in the last four meetings that Atlanta covered

Atlanta Falcons

Next game: vs. Detroit Lions

Last Game

The visiting Atlanta Falcons were listed by the Las Vegas odds as 2½-point underdogs against the Carolina Panthers

A defensive touchdown midway through the second quarter gave Atlanta the lead for good. The lead grew to 15 points 43 seconds into the fourth quarter on a Hayden Hurst touchdown catch and a field goal. Carolina made it a one-score game on a Robby Anderson TD catch with 3:11 left but the Panthers wouldn’t get the ball back.

Younghoe Koo’s 48-yard field goal with 6:10 remaining pushed the game over the 42½-point total.

Injury Report

Defensive lineman Jonathan Bullard (knee), safety Richie Grant (ankle), and linebackers Dante Fowler (calf) and Adetokunbo Ogundeji (ankle) are questionable. Linebacker Daren Bates (groin) is out. Emmanuel Ellerbee (knee) is on the reserve/COVID-10 list. Safety Erik Harris (pectoral) is out for the season. Receiver Calvin Ridley is on the injured reserve/non-football injury list.

San Francisco 49ers

Next game: at Tennessee Titans

Last Game

The visiting San Francisco 49ers were one-point favorites against the Cincinnati Bengals. San Francisco took a 14-point lead midway through the third quarter before Cincinnati rallied to tie the game on a pair of Ja’Marr Chase touchdown catches in the fourth quarter.

Cincinnati got the ball first in overtime but the Bengals settled for a field goal. San Francisco won the game on a 12-yard touchdown pass from Jimmy Garoppolo to Brandon Aiyuk for the 26-23 win as the game landed on the 49-point total.

Injury Report

Running back Elijah Mitchell (concussion), linebackers Azeez Al-Shaair (elbow), Fred Warner (ankle), and Dre Greenlaw (abdominal), and cornerbacks Dontae Johnson (personal) and Ambry Thomas (head) are questionable. Running back Trenton Cannon (concussion), defensive lineman Dee Ford (concussion), and cornerback Emmanuel Moseley (ankle) are out. Running back Trey Sermon (ankle) and offensive lineman Mike McGlinchey (quadricep) are on injured reserve.

Falcons vs 49ers Final Betting Analysis

Despite a variety of injuries at the running back position, San Francisco is in the top 10 in the NFL in rushing offense.

Both teams have negative turnover margins and that has played a role in their mediocrity.

San Francisco’s Deebo Samuel has been one the most productive receivers in the NFL. He has three catches of more than 75 yards and is seventh in the league with 1,028 receiving yards. Of the 48 players with at least 50 catches, none average more yards per reception than Samuels’ 18 yards per catch. He also has five rushing TDs in his last four games.

With Julio Jones now playing for the Tennessee Titans and Calvin Ridley opting out for much of the season, new go-to offensive options have emerged for the Falcons. Rookie tight end Kyle Pitts leads the team with 54 catches and 770 receiving yards. Cordarrelle Patterson has scored five touchdowns both rushing and receiving.

Atlanta linebacker Foye Oluokun is second in the NFL with 142 tackles while San Francisco’s Nick Bosa is tied for third with 14 sacks.

The total went under in four of Atlanta’s last five games.

Those who bet online would be interested to know that the Falcons have covered five of their last six games on the road.

San Francisco is 4-1 against the spread in its last five games.

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